4-Bromo-2-methylpyridine

Product Name: 4-Bromo-2-methylpyridine
CAS No.: 22282-99-1
Chemical Name: 4-Bromo-2-methylpyridine
Synonyms: -4-bromopyridine;4-BROMO-2-PICOLINE;CHEMBRDG-BB 4014101;4-BROMO-2-PICOLINE HCL;4-BROMO-METHYL-PYRIDINE;4-Bromo-2-methylpyridie;4-BROMO-2-METHYLPYRIDINE;2-METHYL-4-BROMOPYRIDINE;4-bormo-2-methylpyridine;4-BroMo-2-Methylpyridine0
CBNumber: CB9425671
Molecular Formula: C6H6BrN
Formula Weight: 172.02
MOL File: 22282-99-1.mol

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4-Bromo-2-methylpyridine Property

Melting point:: 26-27°
Boiling point:: 76 °C / 14mmHg
Density: 1.450 g/mL at 25 °C
refractive index: n 20/D 1.556
Flash point:: 174 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Dichloromethane
form: Pale Yellow Liquid
pka: 4.38±0.10(Predicted)
color: Colorless to Light yellow to Light orange
Water Solubility: Miscible with dichloromethane. Immiscible with water.
InChI: InChI=1S/C6H6BrN/c1-5-4-6(7)2-3-8-5/h2-4H,1H3
InChIKey: JFBMFWHEXBLFCR-UHFFFAOYSA-N
SMILES: C1(C)=NC=CC(Br)=C1
CAS DataBase Reference: 22282-99-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38-20/21/22
Safety Statements: 26-36/39-36
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 662739
Product name: 4-Bromo-2-methylpyridine
Purity: 96%
Packaging: 1g
Price: $48.22
Updated: 2025/07/31

Sigma-Aldrich

Product number: 662739
Product name: 4-Bromo-2-methylpyridine
Purity: 96%
Packaging: 250mg
Price: $54.7
Updated: 2023/06/20

TCI Chemical

Product number: B3279
Product name: 4-Bromo-2-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $36
Updated: 2025/07/31

TCI Chemical

Product number: B3279
Product name: 4-Bromo-2-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $108
Updated: 2025/07/31

TRC

Product number: B685560
Product name: 4-Bromo-2-picoline
Packaging: 2g
Price: $195
Updated: 2021/12/16

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4-Bromo-2-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

4-Bromo-2-methylpyridine is used as a starting material in the preparation of crown-ester-bipyridines and viologens through sodium or nickel reductive coupling, side chain oxidation and esterification. Further, it serves as an important raw material and intermediate in organic synthesis, pharmaceuticals, agrochemicals and in dyes.

Uses

4-Bromo-2-methylpyridine is a starting material used in a synthesis of crown-ester-bipyridines and viologens via sodium or nickel reductive coupling, side chain oxidation and esterification.

Uses

Used in the preparation of phenyloxadiazolyl pyridines as immunomodulating agents.

Synthesis

18437-58-6

22282-99-1

2-Methyl-4-aminopyridine (152) (10.1 g, 93.4 mmol) was used as a raw material, which was dissolved in 48% aqueous hydrobromic acid (165 mL) at -10°C and stirred to form a solution. An aqueous solution of sodium nitrite (7.04 g, 0.102 mol) pre-cooled to 0°C (165 mL) was added dropwise to this solution over a period of 0.5 hours. After the dropwise addition, the reaction mixture was slowly warmed to room temperature and stirring was continued for 16 hours. Upon completion of the reaction, the reaction mixture was diluted with 4 M sodium hydroxide solution (400 mL) and subsequently extracted with tert-butyl methyl ether (TBME). All TBME phases were combined, dried with anhydrous magnesium sulfate and finally concentrated under vacuum to give the target product 4-bromo-2-methylpyridine (153). Yield: 14.8 g (92% yield).LC/MS analysis: retention time 0.57 min, mass spectrum (ES+) m/z 172, 174 ([M+H]+).

References

[1] Patent: WO2008/57497, 2008, A2. Location in patent: Page/Page column 292
[2] Patent: WO2007/89669, 2007, A2. Location in patent: Page/Page column 203-204
[3] Patent: WO2008/57469, 2008, A1. Location in patent: Page/Page column 292
[4] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 292
[5] Patent: WO2004/14913, 2004, A2. Location in patent: Page 81-82

4-Bromo-2-methylpyridine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Acetyl bromide Chloroform Phosphorus trichloride Diethyl ether 4-Nitro-2-picoline N-oxide Sodium carbonate

Preparation Products

(4-METHOXY-PYRIDIN-2-YL)-METHANOL 4-METHOXYPICOLINALDEHYDE 4-BROMO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

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4-Bromo-2-methylpyridine Suppliers

Americas 1 Canada 5 China 343 Europe 2 France 2 Germany 8 India 49 Ireland 1 Japan 1 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 14 United States 54 Global 486

JIANGYIN RUISHIPHARM CO.,LIMITED

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Jinan Dexinjia Bio&Tech Co., Ltd

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Jinan Shunyichang new material Co., LTD

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Beijing Hezhicheng Chemical Products Co., Ltd

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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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View Lastest Price from 4-Bromo-2-methylpyridine manufacturers

Watson Biotechnology Co.,Ltd

Product: 4-Bromo-2-methylpyridine 22282-99-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2024-10-09

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Bromo-2-methylpyridine 22282-99-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-04-02

Henan Fengda Chemical Co., Ltd

Product: 4-Bromo-2-methylpyridine 22282-99-1
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

22282-99-1, 4-Bromo-2-methylpyridineRelated Search:

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CHEMBRDG-BB 4014101

2-METHYL-4-BROMOPYRIDINE

4-BROMO-2-METHYLPYRIDINE

4-BROMO-2-METHYL-PYRIDINE HYDROCHLORIDE

4-BROMO-2-METHYL-PYRIDINIUM, CHLORIDE

4-BROMO-2-PICOLINE

4-BROMO-2-PICOLINE HCL

4-BROMO-METHYL-PYRIDINE

4-BROMO-2-PICOLINE 4-BROMO-2-METHYLPYRIDINE

4-BROMO-2-METHYLPYRIDINE (4-BROMO-2-PICOLINE)

2-Methyl-4-Bromopyridine HCl

4-BROMO-2-METHYLPYRIDINE 98%

4-bormo-2-methylpyridine

4-Bromo-2-methylpyridie

2-Picoline, 4-bromo- (6CI,8CI)

Pyridine, 4-bromo-2-methyl-

4-bromo-2-methylpyridine(SALTDATA: 0.95HBr 0.35H2O)

2 - Methyl - 4 - broMide pyridine

4-BroMo-2-Methylpyridine0

2-Methyl-4-broMopyridine, 97+%

4-Bromo-2-methylpyridine &gt

-4-bromopyridine

4-Bromo-2-methylpyridine ISO 9001：2015 REACH

4-Bromo-2-picoline hydrochloride

4-Bromo-2-methylpyridine, 95%

22282-99-1

22287-99-1

C6H6BrNHCl

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Building Blocks

C5 to C6

C6 to C7

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Bromopyridines

Halopyridines

pharmacetical

Aromatics

Boronic Acid

Pyridine Series

Halides

Heterocycles

Pyridine

Pyridines, Pyrimidines, Purines and Pteredines

Heterocyclic Series

Pyridines

Organohalides

Aromatics Compounds