ChemicalBook > CAS DataBase List > 2-Benzofurancarboxylic acid ethyl ester

2-Benzofurancarboxylic acid ethyl ester

Product Name
2-Benzofurancarboxylic acid ethyl ester
CAS No.
3199-61-9
Chemical Name
2-Benzofurancarboxylic acid ethyl ester
Synonyms
Ethyl CouMarilate;RARECHEM AL BI 0556;Ethyl 2-benzofurancarboxylate;ethyl benzofuran-2-carboxylate;Ethyl 1-benzofuran-2-carboxylate;Ethyl benzo[b]furan-2-carboxylate;Ethyl benzo[b]furan-2-carboxylate 97%;BENZOFURAN-2-CARBOXLIC ACID ETHYL ESTER;BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER;2-BENZOFURANCARBOXYLIC ACID, ETHYL ESTER
CBNumber
CB4414494
Molecular Formula
C11H10O3
Formula Weight
190.2
MOL File
3199-61-9.mol
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2-Benzofurancarboxylic acid ethyl ester Property

Melting point:
166-170℃
Boiling point:
105°/0.1mm
Density 
1.1656
refractive index 
1.5640 (estimate)
Flash point:
>110℃
storage temp. 
2-8°C
form 
solid
CAS DataBase Reference
3199-61-9(CAS DataBase Reference)
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Safety

Hazard Codes 
T
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2932190090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
763632
Product name
Ethyl benzofuran-2-carboxylate
Purity
97%
Packaging
1g
Price
$30.2
Updated
2023/06/20
TRC
Product number
E904900
Product name
EthylCoumarilate
Packaging
2.5g
Price
$160
Updated
2021/12/16
SynQuest Laboratories
Product number
2H23-1-X1
Product name
Ethylbenzo[b]furan-2-carboxylate
Purity
97%
Packaging
1g
Price
$108
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB33202
Product name
Benzofuran-2-carboxylic acid ethyl ester
Packaging
500mg
Price
$130
Updated
2021/12/16
AK Scientific
Product number
N531
Product name
Benzofuran-2-carboxylicacidethylester
Packaging
10g
Price
$134
Updated
2021/12/16
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2-Benzofurancarboxylic acid ethyl ester Chemical Properties,Usage,Production

Uses

Ethyl Coumarilate has been used as a reactant for the preparation of benzofuropyridines that have a high affinity for the α2-adrenoceptor.

Preparation

Synthesis of ethyl benzofuran-2-carboxylate: Salicylaldehyde (20.0 mL, 0.164 mol) and diethyl bromomalonate (40.0 mL, 0.168 mol) in ethyl methyl ketone (40.0 mL, 0.555 mol) was treated with anhydrous potassium carbonate (20.0 g,0.869 mol). The reaction mixture was refluxed for 18 h on steam bath. Ethyl methyl ketone was distilled off under reduced pressure and the residue formed was dissolved in 400 mL of water and cooled in an ice-bath. It was acidified with dil H2SO4. The product formed was extracted with 25 mL portion of solvent ether twice and the extract was washed with sodium bicarbonate solution. It was dried over calcium chloride. Solvent was removed and the residue ethyl benzofuran-2-carboxylate was dried.

Synthesis Reference(s)

Tetrahedron Letters, 27, p. 6315, 1986 DOI: 10.1016/S0040-4039(00)87796-5

2-Benzofurancarboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Sodium hydride Potassium carbonate 2-Butanone Salicylaldehyde Diethyl ether Dimethyl sulfoxide Diethyl malonate Cupric bromide

Preparation Products

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View Lastest Price from 2-Benzofurancarboxylic acid ethyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Benzofurancarboxylic acid ethyl ester 3199-61-9
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-09
Career Henan Chemical Co
Product
2-Benzofurancarboxylic acid ethyl ester 3199-61-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

3199-61-9, 2-Benzofurancarboxylic acid ethyl esterRelated Search:

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