4-Bromo-2-methylbenzoic acid

Product Name: 4-Bromo-2-methylbenzoic acid
CAS No.: 68837-59-2
Chemical Name: 4-Bromo-2-methylbenzoic acid
Synonyms: 4-Bromo-2-methyL;Fluralaner-038;RARECHEM AL BO 0455;4-Bromo-2-methylbenz;4-Bromo-o-toluic acid;Fluralaner Impurity 58;4-Bromo-2-methylbenzoic;5-Bromo-2-carboxytoluene;4-Bromo-2-methylbenzoicaci;4-Brom-2-methylbenzoic acid
CBNumber: CB0188342
Molecular Formula: C8H7BrO2
Formula Weight: 215.04
MOL File: 68837-59-2.mol

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4-Bromo-2-methylbenzoic acid Property

Melting point:: 180-184 °C
Boiling point:: 310.1±30.0 °C(Predicted)
Density: 1.599±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 3.63±0.25(Predicted)
form: powder to crystal
color: White to Almost white
Water Solubility: Insoluble in water.
BRN: 2249816
InChI: InChI=1S/C8H7BrO2/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4H,1H3,(H,10,11)
InChIKey: RVCJOGNLYVNRDN-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(Br)C=C1C
CAS DataBase Reference: 68837-59-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37/39-36
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT
PackingGroup: Ⅲ
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 665126
Product name: 4-Bromo-2-methylbenzoic acid
Purity: 97%
Packaging: 5g
Price: $84
Updated: 2023/06/20

Sigma-Aldrich

Product number: 665126
Product name: 4-Bromo-2-methylbenzoic acid
Purity: 97%
Packaging: 25g
Price: $268
Updated: 2023/06/20

TCI Chemical

Product number: B3337
Product name: 4-Bromo-2-methylbenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $129
Updated: 2025/07/31

TCI Chemical

Product number: B3337
Product name: 4-Bromo-2-methylbenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $643
Updated: 2025/07/31

Sigma-Aldrich

Product number: 665126
Product name: 4-Bromo-2-methylbenzoic acid
Purity: 97%
Packaging: 100g
Price: $605
Updated: 2023/06/20

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4-Bromo-2-methylbenzoic acid Chemical Properties,Usage,Production

Chemical Properties

White to brown crystal powde

Uses

A building block which is used in preparation of anthranilic acids possessing antibacterial activity. 4-bromo-2-methylbenzoic acid could be used to synthesis 4-chloro-3'-(2-cyclopentyl-1-oxoisoindolin-5-yl)biphenyl-3-carboxylic acid through Suzuki couplings[1].

Synthesis

67832-11-5

68837-59-2

General procedure for the synthesis of 2-methyl-4-bromobenzoic acid from 4-bromo-2-methylbenzonitrile: 4-bromo-2-methylbenzonitrile (1 mmol) was suspended in water (49 mL) and potassium hydroxide (50 mmol) was added. The reaction mixture was stirred overnight under reflux conditions. Upon completion of the reaction, it was cooled to room temperature and the basic aqueous solution was washed with ethyl acetate (3 x 15 mL) to remove unreacted material. Subsequently, the aqueous phase was acidified to pH < 2 with 6 M hydrochloric acid and the acidified aqueous phase was extracted with ethyl acetate (3 x 15 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the white solid product 2-methyl-4-bromobenzoic acid. Yield: 60%. Thin Layer Chromatography (TLC) analysis (unfolding agent: dichloromethane/methanol = 9:1): Rf = 0.46. melting point: 182 °C. 1H-NMR (300 MHz, CD3OD) δ (ppm): 7.80 (d, J = 8.4 Hz, 1H, H-6), 7.48 (s, 1H, H-3), 7.42 (d, J = 8.4 Hz, 1H, H- 5), 2.56 (s, H- 5), 2.56 (s, H- 5), 2.56 (s, H- 5). 5), 2.56 (s, 3H, CH3).

References

[1] Shyama Sidique. “Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence.” Journal of Medicinal Chemistry 55 22 (2012): 9434–9445.

4-Bromo-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-methylbenzoic acid Suppliers

Americas 1 China 309 Europe 3 Germany 6 India 42 Japan 2 Switzerland 2 United Kingdom 9 United States 30 Global 404

Shanghai Harvest Chemical Industrial Co., Ltd.

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INTATRADE GmbH

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View Lastest Price from 4-Bromo-2-methylbenzoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Bromo-2-methylbenzoic acid 68837-59-2
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500KGS
Release date: 2021-07-02

Hebei Fengjia New Material Co., Ltd

Product: 4-Bromo-2-methylbenzoic acid 68837-59-2
Price: US $3.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2024-08-16

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-2-methylbenzoic acid 68837-59-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-10-30

68837-59-2, 4-Bromo-2-methylbenzoic acidRelated Search:

Methyl 2-bromobenzoate 3-BROMO-2-METHYLBENZOIC ACID 3-(Trifluoromethyl)benzoic acid m-Toluic acid 3-Bromoanisole p-Toluic acid o-Toluic acid 4-Bromobenzoic acid Methyl 4-(bromomethyl)benzoate 4-Bromomethylbenzoic acid 4-BROMO-3-METHYLBENZOIC ACID 2-BROMO-3-METHYLBENZOIC ACID 4-Bromoanisole 4-BROMOCINNAMIC ACID Methyl 4-methylbenzoate bis(2-ethylhexyl) tetrabromophthalate 4-HYDROXY-2-METHYLBENZOIC ACID 98 3-Amino-4-methylbenzoic acid

RARECHEM AL BO 0455

2-METHYL-4-BROMOBENZOIC ACID

4-BROMO-2-METHYLBENZOIC ACID

4-Bromo-o-toluic acid

4-Bromo-2-methylbenzoic acid, 98+%

4-Bromo-2-Methylbenzoic Acid 2-Methyl-4-Bromobenzoic Acid

4-Bromo-2-methyL

4-Bromo-2-methylbenz

5-Bromo-2-carboxytoluene

4-BroMo-2-Methylbenzoic Acid, 97+%

4-Brom-2-methylbenzoic acid

Benzoicacid, 4-bromo-2-methyl-

5-Bromo-2-carboxytoluene, 4-Bromo-o-toluic acid

4-Bromo-2-methylbenzoic Acid &gt

4-Bromo-2-methylbenzoicaci

4-Bromo-2-methylbenzoic

Fluralaner-038

4-bromo-2-methylbezoic acid

Fluralaner Impurity 58

68837-59-2

68838-59-2

Building Blocks

C8

Carbonyl Compounds

Carboxylic Acids

Organic Building Blocks

C8

Carbonyl Compounds

Carboxylic Acids

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Benzoic acid

bc0001