5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID
- Product Name
- 5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID
- CAS No.
- 10242-02-1
- Chemical Name
- 5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID
- Synonyms
- RARECHEM AL BE 0707;5-Methyl-3-indole acid;5-Methylindole-3-forMicacid;5-METHYLINDOLE-3-CARBOXYLIC ACID;5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylic acid, 5-methyl-
- CBNumber
- CB4444761
- Molecular Formula
- C10H9NO2
- Formula Weight
- 175.18
- MOL File
- 10242-02-1.mol
5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID Property
- Melting point:
- 202 °C
- Boiling point:
- 421.2±25.0 °C(Predicted)
- Density
- 1.340±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.98±0.30(Predicted)
- Appearance
- White to off-white Powder
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M321273
- Product name
- 5-Methyl-1H-indole-3-carboxylicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR913133
- Product name
- 5-Methyl-1H-indole-3-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- X8614
- Product name
- 5-Methyl-1H-indole-3-carboxylicacid
- Packaging
- 10g
- Price
- $357
- Updated
- 2021/12/16
- Product number
- OR913133
- Product name
- 5-Methyl-1H-indole-3-carboxylicacid
- Purity
- 98%
- Packaging
- 5g
- Price
- $363
- Updated
- 2021/12/16
- Product number
- OR913133
- Product name
- 5-Methyl-1H-indole-3-carboxylicacid
- Purity
- 98%
- Packaging
- 10g
- Price
- $580
- Updated
- 2021/12/16
5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
124-38-9
614-96-0
10242-02-1
Lithium tert-butoxide (LiOtBu, 160 mg, 2.00 mmol) and 5-methylindole (23.4 mg, 0.4 mmol) were added to a dry two-necked reaction vessel. The reaction vessel was evacuated by placing it under high vacuum conditions, followed by the passage of carbon dioxide gas (CO2 balloon). After addition of N,N-dimethylformamide (DMF, 2 mL), the reaction mixture was stirred at 100 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and the reaction was carefully quenched with 2N hydrochloric acid (HCl) solution. The reaction mixture was extracted several times with ethyl acetate (EtOAc, 5 x 5 mL). The organic phases were combined, washed sequentially with water (2 × 5 mL) and saturated saline (1 × 5 mL), and dried over anhydrous magnesium sulfate (MgSO4). The dried organic phases were concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography (TLC, Spreading agent: hexane/acetone=1:1) to afford the target product 5-methyl-1H-indole-3-carboxylic acid (153.0 mg, 95% yield) as a white solid.
References
[1] Organic Letters, 2012, vol. 14, # 20, p. 5326 - 5329,4
[2] Heterocycles, 2015, vol. 90, # 2, p. 1196 - 1204
5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID manufacturers
- Product
- 5-METHYL-1H-INDOLE-3-CARBOXYLIC ACID 10242-02-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg；10kg; 25kg
- Release date
- 2020-01-07