ChemicalBook > CAS DataBase List > GS-441524

GS-441524

Product Name
GS-441524
CAS No.
1355149-45-9
Chemical Name
GS-441524
Synonyms
GS-443902;2-ethylbutyl ((S)-(((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate;R-32-GS-441524;Remdesivir Impurity 11;Remdesivir triphosphate;Triphosphate / Redesivir-TP;R-32-GS-441524 Triphosphate;Remdesivir Nucleoside Triphosphate;GS 441524 triphosphate triethylammonium salt;D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(tetrahydrogen triphosphate)
CBNumber
CB44189084
Molecular Formula
C12H16N5O13P3
Formula Weight
531.2
MOL File
1355149-45-9.mol
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GS-441524 Property

Density 
2.39±0.1 g/cm3(Predicted)
pka
0.97±0.50(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
INB0010012
Product name
GS-443902
Purity
95.00%
Packaging
5MG
Price
$456.33
Updated
2021/12/16
ChemScene
Product number
CS-0101780
Product name
GS-443902
Purity
99.87%
Packaging
1mg
Price
$980
Updated
2021/12/16
ChemScene
Product number
CS-0101780
Product name
GS-443902
Purity
99.87%
Packaging
5mg
Price
$1950
Updated
2021/12/16
ChemScene
Product number
CS-0101780
Product name
GS-443902
Purity
99.87%
Packaging
10mg
Price
$2950
Updated
2021/12/16
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GS-441524 Chemical Properties,Usage,Production

Uses

GS 441524 Triphosphate is known to strongly inhibit feline peritonitis which is a highly lethal coronavirus disease in cats. Also useful in the potential treatment of ebola and emerging viruses.

Definition

ChEBI: GS-443902 is an organic triphosphate that is GS-441524 in which the 5'-hydroxy group has been replaced by a triphosphate group. It is the active metabolite of remdesivir. It has a role as a drug metabolite, an antiviral drug and an anticoronaviral agent. It is a C-nucleoside, an aromatic amine, a nitrile, a pyrrolotriazine and an organic triphosphate. It is functionally related to a GS-441524.

Application

GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats. Remdesivir was never tested in cats (though some vets now offer it), but GS-441524 has been found to be effective treatment for FIP and is widely used despite no official FDA approval due to Gilead's refusal to license this drug for veterinary use.

Advantages

GS-441524 is either similar to or more potent than remdesivir against SARS-CoV-2 in cell culture, with some researchers arguing that GS-441524 would be better than remdesivir for the treatment of COVID-19. Specific advantages cited include ease of synthesis, lower kidney and hepatotoxicity, as well as potential for oral delivery (which is precluded of remdesivir because of poor hepatic stability and first pass metabolism). The public health advocacy group, Public Citizen, in an open letter urged the DHHS and Gilead to investigate GS-441524 for the treatment of COVID-19, suggesting that GILEAD was not doing so for financial motives related to the longer intellectual property lifespan of Remdesivir. Direct efficacy against SARS-CoV-2 was demonstrated in a mouse model of COVID-19. A deuterium modified version of GS-441524 has been produced and has shown pre-clinical efficacy in both cell culture and mouse models by a team including members of Wuhan Institute of Virology.

GS-441524 Preparation Products And Raw materials

Raw materials

Preparation Products

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GS-441524 Suppliers

Shanghai Sphchem Co., Ltd.
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View Lastest Price from GS-441524 manufacturers

Qiuxian Baitai New Material Co., LTD
Product
gs-441524 1355149-45-9
Price
US $25.00-20.00/PCS
Min. Order
10PCS
Purity
99%
Supply Ability
20000000pcs
Release date
2021-07-09

1355149-45-9, GS-441524Related Search:


  • GS-443902
  • (((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl)triphosphoric acid
  • 2-ethylbutyl ((S)-(((2R,3S,4R,5S)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
  • Triphosphate / Redesivir-TP
  • R-32-GS-441524
  • R-32-GS-441524 Triphosphate
  • Remdesivir Impurity 11
  • ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogentriphosphate
  • D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(tetrahydrogen triphosphate)
  • Remdesivir Nucleoside Triphosphate
  • GS 441524 triphosphate triethylammonium salt
  • Remdesivir triphosphate
  • 1355149-45-9