ChemicalBook > CAS DataBase List > Isoflupredone

Isoflupredone

Product Name
Isoflupredone
CAS No.
338-95-4
Chemical Name
Isoflupredone
Synonyms
9-FLUOROPREDNISOLONE;NSC 12174;ISOFLUPREDONE;DELTAFLUDROCORTISONE;9α-Fluoro-1-cortisol;9a-fluoroprednisolone;Isoflupredone USP/EP/BP;Isoflupredone in Methanol;9-ALPHA-FLUOROPREDNISOLONE;Isoflupredone in Acetonitrile
CBNumber
CB6440732
Molecular Formula
C21H27FO5
Formula Weight
378.43
MOL File
338-95-4.mol
More
Less

Isoflupredone Property

Melting point:
260-262°C (dec.)
alpha 
D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried)
Boiling point:
566.7±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
form 
Solid
pka
12.10±0.70(Predicted)
color 
White to Pale Brown
InChIKey
WAIJIHDWAKJCBX-MPVZUUJONA-N
SMILES
[C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)CO |&1:0,10,12,14,17,19,22,r|
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
I816600
Product name
Isoflupredone
Packaging
10mg
Price
$180
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006926
Product name
ISOFLUPREDONE
Purity
95.00%
Packaging
1MG
Price
$739.2
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
SHG0006926
Product name
ISOFLUPREDONE
Purity
95.00%
Packaging
10MG
Price
$1871.1
Updated
2021/12/16
More
Less

Isoflupredone Chemical Properties,Usage,Production

Description

Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1].

Chemical Properties

White Solid

Originator

Isoflupredon,Farmabios

Uses

Isoflupredone is an anti-inflammatory.  Isoflupredone could  be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3].

Definition

ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid.

Manufacturing Process

A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for 24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α- fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
The product is extracted with chloroform and isolated by evaporation to dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene- 11β,17α,21-triol-3.20-dione as a solid.

Therapeutic Function

Glucocorticoid

References

[1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
[2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
[3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512.

Isoflupredone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Isoflupredone Suppliers

ChengDu SinoStandards Bio-Tech Co.,Ltd. ,
Tel
028-83243028 19136088901
Email
sinostandards@163.com
Country
China
ProdList
4985
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Xunteng International Trading Co.,Limited
Tel
Country
China Hong Kong
ProdList
878
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
More
Less

View Lastest Price from Isoflupredone manufacturers

Hebei Kangcang new material Technology Co., LTD
Product
9-fluoroprednisolone 338-95-4
Price
US $20.00-10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20
Release date
2024-03-20
Hebei Kangcang new material Technology Co., LTD
Product
9-fluoroprednisolone 338-95-4
Price
US $9.00-60.00/g
Min. Order
10g
Purity
99%
Supply Ability
10 tons
Release date
2024-03-22

338-95-4, IsoflupredoneRelated Search:


  • ISOFLUPREDONE
  • DELTAFLUDROCORTISONE
  • 9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11b)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-
  • 1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE
  • 9-FLUOROPREDNISOLONE
  • 9-ALPHA-FLUOROPREDNISOLONE
  • 9a-fluoroprednisolone
  • (11β)-9-Fluoro-11,17,21-trihydroxy-pregna-1,4-diene-3,20-dione
  • 9-Fluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione
  • 9α-Fluoro-1-cortisol
  • NSC 12174
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-
  • (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Isoflupredone Solution in Acetonitrile, 100μg/mL
  • Isoflupredone USP/EP/BP
  • 1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE
  • Delta-Fluorocortisone|||Isoflupredona|||Isoflupredonum|||9-Fluoroprednisolone
  • (8R,9R,10S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • Isoflupredone in Methanol
  • Isoflupredone in Acetonitrile
  • 338-95-4
  • C21H27FO5
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids