Isoflupredone

ChemicalBook > CAS DataBase List > Isoflupredone

Product Name: Isoflupredone
CAS No.: 338-95-4
Chemical Name: Isoflupredone
Synonyms: 9-FLUOROPREDNISOLONE;NSC 12174;ISOFLUPREDONE;DELTAFLUDROCORTISONE;9α-Fluoro-1-cortisol;9a-fluoroprednisolone;9α-Fluoroprednisolone;Isoflupredone USP/EP/BP;Isoflupredone in Methanol;9-ALPHA-FLUOROPREDNISOLONE
CBNumber: CB6440732
Molecular Formula: C21H27FO5
Formula Weight: 378.43
MOL File: 338-95-4.mol

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Isoflupredone Property

Melting point:: 260-262°C (dec.)
alpha: D23 +108° (c = 0.611 in ethanol); D23 +94° (alcohol)(Fried)
Boiling point:: 566.7±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Ethyl Acetate (Slightly)
form: Solid
pka: 12.10±0.70(Predicted)
color: White to Pale Brown
InChIKey: WAIJIHDWAKJCBX-MPVZUUJONA-N
SMILES: [C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)CO |&1:0,10,12,14,17,19,22,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: I816600
Product name: Isoflupredone
Packaging: 10mg
Price: $180
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0006926
Product name: ISOFLUPREDONE
Purity: 95.00%
Packaging: 1MG
Price: $739.2
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: SHG0006926
Product name: ISOFLUPREDONE
Purity: 95.00%
Packaging: 10MG
Price: $1871.1
Updated: 2021/12/16

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Isoflupredone Chemical Properties,Usage,Production

Description

Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1].

Chemical Properties

White Solid

Originator

Isoflupredon,Farmabios

Uses

Isoflupredone is an anti-inflammatory. Isoflupredone could be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3].

Definition

ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid.

Manufacturing Process

A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for 24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α- fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
The product is extracted with chloroform and isolated by evaporation to dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene- 11β,17α,21-triol-3.20-dione as a solid.

Therapeutic Function

Glucocorticoid

References

[1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
[2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
[3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512.

Isoflupredone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isoflupredone manufacturers

Hebei Kangcang new material Technology Co., LTD

Product: 9-fluoroprednisolone 338-95-4
Price: US $20.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20
Release date: 2024-03-20

Hebei Kangcang new material Technology Co., LTD

Product: 9-fluoroprednisolone 338-95-4
Price: US $9.00-60.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-03-22

338-95-4, IsoflupredoneRelated Search:

Prednisone Prednisone 21-acetate Prednisolone TRIS(2,2,2-TRIFLUOROETHYL)ORTHOFORMATE Fluorine Betamethasone DEXAMETHASONE SODIUM PHOSPHATE Betamethasone 21-phosphate disodium Triamcinolone Diflorasone Dexamethasone Flumethasone Fluocinonide Flumethasone 21-pivalate Triamcinolone diacetate Dexamethasone 21-phosphate disodium salt ciprocinonide Flumethasone-17-acetate

ISOFLUPREDONE

DELTAFLUDROCORTISONE

9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11b)-

Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-

1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE

1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE

9-FLUOROPREDNISOLONE

9-ALPHA-FLUOROPREDNISOLONE

9a-fluoroprednisolone

(11β)-9-Fluoro-11,17,21-trihydroxy-pregna-1,4-diene-3,20-dione

9-Fluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione

9α-Fluoro-1-cortisol

NSC 12174

Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-

(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Isoflupredone Solution in Acetonitrile, 100μg/mL

Isoflupredone USP/EP/BP

1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE

Delta-Fluorocortisone|||Isoflupredona|||Isoflupredonum|||9-Fluoroprednisolone

(8R,9R,10S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Isoflupredone in Methanol

Isoflupredone in Acetonitrile

9α-Fluoroprednisolone

Isoflupredone, 10 mM in DMSO

338-95-4

C21H27FO5

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids