ChemicalBook > CAS DataBase List > AMCINONIDE

AMCINONIDE

Product Name
AMCINONIDE
CAS No.
51022-69-6
Chemical Name
AMCINONIDE
Synonyms
Amicla;Visderm;cl-34699;Amciderm;Ansinede;Penticort;Amcinonid;cyclocort;Amcinopol;AMCINONIDE
CBNumber
CB4419202
Molecular Formula
C28H35FO7
Formula Weight
502.57
MOL File
51022-69-6.mol
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AMCINONIDE Property

Melting point:
>216°C (dec.)
Boiling point:
635.9°C (rough estimate)
Density 
1.33±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.5860 (estimate)
storage temp. 
-20°C Freezer
solubility 
Acetonitrile (Slightly), Dichlomethane (Slightly), Dioxane (Slightly), Methanol
pka
13.09±0.70(Predicted)
form 
Solid
color 
White to Off-White
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Safety

WGK Germany 
2
RTECS 
TU3682500
HS Code 
2937220000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1019202
Product name
Amcinonide
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$381
Updated
2024/03/01
Cayman Chemical
Product number
23903
Product name
Amcinonide
Purity
≥98%
Packaging
50mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
23903
Product name
Amcinonide
Purity
≥98%
Packaging
100mg
Price
$60
Updated
2024/03/01
Cayman Chemical
Product number
23903
Product name
Amcinonide
Purity
≥98%
Packaging
250mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
23903
Product name
Amcinonide
Purity
≥98%
Packaging
500mg
Price
$213
Updated
2024/03/01
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AMCINONIDE Chemical Properties,Usage,Production

Originator

Cyclocort,Lederle,US,1979

Uses

antiinflammatory

Uses

Glucocorticoid.

Definition

ChEBI: Amcinonide is a corticosteroid, an 11beta-hydroxy steroid, a fluorinated steroid, a 20-oxo steroid, an acetate ester, a spiroketal and a 3-oxo-Delta(1),Delta(4)-steroid. It has a role as an anti-inflammatory drug. It derives from a hydride of a pregnane.

Manufacturing Process

An 11.1 g (24.1 mmol) portion of the compound 16α,17α- cyclopentylidenedioxy-9α-fluoro-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione is placed in a 250 ml round-bottom flask. A 100 ml portion of pyridine is added and the mixture is stirred to a complete solution. A 5.5 ml (54.6 mmol) portion of acetic anhydride is added dropwise and the mixture is stirred for 2% hours. An 11 ml portion of methanol is added and the mixture is stirred an additional hour. This mixture is concentrated under reduced pressure to about 10 to 15 ml and then poured slowly into a mixture of ice, water and dilute hydrochloric acid. This mixture is stirred and the solid which forms is collected by filtration, washed with water to a neutral pH and air dried yielding 11.5 g. This solid is taken up in hot acetone, treated with activated charcoal and filtered while hot through diatomaceous earth. The filtrate is concentrated on a steam bath while adding n-hexane to the point of incipient crystallization. This mixture is allowed to cool to room temperature. The solid which forms is collected by filtration, washed with acetone-n-hexane (1:14) and air dried yielding 7.0 g of the desired product.

brand name

Cyclocort (Astellas.

Therapeutic Function

Topical corticosteroid, Antiinflammatory

General Description

Amcinonide, 21-(acetyloxy)-16α,17-[cyclopentylidenebis(oxy)]-9-fluoro-11β-hydroxypregna-1,4-diene-3,20-dione (Cyclocort).

AMCINONIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMCINONIDE Suppliers

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51022-69-6, AMCINONIDERelated Search:

Vanillin Aprepitant BECLOMETHASONE Rimonabant (r)-budesonide Ancitabine (S)-Glyceraldehyde acetonide Triamcinolone acetonide Descinolone amcinafal AMCINONIDE Triamcinolone Isoflupredone Acetate 1,1-DIMETHOXYCYCLOPENTANE 1,3-DIMETHOXYACETONE CYCLOPENTANONE ETHYLENE KETAL 6(R),7-ISOPROPYLIDENE-HEPTANOL 2,2-Dimethyl-4-hexyl-1,3-dioxolane

  • AMCINONIDE
  • (11-beta,16-alpha)-fluoro-11-hydroxy
  • 20-dione,21-(acetyloxy)-16,17-(cyclopentylidenebis(oxy))-9-pregna-4-diene-3
  • cl-34699
  • cyclocort
  • Amciderm
  • Amcinonid
  • Penticort
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-, (11β,16α)-
  • Spiro[cyclopentane-1,8'-[2H]naphth[2',1':4,5]indeno[1,2-d][1,3]dioxole], pregna-1,4-diene-3,20-dione deriv.
  • Visderm
  • Amcinopol
  • Amicla
  • Amcinonide (200 mg)H0D3460.995mg/mg(ai)
  • Amcinonide (200 mg)
  • 2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-fluoro-7'-hydroxy-6a',8a'-dimethyl-4'-oxo-2',4',6a',6b',7',8',8a',8b',11a',12',12a',12b'-dodecahydro-1'H-spiro[cyclopentane-1,10'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole]-8b'-yl)-2-oxoethyl acetate
  • Amcinonide Solution, 100ppm
  • (11β,16α)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxypregna-1,4-diene-3,20-dione
  • (11alpha,16alpha)-21-(Acetyloxy)-16,17-[cyclopentylidenebis(oxy)]-9-fluoro-11-hydroxy-pregna-1,4-diene-3,20-dione
  • Amcinonide (1019202)
  • Ann's sinai
  • Glucocorticoid Receptor,CL34699,CL 34699,inhibit,Amcinonide,Inhibitor
  • Ansinede
  • 2-((6a'S,6b'R,7'S,8a'S,8b'S,11a'R,12a'S,12b'S)-6b'-Fluoro-7'-hydroxy-6a',8a'-dimethyl-4'-oxo-1',2',4',6a',6b',7',8',8a',11a',12',12a',12b'-dodecahydro-8b'H-spiro[cyclopentane-1,10'-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxole]-8b'-yl)-2-oxoethyl acetate
  • 51022-69-6
  • C28H35FO7
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