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Isoflupredone

Product Name
Isoflupredone
CAS No.
338-95-4
Chemical Name
Isoflupredone
Synonyms
9-FLUOROPREDNISOLONE;NSC 12174;ISOFLUPREDONE;DELTAFLUDROCORTISONE;9α-Fluoro-1-cortisol;9a-fluoroprednisolone;Isoflupredone USP/EP/BP;Isoflupredone in Methanol;9-ALPHA-FLUOROPREDNISOLONE;Isoflupredone in Acetonitrile
CBNumber
CB6440732
Molecular Formula
C21H27FO5
Formula Weight
378.43
MOL File
338-95-4.mol
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Isoflupredone Property

Melting point:
260-262°C (dec.)
alpha 
D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried)
Boiling point:
566.7±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
form 
Solid
pka
12.10±0.70(Predicted)
color 
White to Pale Brown
InChIKey
WAIJIHDWAKJCBX-MPVZUUJONA-N
SMILES
[C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)CO |&1:0,10,12,14,17,19,22,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
I816600
Product name
Isoflupredone
Packaging
10mg
Price
$180
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006926
Product name
ISOFLUPREDONE
Purity
95.00%
Packaging
1MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006926
Product name
ISOFLUPREDONE
Purity
95.00%
Packaging
10MG
Price
$1871.1
Updated
2021/12/16
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Isoflupredone Chemical Properties,Usage,Production

Description

Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1].

Chemical Properties

White Solid

Originator

Isoflupredon,Farmabios

Uses

Isoflupredone is an anti-inflammatory.  Isoflupredone could  be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3].

Definition

ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid.

Manufacturing Process

A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for 24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α- fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
The product is extracted with chloroform and isolated by evaporation to dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene- 11β,17α,21-triol-3.20-dione as a solid.

Therapeutic Function

Glucocorticoid

References

[1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
[2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
[3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512.

Isoflupredone Preparation Products And Raw materials

Raw materials

Preparation Products

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Isoflupredone Suppliers

ChengDu SinoStandards Bio-Tech Co.,Ltd. ,
Tel
028-83243028 19136088901
Email
sinostandards@163.com
Country
China
ProdList
4986
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Xunteng International Trading Co.,Limited
Tel
Country
China Hong Kong
ProdList
878
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18043
Advantage
56
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
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View Lastest Price from Isoflupredone manufacturers

Hebei Kangcang new material Technology Co., LTD
Product
9-fluoroprednisolone 338-95-4
Price
US $20.00-10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20
Release date
2024-03-20
Hebei Kangcang new material Technology Co., LTD
Product
9-fluoroprednisolone 338-95-4
Price
US $9.00-60.00/g
Min. Order
10g
Purity
99%
Supply Ability
10 tons
Release date
2024-03-22

338-95-4, IsoflupredoneRelated Search:


  • ISOFLUPREDONE
  • DELTAFLUDROCORTISONE
  • 9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11b)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-
  • 1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE
  • 9-FLUOROPREDNISOLONE
  • 9-ALPHA-FLUOROPREDNISOLONE
  • 9a-fluoroprednisolone
  • (11β)-9-Fluoro-11,17,21-trihydroxy-pregna-1,4-diene-3,20-dione
  • 9-Fluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione
  • 9α-Fluoro-1-cortisol
  • NSC 12174
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-
  • (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Isoflupredone Solution in Acetonitrile, 100μg/mL
  • Isoflupredone USP/EP/BP
  • 1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE
  • Delta-Fluorocortisone|||Isoflupredona|||Isoflupredonum|||9-Fluoroprednisolone
  • (8R,9R,10S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • Isoflupredone in Methanol
  • Isoflupredone in Acetonitrile
  • 338-95-4
  • C21H27FO5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids