Copper(II) gluconate Property

Melting point:

155-157 °C(lit.)

Boiling point:

673.6℃[at 101 325 Pa]

Density 

1.777[at 20℃]

vapor pressure 

13.3Pa at 20℃

refractive index 

16.5 ° (C=1, H2O)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Aqueous Acid (Slightly), Water (Sparingly, Sonicated)

form 

powder

color 

Light Blue to Blue

optical activity

[α]26/D +15°, c = 1 in H2O

Water Solubility 

slightly soluble

Merck 

14,2640

Exposure limits

ACGIH: TWA 1 mg/m3
NIOSH: IDLH 100 mg/m3; TWA 1 mg/m3

Stability:

Hygrscopic

LogP

-2.98

CAS DataBase Reference

527-09-3(CAS DataBase Reference)

EPA Substance Registry System

Copper gluconate (527-09-3)

Safety

Safety Statements 

24/25

WGK Germany 

3

RTECS 

LZ5058000

TSCA 

Yes

HS Code 

29181600

Hazardous Substances Data

527-09-3(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Copper(II) gluconate Chemical Properties,Usage,Production

Description

Copper(II) gluconate is the copper salt of D-gluconic acid that is an organic acid. It can be used as a buffer for encapsulating some drugs into liposomes. Copper is an essential microelement for human beings and animals; it is needed to absorb ion from and gut and can help regulate blood pressure and heart rate. It is also a key component of multiple enzymes involved in many biochemical reactions. In this sense, the D-gluconic acid copper (II) salt can be used as a copper supplement to treat the copper deficiency induced anemia and nephrosis. It is also useful in the cancer chemotherapy being capable of enhancing the efficacy of the anticancer drug, disulfiram.

References

Dicko, Awa, et al. "Role of copper gluconate/triethanolamine in irinotecan encapsulation inside the liposomes." International Journal of Pharmaceutics 337.1(2007):219-228.
Ferris Iii, Frederick L, et al. "Nutritional supplement to treat macular degeneration.", EP1516542. 2009.
Georgewill Udeme Owunari, Siminialayi Iyeopu Minakiri. “Disulfiram and Copper gluconate in cancer chemotherapy: a review of the literature.” Cancer Research Journal 2.5(2014):88-92.

Chemical Properties

Copper(II) gluconate, Cu(C6H11O7)2, is a light blue to blue-green, crystalline material that is soluble in water and slightly soluble in ethanol.

Uses

copper gluconate is cited as having skin-conditioning and skinprotecting functions.

Uses

Supplement (trace mineral).

Uses

Copper(II) gluconate is used in dietary supplement. It is also used to treat acne vulgaris, common cold, hypertension, premature labor, leishmaniasis and visceral postoperative complications. Further, it is used in oral deodorants and feed additives. In addition to this, it is used as a synergist and nutritional supplement for foods. It is the active component in retsyn used in mints and certs.

Definition

ChEBI: Copper gluconate is an organic molecular entity.

Preparation

Copper(II) gluconate is prepared by the dissolution of copper(II) carbonate or copper(II) hydroxide in gluconic acid. It is used as a nutritional supplement for copper deficiency and as a component in oral deodorants.

Flammability and Explosibility

Not classified

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.