4-Bromo-3-fluorobenzonitrile

Product Name: 4-Bromo-3-fluorobenzonitrile
CAS No.: 133059-44-6
Chemical Name: 4-Bromo-3-fluorobenzonitrile
Synonyms: 4-bromo-3-fluoronitrile;4-BROMO-3-FLUOROBENZONITRILE;3-FLUORO-4-BROMOBENZONITRILE;4-Cyano-2-fluorobromobenzene;4-Bromo-3-fluorobenzonitrile97%;Benzonitrile, 4-bromo-3-fluoro-;4-Bromo-3-fluorobenzonitrile >
CBNumber: CB2287247
Molecular Formula: C7H3BrFN
Formula Weight: 200.01
MOL File: 133059-44-6.mol

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4-Bromo-3-fluorobenzonitrile Property

Melting point:: 54-58 C
Boiling point:: 230.1±20.0 °C(Predicted)
Density: 1.69±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
color: White to Almost white
InChI: InChI=1S/C7H3BrFN/c8-6-2-1-5(4-10)3-7(6)9/h1-3H
InChIKey: QBKXYSXQKRNVRQ-UHFFFAOYSA-N
SMILES: C(#N)C1=CC=C(Br)C(F)=C1
CAS DataBase Reference: 133059-44-6(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 20/21/22-36/37/38-36-22
Safety Statements: 26-36
Hazard Note: Toxic
HazardClass: IRRITANT
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS010530
Product name: 4-bromo-3-fluorobenzonitrile
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $73.1
Updated: 2025/07/31

TCI Chemical

Product number: B4022
Product name: 4-Bromo-3-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $64
Updated: 2025/07/31

TCI Chemical

Product number: B4022
Product name: 4-Bromo-3-fluorobenzonitrile
Purity: >98.0%(GC)
Packaging: 25g
Price: $219
Updated: 2025/07/31

TRC

Product number: B692033
Product name: 4-Bromo-3-fluorobenzonitrile
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

TRC

Product number: B692033
Product name: 4-Bromo-3-fluorobenzonitrile
Packaging: 1g
Price: $55
Updated: 2021/12/16

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4-Bromo-3-fluorobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

4-Bromo-3-fluorobenzonitrile is a fluorobenzonitrile that is used in the preparation of ethylene. This chemical can also be used in the synthesis of pharmaceuticals and dyes. 4-Bromo-3-fluorobenzonitrile has been shown to have antimutagenicity and DNA repair abilities, which are due to its ability to inhibit carcinogen metabolism by binding to the enzyme cytochrome P450 2E1. 4-Bromo-3-fluorobenzonitrile also prevents cross linking of collagen by reacting with amino groups on lysine residues, which leads to a decrease in cardiac toxicity.

Synthesis

63069-50-1

133059-44-6

Step 2: Synthesis of 4-bromo-3-fluorobenzonitrile Sodium sulfite (0.97 g, 14.117 mmol) was added to sulfuric acid (6 mL) in batches at 5 °C, followed by stirring at room temperature for 30 min. The reaction mixture was cooled to 0 °C, acetic acid (9.8 mL) was added slowly and stirring was continued for 5 min. After that, 4-amino-3-fluorobenzonitrile (1.6 g, 11.764 mmol) was added in small portions. The mixture was stirred at room temperature for 1 hour. Subsequently, a solution of copper (I) bromide (2.5 g, 17.647 mmol) was added to the aqueous solution. Hydrobromic acid (6 mL) was added slowly at 10 °C. The resulting mixture was stirred overnight at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, water was added and extracted with ether. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (100-200 mesh) using a hexane solution containing 2% ethyl acetate as eluent, resulting in 4-bromo-3-fluorobenzonitrile (0.8 g, 34.7% yield) as a white solid. Mass spectrum (MS): 201.1 [M + 1].

References

[1] Patent: US2017/291894, 2017, A1. Location in patent: Paragraph 0536-0538

4-Bromo-3-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-3-fluorobenzonitrile Suppliers

Americas 1 China 208 Europe 3 Germany 2 India 6 Italy 1 Japan 1 United Kingdom 12 United States 28 Global 262

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View Lastest Price from 4-Bromo-3-fluorobenzonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Bromo-3-fluorobenzonitrile 133059-44-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-04

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-3-fluorobenzonitrile 133059-44-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-28

Career Henan Chemical Co

Product: 4-Bromo-3-fluorobenzonitrile 133059-44-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

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3-FLUORO-4-BROMOBENZONITRILE

4-BROMO-3-FLUOROBENZONITRILE

4-Bromo-3-fluorobenzonitrile97%

4-Cyano-2-fluorobromobenzene

4-Bromo-3-fluorobenzonitrile &gt

Benzonitrile, 4-bromo-3-fluoro-

4-bromo-3-fluoronitrile

133059-44-6

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Fluorine series