4-Bromo-2-methyl-benzaldehyde
Uses- Product Name
- 4-Bromo-2-methyl-benzaldehyde
- CAS No.
- 24078-12-4
- Chemical Name
- 4-Bromo-2-methyl-benzaldehyde
- Synonyms
- 5-Bromo-2-formyltoluene;Methyl-4-bromobenzaldehyde;Benzaldehyde,4-broMo-2-Methyl-;4-Bromo-2-methylbenzaldehyde ,98%;4-BROMO-2-METHYLBENZALDEHYDE >97%;4-Bromo-2-methyl-benzaldehyde, 97%min;5-Bromo-2-formyltoluene, 4-Bromo-o-tolualdehyde
- CBNumber
- CB81462281
- Molecular Formula
- C8H7BrO
- Formula Weight
- 199.04
- MOL File
- 24078-12-4.mol
4-Bromo-2-methyl-benzaldehyde Property
- Boiling point:
- 115-116 °C(Press: 8 Torr)
- Density
- 1.490±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- form
- Solid
- Appearance
- White to yellow <25°C Solid,>25°C Liquid
- InChI
- InChI=1S/C8H7BrO/c1-6-4-8(9)3-2-7(6)5-10/h2-5H,1H3
- InChIKey
- RCBPVESMGNZMSG-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=C(Br)C=C1C
Safety
- HS Code
- 29122990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B808095
- Product name
- 4-Bromo-2-methylbenzaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR60101
- Product name
- 4-Bromo-2-methylbenzaldehyde
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 075965
- Product name
- 4-Bromo-2-methylbenzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- 075965
- Product name
- 4-Bromo-2-methylbenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- OR60101
- Product name
- 4-Bromo-2-methylbenzaldehyde
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
4-Bromo-2-methyl-benzaldehyde Chemical Properties,Usage,Production
Uses
4-Bromo-2-methylbenzaldehyde has a wide range of chemical transformation properties and can be used as an intermediate in organic synthesis, for example, it can be used in the preparation of progesterone receptor modulators.
Chemical Properties
solid
Chemical Reactivity
4-Bromo-2-methyl-benzaldehyde is an organic compound that can be synthesized by the transfer hydrogenation of 2-methylcyclohexanone. It is used as an additive in the production of polymers and plastics. Its catalytic properties make it a good candidate for use as a hydrogenation catalyst and in sustainable chemical synthesis.
Synthesis
17100-58-2
24078-12-4
Procedure for the synthesis of 4-bromo-2-methylbenzaldehyde: Oxalyl chloride (249 mL, 497 mmol) was dissolved in dichloromethane (150 mL) under argon protection and cooled to -78 °C. A dichloromethane solution (75 mL) of dimethyl sulfoxide (DMSO, 42.4 mL, 597 mmol) was slowly added dropwise through a vent needle, taking care to control the rate of dropwise acceleration to avoid violent outgassing. After dropwise addition, the venting needle was removed and the reaction mixture continued to be stirred at -78 °C for 30 min. Subsequently, a dichloromethane solution (203 mL) of (4-bromo-2-methylphenyl)methanol (28A, 20.0 g, 99.0 mmol) was added and stirred for 30 min at -78 °C. Next, triethylamine (TEA, 166 mL, 1190 mmol) was slowly added dropwise and the reaction mixture was gradually warmed to room temperature and stirring was continued for 12 hours. After completion of the reaction, the organic layer was separated by diluting the reaction mixture with dichloromethane (30 mL) and water (20 mL). The aqueous layer was extracted with dichloromethane (3 x 50 mL), the organic phases were combined, washed sequentially with water and brine, dried over anhydrous magnesium sulfate, filtered and concentrated. Purification of the crude product by fast chromatography afforded the target compound 4-bromo-2-methylbenzaldehyde (28B, 15.4 g, 78 mmol, 78% yield) as a yellow oil.1H NMR (400 MHz, CDCl3) δ 10.22 (s, 1H), 7.66 (d, J = 8.28 Hz, 1H), 7.51 (dd, J = 8.28, 1.76 Hz, 1H). 1.76 Hz, 1H), 7.45 (s, 1H), 2.65 (s, 3H).
References
[1] Patent: WO2014/78608, 2014, A1. Location in patent: Paragraph 00281
[2] Patent: WO2015/171757, 2015, A1. Location in patent: Page/Page column 55
[3] Journal of Medicinal Chemistry, 1984, vol. 27, # 11, p. 1516 - 1531
[4] Patent: WO2008/91681, 2008, A2. Location in patent: Page/Page column 225
[5] Patent: US2010/16298, 2010, A1. Location in patent: Page/Page column 191
4-Bromo-2-methyl-benzaldehyde Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-Bromo-2-methyl-benzaldehyde manufacturers
- Product
- 4-Bromo-2-methyl-benzaldehyde 24078-12-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
- Product
- 4-Bromo-2-methylbenzaldehyde 24078-12-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.9%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 4-Bromo-2-methyl-benzaldehyde 24078-12-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-14