ChemicalBook > CAS DataBase List > 4-Cloromethyl-5-methyl-1,3-dioxol-2-one

4-Cloromethyl-5-methyl-1,3-dioxol-2-one

Product Name
4-Cloromethyl-5-methyl-1,3-dioxol-2-one
CAS No.
80841-78-7
Chemical Name
4-Cloromethyl-5-methyl-1,3-dioxol-2-one
Synonyms
DMDO-CL;4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE;Olmesartan impurity;4-ChloroMethyl-5-Methyl-1;AZATMint-C;Olmesartan Impurity 3;Olmesartan Impurity 57;Olmesartan Medoxomil IMP;4,5- dinmethyl-1,3-dioxol-2-;4-Chloromethyl-5-Methyl-1,3-Di
CBNumber
CB4416605
Molecular Formula
C5H5ClO3
Formula Weight
148.54
MOL File
80841-78-7.mol
More
Less

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Property

Boiling point:
>90℃/2mm
Density 
1.362±0.06 g/cm3(Predicted)
refractive index 
1.4760-1.4820
Flash point:
129 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
liquid
color 
Colorless to Light yellow to Light orange
Specific Gravity
1.36
BRN 
4798926
InChI
InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
InChIKey
QCLFSYYUWPUWQR-UHFFFAOYSA-N
SMILES
CC1=C(OC(=O)O1)CCl
CAS DataBase Reference
80841-78-7(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29329990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
C1882
Product name
4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity
>94.0%(GC)
Packaging
5g
Price
$85
Updated
2024/03/01
TCI Chemical
Product number
C1882
Product name
4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity
>94.0%(GC)
Packaging
25g
Price
$312
Updated
2024/03/01
Alfa Aesar
Product number
H55735
Product name
4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging
1g
Price
$56.65
Updated
2024/03/01
Alfa Aesar
Product number
H55735
Product name
4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging
5g
Price
$189.65
Updated
2024/03/01
Alfa Aesar
Product number
H55735
Product name
4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging
250mg
Price
$19.3
Updated
2023/06/20
More
Less

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Description

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide. 

Chemical Properties

Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.

Uses

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.

Preparation

4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Suppliers

Americas 1 Canada 4 China 422 Europe 4 France 1 Germany 7 India 90 Japan 4 Switzerland 2 Ukraine 1 United Kingdom 13 United States 53 Global 602
Sansheng Pharmaceutical Industrial Co.,Ltd.
Tel
0373-3329121 15716685442
Fax
0373-3329121
Email
1658822522@qq.com
Country
China
ProdList
7
Advantage
58
TaiZhou ZhiCheng Chemicals & Technology Co., LTD.
Tel
0523-82837785 13914525028
Fax
0523-87913272
Email
info@jszchg.com
Country
China
ProdList
249
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7191
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Wuhan Kemi-Works Chemical Co., Ltd
Tel
027-85736489
Fax
86-27-85736485
Email
info@kemiworks.net
Country
China
ProdList
540
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Shanghai Fuhe Chemistry Technology Co., Ltd.
Tel
0086-21-67651709
Fax
0086-21-67651705
Email
cfx759@hotmail.com
Country
China
ProdList
410
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2871
Advantage
58
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4496
Advantage
50
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Candia Thamtech Company Limited
Tel
0371-86615086 18203638366 0371-86159066 13526786601
Fax
0371-86159066
Country
China
ProdList
2015
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
China Nobel Chem Co., Limited
Tel
+86(0)21 60484900
Fax
+86(0)21 60484900
Country
China
ProdList
764
Advantage
50
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-13526885213 15637198702
Fax
0371-63709726
Email
xpkchem@163.com
Country
China
ProdList
3990
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9346
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Hecheng Advanced Materials Co.,Ltd
Tel
+86-25-58815588
Fax
+86-25-84372983
Email
sale@hcch.net.cn
Country
China
ProdList
20
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5875
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Hefei HomeSunshine Pharmaceutical Technology Co., Ltd.
Tel
0551-65523315 17705606359
Fax
0551-65523375
Email
errol@homesunshinepharma.com
Country
China
ProdList
71
Advantage
58
More
Less

View Lastest Price from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kgs
Release date
2021-09-29
airuikechemical co., ltd.
Product
4-cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08
Hebei Ganmiao New material Technology Co., LTD
Product
4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20ton
Release date
2024-06-05

80841-78-7, 4-Cloromethyl-5-methyl-1,3-dioxol-2-oneRelated Search:

4-Methyl-2-pentanone Mesotrione Methyl cellulose Kresoxim-methyl Methylparaben Norgestrel Bensulfuron methyl METSULFURON METHYL Methyl acrylate 4,5-Dimethyl-1,3-dioxol-2-one 4-Bromomethyl-5-methyl-1,3-dioxol-2-one N-Methyl-2-pyrrolidone tert-Butyldimethylsilyl chloride Methanol Cyclopentene Olmesartan Olmesartan Methyl

  • DMDO-CL
  • 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
  • Olmesartan Impurity 57
  • 4-CloroMethyl-5-Methyl-1,3-dioxol-2-one (DMDO-Cl)
  • OlMesartan IMpurity (4-(ChloroMethyl)-5-Methyl-1,3-Dioxol-2-one)
  • 4- chloroMethyl-5- Methyl-1,3- two oxygenheterocyclicpentadiene-2- ketone
  • -5--1,3- two4-chloroMethylMethylcyclopentene-2- ketoneheterocyclic oxygen
  • 4-ChloroMethyl-5-Methyl-l,3-dioxocyclopenten-2–one
  • DMDO-CL: 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
  • Olmesartan impurity
  • Olmesartan Medoxomil IMP
  • AZATMint-C
  • 4-( Cyclomethyl carbonyl ) -5 - methyl – 1,3-dioxol-2-one ( OLM 45 )
  • Olmesartan Impurity 3
  • 4-Cloromethyl-5-methyl-1,3-dioxol-2-one in stock Factory
  • Olmesartan Medoxomil Impurity 56
  • Olmesartan Medoxomil Impurity 5
  • 4-CHLOROMETHYL-5-METHYL-2-OXO-1,3-DIOXOLE
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOLEN-2-ONE
  • DMDO CL (4-METHYL-5-CHLOROMETHYL-1,3-DIOXOL-2-ONE)
  • 4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(Dmdo-Cl)
  • 4-Chloromethyl-5-Methyl-1,3-Dioxocyclopenten-2-one
  • 4-Chloromethyl-5-methyl-2H-1,3-dioxol-2-one
  • 4-Choromethyl-5-methyl-2-oxo-1,3-dioxole
  • 4-Chloromethyl-5-Methyl-1,3-Di
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-3-ONE
  • 4-methyl-5-chloro methyl-1,3-dioxol-2-one
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE (INTERMEDIATE OF OLMESARTAN MEDOXOMIL)
  • 4-Chloromethyl-5-methyl-1,3-dioxol-2-on
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE HPLC 95%
  • 4-Methyl-5-(chloromethyl)-1,3-dioxole-2-one
  • 4-ChloroMethyl-5-Methyl-1
  • 4-chloroMethyl-5-Methyl-1,3-dioxdene-2-one
  • (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Chloride
  • 4-(chloroMethyl)-5-Methyl-1,3-dioxol-2-oneSynonyMs
  • 1,3-Dioxol-2-one, 4-(chloromethyl)-5-methyl-
  • Olmesartan Medoxomil Impurity 5 (4-(Chloromethyl)-5-methyl-1,3-Dioxol-2-one)
  • 4-Chloromethyl-5-methyl-1,3-dioxol-2-one &gt
  • Olmesartan Chloromethyl Impurity
  • Olmesartan Medoxomil EP Impurity
  • 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ISO 9001：2015 REACH
  • 4-chloromethyl-5-methyl-1,3-Dioxol-2-oneQ: What is 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the CAS Number of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the storage condition of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What are the applications of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one
  • 4-CHLORO METHYL-5-METHYL-1,3-DAIOXOL,2-ONE(DMDO.CL)
  • 4,5- dinmethyl-1,3-dioxol-2-
  • 4-ChlDMDO-Cloromethyl-5-methyl-1,3-dioxol-2-one
  • 4-Chloromethyl-5-methyl-1,3-Dioxole -2-one (DMDO CL)
  • Olmesartan Medoxomil Impurity 5 (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Chloride
  • 4-Chloromethyl-5-MethyI-1 ,3-Diox0l-2-One(DMDO-CI)
  • 4-Chlomethyl-5-methy1-1,3,dioxol-2-one
  • 80841-78-7
  • C5H5ClO3
  • C5H5O3Cl
  • Carbonates
  • Carbonyl Compounds
  • Organic Building Blocks
  • Pharmaceutical Intermediates
  • INTERMEDIATESOF