Isoflupredone
- Product Name
- Isoflupredone
- CAS No.
- 338-95-4
- Chemical Name
- Isoflupredone
- Synonyms
- 9-FLUOROPREDNISOLONE;NSC 12174;ISOFLUPREDONE;DELTAFLUDROCORTISONE;9α-Fluoro-1-cortisol;9a-fluoroprednisolone;Isoflupredone USP/EP/BP;9-ALPHA-FLUOROPREDNISOLONE;Isoflupredone Solution in Acetonitrile, 100μg/mL;1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE
- CBNumber
- CB6440732
- Molecular Formula
- C21H27FO5
- Formula Weight
- 378.43
- MOL File
- 338-95-4.mol
Isoflupredone Property
- Melting point:
- 260-262°C (dec.)
- alpha
- D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried)
- Boiling point:
- 566.7±50.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 12.10±0.70(Predicted)
- color
- White to Pale Brown
- InChIKey
- WAIJIHDWAKJCBX-MPVZUUJONA-N
- SMILES
- [C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)CO |&1:0,10,12,14,17,19,22,r|
N-Bromosuccinimide Price
- Product number
- I816600
- Product name
- Isoflupredone
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- SHG0006926
- Product name
- ISOFLUPREDONE
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $739.2
- Updated
- 2021/12/16
- Product number
- SHG0006926
- Product name
- ISOFLUPREDONE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $1871.1
- Updated
- 2021/12/16
Isoflupredone Chemical Properties,Usage,Production
Description
Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1].
Chemical Properties
White Solid
Originator
Isoflupredon,Farmabios
Uses
Isoflupredone is an anti-inflammatory. Isoflupredone could be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3].
Definition
ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid.
Manufacturing Process
A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml
of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml
Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of
Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for
24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α-
fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated
with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The
culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
The product is extracted with chloroform and isolated by evaporation to
dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene-
11β,17α,21-triol-3.20-dione as a solid.
Therapeutic Function
Glucocorticoid
References
[1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
[2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
[3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512.
Isoflupredone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Isoflupredone manufacturers
- Product
- 9-fluoroprednisolone 338-95-4
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20
- Release date
- 2024-03-20
- Product
- 9-fluoroprednisolone 338-95-4
- Price
- US $9.00-60.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-22
- Product
- Isoflupredone 338-95-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-11