ChemicalBook > CAS DataBase List > GS-441524

GS-441524

Product Name
GS-441524
CAS No.
1355149-45-9
Chemical Name
GS-441524
Synonyms
GS-443902;2-ethylbutyl ((S)-(((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate;R-32-GS-441524;Remdesivir Impurity 11;Remdesivir triphosphate;Triphosphate / Redesivir-TP;R-32-GS-441524 Triphosphate;Remdesivir Nucleoside Triphosphate;GS 441524 triphosphate triethylammonium salt;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(tetrahydrogen triphosphate)
CBNumber
CB44189084
Molecular Formula
C12H16N5O13P3
Formula Weight
531.2
MOL File
1355149-45-9.mol
More
Less

GS-441524 Property

Density 
2.39±0.1 g/cm3(Predicted)
pka
0.97±0.50(Predicted)
form 
Solid
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
INB0010012
Product name
GS-443902
Purity
95.00%
Packaging
5MG
Price
$456.33
Updated
2021/12/16
ChemScene
Product number
CS-0101780
Product name
GS-443902
Purity
99.87%
Packaging
1mg
Price
$980
Updated
2021/12/16
ChemScene
Product number
CS-0101780
Product name
GS-443902
Purity
99.87%
Packaging
5mg
Price
$1950
Updated
2021/12/16
ChemScene
Product number
CS-0101780
Product name
GS-443902
Purity
99.87%
Packaging
10mg
Price
$2950
Updated
2021/12/16
More
Less

GS-441524 Chemical Properties,Usage,Production

Uses

GS 441524 Triphosphate is known to strongly inhibit feline peritonitis which is a highly lethal coronavirus disease in cats. Also useful in the potential treatment of ebola and emerging viruses.

Definition

ChEBI: GS-443902 is an organic triphosphate that is GS-441524 in which the 5'-hydroxy group has been replaced by a triphosphate group. It is the active metabolite of remdesivir. It has a role as a drug metabolite, an antiviral drug and an anticoronaviral agent. It is a C-nucleoside, an aromatic amine, a nitrile, a pyrrolotriazine and an organic triphosphate. It is functionally related to a GS-441524.

Application

GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats. Remdesivir was never tested in cats (though some vets now offer it), but GS-441524 has been found to be effective treatment for FIP and is widely used despite no official FDA approval due to Gilead's refusal to license this drug for veterinary use.

Advantages

GS-441524 is either similar to or more potent than remdesivir against SARS-CoV-2 in cell culture, with some researchers arguing that GS-441524 would be better than remdesivir for the treatment of COVID-19. Specific advantages cited include ease of synthesis, lower kidney and hepatotoxicity, as well as potential for oral delivery (which is precluded of remdesivir because of poor hepatic stability and first pass metabolism). The public health advocacy group, Public Citizen, in an open letter urged the DHHS and Gilead to investigate GS-441524 for the treatment of COVID-19, suggesting that GILEAD was not doing so for financial motives related to the longer intellectual property lifespan of Remdesivir. Direct efficacy against SARS-CoV-2 was demonstrated in a mouse model of COVID-19. A deuterium modified version of GS-441524 has been produced and has shown pre-clinical efficacy in both cell culture and mouse models by a team including members of Wuhan Institute of Virology.

GS-441524 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

GS-441524 Suppliers

Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
4000
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2964
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
SHANDONG ZHI SHANG CHEMICAL CO.LTD
Tel
+86 18953170293
Fax
+86 0531-67809011
Email
sales@sdzschem.com
Country
China
ProdList
2930
Advantage
58
Hebei Zhanyao Biotechnology Co. Ltd
Tel
15369953316 +8615369953316
Email
admin@zhanyaobio.com
Country
China
ProdList
2123
Advantage
58
Qiuxian Baitai New Material Co., LTD
Tel
+8618330912755
Fax
+8619932103556
Email
sale2@hbyalin.com
Country
China
ProdList
1658
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233717@qq.com
Country
China
ProdList
9919
Advantage
12
Shanghai Lanle Bird Industrial Co., Ltd.
Tel
15021845385
Email
765325601@qq.com
Country
China
ProdList
3609
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3600
Advantage
58
Tianjin shijia biomedical technology co., LTD
Tel
15022261580
Email
tjshj1212@163.com
Country
China
ProdList
2510
Advantage
58
Jinan blalong chemical co. LTD
Tel
2710913286@.com
Email
1513643261@qq.com
Country
China
ProdList
14246
Advantage
58
Shanghai Payne Pharmaceutical Technology Co.Ltd
Tel
021-58123769 17721400256
Email
info@paynepharm.com
Country
China
ProdList
1285
Advantage
58
Shanghai Payne Pharmaceutical Technology Co.Ltd
Tel
021-58123769 18678586262
Email
info@paynepharm.com
Country
China
ProdList
1354
Advantage
58
Shenzhen ruikai de biotechnology co., ltd.
Tel
0755-61348847 17820674378
Fax
0755-21016893
Email
2682116078@qq.com
Country
China
ProdList
7843
Advantage
58
Shanghai Jiegu Biotechnology Co., Ltd.
Tel
021-51698675
Email
jiejiegroup@126.com
Country
China
ProdList
4273
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ:3283937693
Email
sales@ubiochem.com
Country
China
ProdList
4297
Advantage
58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd
Tel
15317229551
Fax
QQ:3607245178
Email
15151849396@163.com
Country
China
ProdList
994
Advantage
58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD
Tel
0755-0755-0755-83725350 13380397412
Fax
0755-28094224
Email
3001280422@qq.com
Country
China
ProdList
10005
Advantage
58
Wuhan Topule
Tel
+86-02787215551 +86-19945035818
Fax
027-87215551
Email
2936752263@qq.com
Country
China
ProdList
7973
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3056
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Hubei Kele Fine Chemical Co., Ltd
Tel
027-59101668 19945030958
Fax
027-59101668
Email
2881924765@qq.com
Country
China
ProdList
8140
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
Email
info@bwtlab.com
Country
China
ProdList
9268
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd
Tel
18102736234 18102736234
Email
2208093734@qq.com
Country
China
ProdList
7664
Advantage
58
Shanghai jerryxing Biomedical Technology Co., Ltd
Tel
17721492509
Email
643638326@qq.com
Country
China
ProdList
5345
Advantage
58
Nantong Hanfang Biotechnology Co. , Ltd.
Tel
18616537568
Email
hanfangpharma@126.com
Country
China
ProdList
30961
Advantage
58
Hubei Moco Chemical Co., Ltd.
Tel
18627753421 18576690171
Fax
QQ:3001051413
Email
3001009495@qq.com
Country
China
ProdList
11192
Advantage
58
TLC Pharmaceutical Standards Ltd.
Tel
18012923235
Email
chinasales04@tlcstandards.com.cn
Country
China
ProdList
4925
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
32957
Advantage
60
Shanghai Likang New Materials Co., Limited
Tel
+86-16631818819 +86-17736933208
Email
3684455296@qq.com
Country
China
ProdList
9300
Advantage
58
Shenzhen Nexconn Pharmatechs Ltd
Tel
+86-755-89396905 +86-15013857715
Email
admin@nexconn.com
Country
China
ProdList
10310
Advantage
58
Wuhan Topule Biopharmaceutical Co., Ltd
Tel
+8618327326525
Email
masar@topule.com
Country
China
ProdList
8467
Advantage
58
China National Standard Pharmaceutical Corporation Limited
Tel
+8615391658522
Email
overseasales@yongstandards.com
Country
China
ProdList
11922
Advantage
58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3135
Advantage
58
Shenzhen Shengda Pharma Limited
Tel
755-85269922 +8613424394241
Fax
WeChat:shengdapharm
Email
sales@shengdapharm.com
Country
CHINA
ProdList
310
Advantage
58
Wisdom Drugs Co .,Ltd
Tel
+86-0519-85556805
Email
Sales3@wisdomdrugs.com
Country
China
ProdList
357
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
More
Less

View Lastest Price from GS-441524 manufacturers

Qiuxian Baitai New Material Co., LTD
Product
gs-441524 1355149-45-9
Price
US $25.00-20.00/PCS
Min. Order
10PCS
Purity
99%
Supply Ability
20000000pcs
Release date
2021-07-09

1355149-45-9, GS-441524Related Search:


  • GS-443902
  • (((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid
  • 2-ethylbutyl ((S)-(((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
  • Triphosphate / Redesivir-TP
  • R-32-GS-441524
  • R-32-GS-441524 Triphosphate
  • Remdesivir Impurity 11
  • ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogentriphosphate
  • D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(tetrahydrogen triphosphate)
  • Remdesivir Nucleoside Triphosphate
  • GS 441524 triphosphate triethylammonium salt
  • Remdesivir triphosphate
  • 1355149-45-9