2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE

Product Name: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE
CAS No.: 312749-73-8
Chemical Name: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE
Synonyms: CLP-3094;EU-0033941;ZINC02074828;BAS 00450541;AH-034/34344061;CLP-3094, 10 mM in DMSO;2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE;2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE;2-[2-(4-chlorophenoxy)ethylsulfanyl]-1H-benzimidazole;1H-Benzimidazole, 2-[[2-(4-chlorophenoxy)ethyl]thio]-
CBNumber: CB4417228
Molecular Formula: C15H13ClN2OS
Formula Weight: 304.79
MOL File: Mol file

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2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Property

storage temp.: RT
solubility: Soluble in DMSO (up to 45 mg/ml)
form: solid
color: Off-white
Stability:: Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 066588
Product name: 2-{[2-(4-Chlorophenoxy)ethyl]thio}-1H-benzimidazole
Packaging: 500mg
Price: $119
Updated: 2021/12/16

Crysdot

Product number: CD11147489
Product name: 2-((2-(4-Chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazole
Purity: 97%
Packaging: 1g
Price: $872
Updated: 2021/12/16

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2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Chemical Properties,Usage,Production

Description

GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR139.1 Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine.2?CLP-3094? (312749-73-8) was identified as a potent and selective GPR142 antagonist with an IC50=2.3 μM against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.3

Uses

CLP-3094 is a potent BF3 (binding function 3)-directed inhibitor of the androgen receptor (AR). CLP-3094 inhibits AR transcriptional activity (IC50=4 μM)[1]. CLP-3094 is a selective, potent GPR142 antagonist[2].

in vivo

CLP-3094 (30, 100 mg/kg; i.p. daily from Day 0 to Day 11) consistently displayed sig-nificantly lower severity of arthritis scores than vehicletreated mice^[2].

Animal Model:	CAIA mouse model (Female DBA1/J mice were i.v. administered with2 mg of anti-collagen antibody, followed by i.p. administration of 50 μg of LPS)^[2]
Dosage:	30, 100 mg/kg
Administration:	I.p. daily from Day 0 to Day 11
Result:	Dose-dependently reduced, by not much, the arth-ritis scores.

References

[1] UTE SÜSENS. Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development[J]. Neuropharmacology, 2006, 50 4: Pages 512-520. DOI:10.1016/j.neuropharm.2005.11.003
[2] MIKE LIZARZABURU . Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22 18: Pages 5942-5947. DOI:10.1016/j.bmcl.2012.07.063
[3] MICHIKO MURAKOSHI. Discovery and pharmacological effects of a novel GPR142 antagonist[J]. Journal of Receptors and Signal Transduction, 2017, 87 1: 290-296. DOI:10.1080/10799893.2016.1247861

2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE Suppliers

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312749-73-8, 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLERelated Search:

Tigecycline ML335 Levetiracetam Pomalidomide

AH-034/34344061

BAS 00450541

EU-0033941

ZINC02074828

2-[2-(4-chlorophenoxy)ethylsulfanyl]-1H-benzimidazole

2-[2-(4-Chloro-phenoxy)-ethylsulfanyl]-1H-benzoimidazole

2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BENZIMIDAZOLE

1H-Benzimidazole, 2-[[2-(4-chlorophenoxy)ethyl]thio]-

CLP-3094

2-((2-(4-Chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazole

2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE

LNCaP,Inhibitor,Androgen Receptor,CLP3094,inhibit,prostate,CLP 3094,resistance,CLP-3094,antiandrogens,cancer

CLP-3094, 10 mM in DMSO

312749-73-8