ChemicalBook > CAS DataBase List > Isoflupredone Acetate

Isoflupredone Acetate

Product Name
Isoflupredone Acetate
CAS No.
338-98-7
Chemical Name
Isoflupredone Acetate
Synonyms
predef;U-6013;biorinil;NSC 12600;NSC 37977;Predef R 2X;IsoflupredineAcetate;21-Acetoxy-9-fluoro-;Isoflupredone acetate;Nintedanib Impurity 156
CBNumber
CB9500538
Molecular Formula
C23H29FO6
Formula Weight
420.47
MOL File
338-98-7.mol
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Isoflupredone Acetate Property

Melting point:
244-246° (dec)
alpha 
D23 +108° (c = 0.735 in dioxane)
Boiling point:
576.5±50.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Acetone (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly), Ethanol (Slightly)
pka
12.05±0.70(Predicted)
form 
Solid
color 
White to Off-White
InChIKey
ZOCUOMKMBMEYQV-BZIJPSHGNA-N
SMILES
[C@@]12([H])CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)C |&1:0,10,12,14,17,19,22,r|
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Safety

HS Code 
2937220000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
I816610
Product name
IsoflupredoneAcetate
Packaging
500mg
Price
$790
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010029
Product name
ISOFLUPREDONE ACETATE
Purity
95.00%
Packaging
1G
Price
$1871.1
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010029
Product name
ISOFLUPREDONE ACETATE
Purity
95.00%
Packaging
100MG
Price
$739.2
Updated
2021/12/16
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Isoflupredone Acetate Chemical Properties,Usage,Production

Uses

Isoflupredone Acetate is an anti-inflammatory drug used in veterinary medicine. It is a corticosteroid with both glucocorticoid and mineralocorticoid activity and has been shown to increase the frequency of severe hypokalemia in healthy cows.

Definition

ChEBI: 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate is a corticosteroid hormone.

Veterinary Drugs and Treatments

Isoflupredone acetate is a potent glucocorticoid and like other glucocorticoids can be used for its antiinflammatory or immunosuppressive effects. Labeled indications for isoflupredone include: adjunctive treatment of bovine ketosis, alleviating pain and lameness associated with musculoskeletal conditions, acute hypersensitivity reactions, adjunctive treatment of overwhelming infections with severe toxicity, shock, supportive therapy in the treatment of stress conditions (e.g., surgery), dystocia, retained placenta, inflammatory ocular conditions, snakebite and parturient paresis.
In horses, isoflupredone has been used parenterally to reduce inflammation associated with recurrent airway obstruction (RAO, “heaves”, COPD).
While the drug could be used in small animals, it is recommended to use other glucocorticoid agents instead, where there has been more experience and other approved products for dogs and cats are available.

in vivo

Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline.html" class="link-product" target="_blank">Oxytetracycline (HY-B0275)[2].

Animal Model:96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)[2]
Dosage:0.05 mg/kg
Administration:i.m.; on days 2 and 4 after the challenge
Result:Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers. Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).

Toxics Screening Level

The ITSL for Isoflupredone Acetate is 0.01 μg/m3 based on annual averaging.

Isoflupredone Acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Isoflupredone Acetate manufacturers

Henan Fengda Chemical Co., Ltd
Product
Isoflupredone Acetate 338-98-7
Price
US $32.00-1.30/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Dideu Industries Group Limited
Product
Isoflupredone Acetate 338-98-7
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-15
Career Henan Chemical Co
Product
Isoflupredone Acetate 338-98-7
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-10

338-98-7, Isoflupredone AcetateRelated Search:

9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate Fluocinonide ciprocinonide Flumethasone 21-pivalate 6alpha,9-difluoro-11beta-hydroxy-16alpha,17-[isopropylidenebis(oxy)]pregna-1,4-diene-3,20-dione 21-propionate Isoflupredone Acetate Triamcinolone diacetate Dexamethasone-17-acetate Flumethasone-17-acetate AMCINONIDE Difluprednate Diflorasone diacetate Meprednisone Prednisone 21-acetate Isoflupredone Prednisolone Prednisone Prednisolone-21-acetate

  • 4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-pregna-(11-be
  • 4-diene-3,20-dione,9-fluoro-11-beta,17,21-trihydroxy-pregna-21-acetate
  • 9-alpha-fluoroprednisoloneacetate
  • 9-fluoroprednisoloneacetate
  • 9-fluorprednisoloneacetate
  • biorinil
  • predef
  • ISOFLUPREDONE ACETATE (200 MG)
  • isoflupredone 21-acetate
  • 21-Acetoxy-9-fluoro-11,B-17-dihydroxy-pregna-1,4-diene-3,20-dione
  • IsoflupredineAcetate
  • 21-ACETOXY-9-FLUORO-11BETA,17-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIONE
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11.beta.)-
  • 21-acetoxy-9-fluoro-11,17-dihydroxy-pregna-1,4-diene-3,20-dione
  • Isoflupredone acetate
  • 21-ACETOXY-9-FLUORO-11SS,17-DIHYDROXY-PREGNA-1,4-DIENE-3,20-DIONE
  • 21-(Acetyloxy)-9α-fluoro-11β,17α-dihyroxypregna-1,4-diene-3,20-dione
  • U-6013
  • 21-Acetoxy-9-fluoro-
  • 9-Fluoroprednisolone-21-acetate
  • NSC 12600
  • NSC 37977
  • Predef R 2X
  • 2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-diMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • Isoflupredone Acetate USP
  • 9alpha-Fluoro-11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-
  • Isoflupredone Acetate USP/EP/BP
  • Isoflupredone Acetate (1348907)
  • Isofluprednisone acetate
  • 9-Fluoroprednisolone acetate(Isoflupredone acetate)
  • 21-Acetoxy-9-fluoro-11b,17-dihydroxypregna-1,4-dienen-3,20-dione
  • 1, 4-PREGNADIEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE 21-ACETATE
  • Nintedanib Impurity 156
  • Isoflupredone Acetate, 10 mM in DMSO
  • 9-fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
  • Prednisolone Acetate Impurity 6
  • 338-98-7
  • Intermediates & Fine Chemicals
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