Trimethyltin hydroxide

Product Name: Trimethyltin hydroxide
CAS No.: 56-24-6
Chemical Name: Trimethyltin hydroxide
Synonyms: trimethylstannanol;trimethylstannylhydroxide;TRIMETHYLTIN(IV) HYDROXIDE;hydroxytrimethylstannane;trimethylhydroxytin;hydroxytrimethyltin;hydroxytrimethyl-ti;rimethyltin,hydrate;trimethyl-tihydroxide;TRIMETHYLTIN HYDROXIDE
CBNumber: CB4440435
Molecular Formula: C3H10OSn
Formula Weight: 180.82
MOL File: 56-24-6.mol

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Trimethyltin hydroxide Property

Melting point:: 118°C
Boiling point:: 80°C
RTECS: WH8400000
Flash point:: 26℃
solubility: Chloroform (Soluble, Sonicated), Methanol (Slightly, Sonicated), Water (Sparingly)
form: Powder
pka: 6.36±0.70(Predicted)
color: White
Water Solubility: Soluble in water.
Sensitive: Moisture Sensitive
Exposure limits: ACGIH: TWA 0.1 mg/m3; STEL 0.2 mg/m3 (Skin)
NIOSH: IDLH 25 mg/m3; TWA 0.1 mg/m3
EPA Substance Registry System: Stannane, hydroxytrimethyl- (56-24-6)

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Safety

Risk Statements: 20/21/22
Safety Statements: 22-36/37/39-45
RIDADR: 3146
HazardClass: 6.1
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS025240
Product name: Trimethylstannanol
Purity: AldrichCPR
Packaging: 100MG
Price: $99.7
Updated: 2024/03/01

Alfa Aesar

Product number: 071167
Product name: Trimethyltin hydroxide, 98%
Packaging: 1g
Price: $69.6
Updated: 2023/06/20

Alfa Aesar

Product number: 071167
Product name: Trimethyltin hydroxide, 98%
Packaging: 5g
Price: $252
Updated: 2023/06/20

Strem Chemicals

Product number: 93-5085
Product name: Trimethyltin hydroxide, 98%
Packaging: 2g
Price: $94
Updated: 2024/03/01

Strem Chemicals

Product number: 93-5085
Product name: Trimethyltin hydroxide, 98%
Packaging: 10g
Price: $375
Updated: 2024/03/01

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Trimethyltin hydroxide Chemical Properties,Usage,Production

Chemical Properties

Trimethyltin hydroxide is a colorless, white crystals. It is soluble in water and many organic solvents. It is commercially available in the form of large, needle-shaped, crystals with a significant propensity for twinning along the needle axis. The twinning of the trimethyltin hydroxide needle shaped crystals makes finding a single crystal for data collection very difficult.

Uses

Trimethyltin hydroxide is used in the synthesis of modified thymines, which is useful as inhibitors of RNase A. It is also used in the preparation of ketoheterocycle inhibitors of fatty acid amide inhibitors. It reacts with 2,2-disubstituted benzothiazolines to form trialkyltin derivatives of sulphur containing Schiff base complexes.

Reactions

The synthesis of N-Boc-N-(2-(tritylthio)ethoxy)glycine (4) is illustrated in Scheme 2. O-(2-(tritylthio)ethyl)hydroxylamine (1) was synthesized using the literature method. The aminooxy group was then protected with Boc, followed by alkylation with methyl bromoacetate in the presence of sodium hydride. Saponification of the methyl ester with trimethyltin hydroxide afforded N-Boc-N-(2-(tritylthio)ethoxy)glycine (4) in an overall yield of 19% after three steps of reactions. The Boc and Trt protecting groups in building block 4 are stable to Fmoc SPPS and are readily removable by treatment with trifluoroacetic acid (TFA).

Hazard

A poison.

References

[1] Anderson, Kirsty M., et al. "Trimethyltin hydroxide: a crystallographic and high Z′ curiosity." Crystal Growth & Design, 2011, 11 3: 820-826. DOI:10.1021/cg101464j.
[2] K. C. NICOLAOU PROF. DR. A Mild and Selective Method for the Hydrolysis of Esters with Trimethyltin Hydroxide?[J]. Angewandte Chemie International Edition, 2005, 44 9: 1378-1382. DOI:10.1002/anie.200462207.
[3] ROBIN K HARRIS Patrick R Kenneth J Packer. High-resolution Tin-119 NMR of solid trimethyltin hydroxide[J]. Journal of Magnetic Resonance (1969), 1985, 61 3: Pages 564-566. DOI:10.1016/0022-2364(85)90199-4.
[4] LINGLING PENG, AIMIN SONG* N-tert-Butoxycarbonyl-N-(2-(tritylthio)ethoxy)glycine as a Building Block for Peptide Ubiquitination[J]. Bioconjugate Chemistry Bioconjugate, 2024, 35 2: 245-253. DOI:10.1021/acs.bioconjchem.3c00541.

Trimethyltin hydroxide Preparation Products And Raw materials

Raw materials

Preparation Products

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Trimethyltin hydroxide Suppliers

China 54 Germany 3 India 2 Japan 1 Russia 1 United Kingdom 3 United States 11 Global 75

Aladdin Scientific

Tel: +1-+1(833)-552-7181
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Alfa Aesar

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Ereztech LLC

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United States Biological

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Strem Chemicals, Inc.

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Pure Chemistry Scientific Inc

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3B Scientific Corporation

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Cardinal Industries

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Pfaltz & Bauer, Inc.

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MP Biomedicals, Inc.

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Prime Organics, Inc.

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56-24-6, Trimethyltin hydroxideRelated Search:

Bis(tributyltin) oxide Triphenyltin acetate Fentin hydroxide TRI-N-BUTYLTIN ACETATE BIS(TRIPHENYLTIN) OXIDE TRI-N-BUTYLTIN METHOXIDE Trimethyltin hydroxide BIS(TRIMETHYLSILYL)TRIBUTYLTINPHOSPHATE TRIBUTYLTIN ETHOXIDE TRIBUTYLTIN SEBACATE tin hydroxide TRIBUTYLTIN SALICYLATE BIS(TRIPROPYL TIN)OXIDE TRIPHENYL TIN-P-ACETAMINO BENZOATE TRIBUTYL(8-QUINOLYLOXY)TIN BIS(TRI-N-BUTYLTIN) ITACONATE TRI-N-BUTYLTIN 2,4-DICHLOROPHENOLATE TRI-N-BUTYLTIN PROPIONATE

trimethylstannylhydroxide

hydroxytrimethyltin

trimethylhydroxytin

trimethylstannanol

trimethyl-tihydroxide

TIN TRIMETHYL HYDROXIDE

Trimethyltinhydroxide,98%

STANNANE,HYDROXYTRIMETHYL-

Hydroxytrimethyltin(IV)

Trimethylstannyl alcohol

Trimethyltin hydroxide, 98% (CH3)3SnOH F.W.180.80

TriMethyltin hydroxide, 98% (CH3)3SnOH

TRIMETHYLTIN HYDROXIDE

TRIMETHYLTIN(IV) HYDROXIDE

hydroxytrimethyl-stannan

hydroxytrimethylstannane

hydroxytrimethyl-ti

Stannane, hydroxytrimethyl- (8CI,9CI)

rimethyltin,hydrate

56-24-6

C3H10OSn

C3H10SnO

CH33SnOH

organotin compound