7-BENZYLOXY-4-CHLOROQUINOLINE
- Product Name
- 7-BENZYLOXY-4-CHLOROQUINOLINE
- CAS No.
- 178984-56-0
- Chemical Name
- 7-BENZYLOXY-4-CHLOROQUINOLINE
- Synonyms
- 102579;4-chloro-7-(phenylMethoxy;4-chloro-7-benzoxyquinoline;4-chloro-7-phenoxy-quinoline;7-BENZYLOXY-4-CHLOROQUINOLINE;4-chloro-7-phenylmethoxyquinoline;Quinoline, 4-chloro-7-(phenylmethoxy)-;7-BENZYLOXY-4-CHLOROQUINOLINE ISO 9001：2015 REACH
- CBNumber
- CB4420424
- Molecular Formula
- C16H12ClNO
- Formula Weight
- 269.73
- MOL File
- 178984-56-0.mol
7-BENZYLOXY-4-CHLOROQUINOLINE Property
- Boiling point:
- 414.1±30.0 °C(Predicted)
- Density
- 1.263±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.86±0.27(Predicted)
- Appearance
- White to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B700273
- Product name
- 7-(Benzyloxy)-4-chloroquinoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 072748
- Product name
- 7-(Benzyloxy)-4-chloroquinoline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
- Product number
- W3897
- Product name
- 7-(Benzyloxy)-4-chloroquinoline
- Packaging
- 5g
- Price
- $419
- Updated
- 2021/12/16
- Product number
- 072748
- Product name
- 7-(Benzyloxy)-4-chloroquinoline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- PXT0001159
- Product name
- 7-(BENZYLOXY)-4-CHLOROQUINOLINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $631
- Updated
- 2021/12/16
7-BENZYLOXY-4-CHLOROQUINOLINE Chemical Properties,Usage,Production
Synthesis
749922-34-7
178984-56-0
Step 3) Synthesis of 7-(benzyloxy)-4-chloroquinoline: 7-(benzyloxy)quinolin-4-ol (72 g, 287 mmol) was suspended in toluene (134 mL), and phosphorus trichloride (44 g, 287 mmol, source: Tianjin FuChen Chem. Co. Ltd.) was added. The suspension was heated to 120 °C and maintained for 1 hour. After completion of the reaction, the mixture was cooled to 70 °C and diluted with EtOAc (600 mL). The resulting mixture was stirred in an ice bath for 30 min and cooled to 15 °C. Subsequently, the mixture was neutralized with 3M NaOH aqueous solution to pH 7~8, keeping the solution temperature below 20°C during the process. The aqueous layer was separated and the organic layer was extracted with EtOAc. The combined organic layers were washed with brine (200 mL), dried over anhydrous Na2SO4, and concentrated in vacuum to give 7-benzyloxy-4-chloroquinoline as a light yellow solid (70.8 g, 91.6% yield). Mass spectrum (ESI, positive ion mode) m/z: 270.1 [M + 1]; 1H NMR (400 MHz, DMSO-d6) δ: 5.31 (s, 2H), 7.35 (t, 1H), 7.42 (t, J = 7.2Hz, 2H), 7.47 (dd, J = 2.8Hz, J = 9.2Hz, 1H), 7.52 (d, J = 7.6 Hz, 2H), 7.13 (t, J = 4.8 Hz, 2H), 8.11 (d, J = 9.6 Hz, 1H), 8.75 (d, J = 4.8 Hz, 1H).
References
[1] Patent: US2012/219522, 2012, A1. Location in patent: Page/Page column 20
7-BENZYLOXY-4-CHLOROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
7-BENZYLOXY-4-CHLOROQUINOLINE Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 7-BENZYLOXY-4-CHLOROQUINOLINE manufacturers
- Product
- 7-BENZYLOXY-4-CHLOROQUINOLINE 178984-56-0
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-05-23