4-Bromo-2-methyl-benzaldehyde

Uses

Product Name: 4-Bromo-2-methyl-benzaldehyde
CAS No.: 24078-12-4
Chemical Name: 4-Bromo-2-methyl-benzaldehyde
Synonyms: 5-Bromo-2-formyltoluene;Methyl-4-bromobenzaldehyde;Benzaldehyde,4-broMo-2-Methyl-;4-Bromo-2-methylbenzaldehyde ,98%;4-BROMO-2-METHYLBENZALDEHYDE >97%;4-Bromo-2-methyl-benzaldehyde, 97%min;5-Bromo-2-formyltoluene, 4-Bromo-o-tolualdehyde
CBNumber: CB81462281
Molecular Formula: C8H7BrO
Formula Weight: 199.04
MOL File: 24078-12-4.mol

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4-Bromo-2-methyl-benzaldehyde Property

Boiling point:: 115-116 °C(Press: 8 Torr)
Density: 1.490±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
form: Solid
Appearance: White to yellow <25°C Solid,>25°C Liquid
InChI: InChI=1S/C8H7BrO/c1-6-4-8(9)3-2-7(6)5-10/h2-5H,1H3
InChIKey: RCBPVESMGNZMSG-UHFFFAOYSA-N
SMILES: C(=O)C1=CC=C(Br)C=C1C

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Safety

HS Code: 29122990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B808095
Product name: 4-Bromo-2-methylbenzaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR60101
Product name: 4-Bromo-2-methylbenzaldehyde
Packaging: 5g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 075965
Product name: 4-Bromo-2-methylbenzaldehyde
Purity: 95+%
Packaging: 5g
Price: $38
Updated: 2021/12/16

Matrix Scientific

Product number: 075965
Product name: 4-Bromo-2-methylbenzaldehyde
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

Apolloscientific

Product number: OR60101
Product name: 4-Bromo-2-methylbenzaldehyde
Packaging: 1g
Price: $15
Updated: 2021/12/16

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4-Bromo-2-methyl-benzaldehyde Chemical Properties,Usage,Production

Uses

4-Bromo-2-methylbenzaldehyde has a wide range of chemical transformation properties and can be used as an intermediate in organic synthesis, for example, it can be used in the preparation of progesterone receptor modulators.

Chemical Properties

solid

Chemical Reactivity

4-Bromo-2-methyl-benzaldehyde is an organic compound that can be synthesized by the transfer hydrogenation of 2-methylcyclohexanone. It is used as an additive in the production of polymers and plastics. Its catalytic properties make it a good candidate for use as a hydrogenation catalyst and in sustainable chemical synthesis.

Synthesis

17100-58-2

24078-12-4

Procedure for the synthesis of 4-bromo-2-methylbenzaldehyde: Oxalyl chloride (249 mL, 497 mmol) was dissolved in dichloromethane (150 mL) under argon protection and cooled to -78 °C. A dichloromethane solution (75 mL) of dimethyl sulfoxide (DMSO, 42.4 mL, 597 mmol) was slowly added dropwise through a vent needle, taking care to control the rate of dropwise acceleration to avoid violent outgassing. After dropwise addition, the venting needle was removed and the reaction mixture continued to be stirred at -78 °C for 30 min. Subsequently, a dichloromethane solution (203 mL) of (4-bromo-2-methylphenyl)methanol (28A, 20.0 g, 99.0 mmol) was added and stirred for 30 min at -78 °C. Next, triethylamine (TEA, 166 mL, 1190 mmol) was slowly added dropwise and the reaction mixture was gradually warmed to room temperature and stirring was continued for 12 hours. After completion of the reaction, the organic layer was separated by diluting the reaction mixture with dichloromethane (30 mL) and water (20 mL). The aqueous layer was extracted with dichloromethane (3 x 50 mL), the organic phases were combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated. Purification of the crude product by fast chromatography afforded the target compound 4-bromo-2-methylbenzaldehyde (28B, 15.4 g, 78 mmol, 78% yield) as a yellow oil.1H NMR (400 MHz, CDCl3) δ 10.22 (s, 1H), 7.66 (d, J = 8.28 Hz, 1H), 7.51 (dd, J = 8.28, 1.76 Hz, 1H). 1.76 Hz, 1H), 7.45 (s, 1H), 2.65 (s, 3H).

References

[1] Patent: WO2014/78608, 2014, A1. Location in patent: Paragraph 00281
[2] Patent: WO2015/171757, 2015, A1. Location in patent: Page/Page column 55
[3] Journal of Medicinal Chemistry, 1984, vol. 27, # 11, p. 1516 - 1531
[4] Patent: WO2008/91681, 2008, A2. Location in patent: Page/Page column 225
[5] Patent: US2010/16298, 2010, A1. Location in patent: Page/Page column 191

4-Bromo-2-methyl-benzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-methyl-benzaldehyde Suppliers

China 144 France 1 India 5 United Kingdom 2 United States 13 Global 165

Shanghai Harvest Chemical Industrial Co., Ltd.

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Beijing Eternalchem Co,. Ltd.

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View Lastest Price from 4-Bromo-2-methyl-benzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Bromo-2-methyl-benzaldehyde 24078-12-4
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%HPLC
Supply Ability: 2000tons
Release date: 2020-01-15

Honest Joy Holdings Limited

Product: 4-Bromo-2-methylbenzaldehyde 24078-12-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.9%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: 4-Bromo-2-methyl-benzaldehyde 24078-12-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

24078-12-4, 4-Bromo-2-methyl-benzaldehydeRelated Search:

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5-Bromo-2-formyltoluene, 4-Bromo-o-tolualdehyde

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4-Bromo-2-methyl-benzaldehyde, 97%min

24078-12-4