Isoflupredone Acetate
- Product Name
- Isoflupredone Acetate
- CAS No.
- 338-98-7
- Chemical Name
- Isoflupredone Acetate
- Synonyms
- predef;U-6013;biorinil;NSC 12600;NSC 37977;Predef R 2X;IsoflupredineAcetate;21-Acetoxy-9-fluoro-;Isoflupredone acetate;Nintedanib Impurity 156
- CBNumber
- CB9500538
- Molecular Formula
- C23H29FO6
- Formula Weight
- 420.47
- MOL File
- 338-98-7.mol
Isoflupredone Acetate Property
- Melting point:
- 244-246° (dec)
- alpha
- D23 +108° (c = 0.735 in dioxane)
- Boiling point:
- 576.5±50.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly), Ethanol (Slightly)
- pka
- 12.05±0.70(Predicted)
- form
- Solid
- color
- White to Off-White
- InChIKey
- ZOCUOMKMBMEYQV-BZIJPSHGNA-N
- SMILES
- [C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)C |&1:0,10,12,14,17,19,22,r|
Safety
- HS Code
- 2937220000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I816610
- Product name
- IsoflupredoneAcetate
- Packaging
- 500mg
- Price
- $790
- Updated
- 2021/12/16
- Product number
- API0010029
- Product name
- ISOFLUPREDONE ACETATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1871.1
- Updated
- 2021/12/16
- Product number
- API0010029
- Product name
- ISOFLUPREDONE ACETATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $739.2
- Updated
- 2021/12/16
Isoflupredone Acetate Chemical Properties,Usage,Production
Uses
Isoflupredone Acetate is an anti-inflammatory drug used in veterinary medicine. It is a corticosteroid with both glucocorticoid and mineralocorticoid activity and has been shown to increase the frequency of severe hypokalemia in healthy cows.
Definition
ChEBI: 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate is a corticosteroid hormone.
Veterinary Drugs and Treatments
Isoflupredone acetate is a potent glucocorticoid and like other glucocorticoids
can be used for its antiinflammatory or immunosuppressive
effects. Labeled indications for isoflupredone include: adjunctive
treatment of bovine ketosis, alleviating pain and lameness
associated with musculoskeletal conditions, acute hypersensitivity
reactions, adjunctive treatment of overwhelming infections with
severe toxicity, shock, supportive therapy in the treatment of stress
conditions (e.g., surgery), dystocia, retained placenta, inflammatory
ocular conditions, snakebite and parturient paresis.
In horses, isoflupredone has been used parenterally to reduce
inflammation associated with recurrent airway obstruction (RAO,
“heaves”, COPD).
While the drug could be used in small animals, it is recommended
to use other glucocorticoid agents instead, where there has been
more experience and other approved products for dogs and cats are
available.
in vivo
Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline.html" class="link-product" target="_blank">Oxytetracycline (HY-B0275)[2].
| Animal Model: | 96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)[2] |
| Dosage: | 0.05 mg/kg |
| Administration: | i.m.; on days 2 and 4 after the challenge |
| Result: | Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers. Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275). |
Toxics Screening Level
The ITSL for Isoflupredone Acetate is 0.01 μg/m3 based on annual averaging.
Isoflupredone Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Isoflupredone Acetate Suppliers
- Tel
- 020-87317062 13048089691
- 852378519@qq.com
- Country
- China
- ProdList
- 198
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12984
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9815
- Advantage
- 79
- Tel
- 021-58958002 18930822973
- Fax
- +86 (21) 5895-8628
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 998
- Advantage
- 58
- Tel
- Country
- China Hong Kong
- ProdList
- 878
- Advantage
- 55
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- sales@njromanme.com
- Country
- China
- ProdList
- 4529
- Advantage
- 58
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8000
- Advantage
- 62
View Lastest Price from Isoflupredone Acetate manufacturers
- Product
- Isoflupredone Acetate 338-98-7
- Price
- US $32.00-1.30/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-28
- Product
- Isoflupredone Acetate 338-98-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-15
- Product
- Isoflupredone Acetate 338-98-7
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10