10-Hydroxycamptothecin

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10-Hydroxycamptothecin

Product Name: 10-Hydroxycamptothecin
CAS No.: 19685-09-7
Chemical Name: 10-Hydroxycamptothecin
Synonyms: SN38;HCPT;HYDROXYCAMPTOTHECIN;10-HCPT;(S)-10-HYDROXYCAMPTOTHECIN;Ampule;NSC 107124;HYDROCAMPTOTHECINE;hydroxy-camptotheci;Irinotecan USP RC A
CBNumber: CB4445430
Molecular Formula: C20H16N2O5
Formula Weight: 364.35
MOL File: 19685-09-7.mol

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10-Hydroxycamptothecin Property

Melting point:: 265-270°C
Boiling point:: 820.7±65.0 °C(Predicted)
Density: 1.60
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: ≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
pka: 8.93±0.40(Predicted)
form: powder to crystal
color: White to Yellow to Orange
InChIKey: HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS DataBase Reference: 19685-09-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H340May cause genetic defects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2491
Product name: Irinotecan Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 25MG
Price: $485
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1347610
Product name: Irinotecan Related Compound A
Packaging: 10mg
Price: $1490
Updated: 2024/03/01

TCI Chemical

Product number: H1463
Product name: 10-Hydroxycamptothecin
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $231
Updated: 2024/03/01

Cayman Chemical

Product number: 14635
Product name: (S)-10-hydroxy-Camptothecin
Purity: ≥98%
Packaging: 25mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 14635
Product name: (S)-10-hydroxy-Camptothecin
Purity: ≥98%
Packaging: 50mg
Price: $107
Updated: 2024/03/01

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10-Hydroxycamptothecin Chemical Properties,Usage,Production

Description

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC₅₀ = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G₂/M phase.

Chemical Properties

Yellow Solid

Uses

A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

Definition

ChEBI: 10-Hydroxycamptothecin is a pyranoindolizinoquinoline.

in vitro

10-Hydroxycamptothecin inhibited the growth of BT-20 and MDA-231 cells with IC50 of 34.3nM and 7.27nM, respectively, which was more potent than camptothecin (CPT) with IC50>500nM. 10-Hydroxycamptothecin potently induces the formation of the pBR322 plasmid DNA cleavage complex mediated by human topoisomerase I with an EC50 of 0.35 μM, more than 50-fold more potent than CPT with an EC50 of 18.85 μM. 10-Hydroxycamptothecin treatment caused dose-dependent growth inhibition of human microvascular endothelial cells (HMECs) with IC50 of 0.31 μM and significantly inhibited HMEC migration with IC50 of 0.63 μM. Treatment of HMEC cells with 10-Hydroxycamptothecin also inhibited microtubule formation in a dose-dependent manner with IC50 of 0.96 μM. 10-Hydroxycamptothecin (5-20 nM) significantly inhibits the differentiation of Colo205 cells, arrests the cell cycle in G2 phase, and induces apoptosis through a caspase-3-dependent pathway.

in vivo

In the CAM model, 10-Hydroxycamptothecin treatment inhibited angiogenesis in a concentration-dependent manner, with 95% inhibition at 25 nM, more potent than suramin, which inhibited only 60% of angiogenesis at 125 nM. 10-Hydroxycamptothecin, administered orally at low doses of 2.5-7.5 mg/kg every two days, caused significant growth inhibition in Colo205 xenograft mice, but no acute toxicity. LD50: 104 mg/kg in mice (intraperitoneal injection).

IC 50

0.31 μm

References

[1] vladu b, woynarowski jm, manikumar g, wani mc, wall me, von hoff dd, wadkins rm. 7- and 10-substituted camptothecins: dependence of topoisomerase i-dna cleavable complex formation and stability on the 7- and 10-substituents. mol pharmacol. 2000 feb;57(2):243-51.
[2] xiao d, tan w, li m, ding j. antiangiogenic potential of 10-hydroxycamptothecin. life sci. 2001 aug 24;69(14):1619-28.
[3] ping yh, lee hc, lee jy, wu ph, ho lk, chi cw, lu mf, wang jj. anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. oncol rep. 2006 may;15(5):1273-9.

10-Hydroxycamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 10-Hydroxycamptothecin manufacturers

Shanghai Standard Technology Co., Ltd.

Product: 10-Hydroxycamptothecin 19685-09-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-20

Changzhou Rokechem Technology Co., Ltd.

Product: 10-Hydroxycamptothecin 19685-09-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: 1-10000g
Release date: 2022-11-22

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: 10-Hydroxycamptothecin 19685-09-7 19685-09-7
Price: US $15.60/mg
Min. Order: 20mg
Purity: 98.00
Supply Ability: 1000.00 kgs
Release date: 2019-07-09

19685-09-7, 10-HydroxycamptothecinRelated Search:

10-HYDROXYCAMPTOTHECIN 10-Nitrocamptothecin (+)-Camptothecin Irinotecan hydrochloride 7-Ethyl-10-hydroxycamptothecin SN-38 GLUCURONIDE sodium:(2S)-2-[12-ethyl-8-(hydroxymethyl)-9-oxo-2-(4-piperidin-1-ylpiperidine-1-carbonyl)oxy-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoate Irinotecan 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 6 Irinotecan EP Impurity H 12-Hydroxy Irinotecan 7-Ethylcamptothecin Irinotecan EP Impurity K (Mixture of Diastereomers) Irinotecan IMpurity G Irinotecan Impurity 5 RPR 121056 GURKHSYORGJETM-MGDILKBHSA-N

Camptothecae Acuminatae extract

hydrate,(s)-dihydroxy

hydroxy-camptotheci

Hydroxycamptothencine

(20S)-10-HYDROXYCAMPTOTHECIN 98%

(20S)-10-Hydroxycamptothecin

HYDROCAMPTOTHECINE

CAMPTOTHECIN, 10-HYDROXY(SH)

HYDROXYCAMPTOTHECIN, 10-(P)

10-hydroxycamptothecin (TECANS)

10-HYDROCAMPTOTHECIN

Ampule

(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

NSC 107124

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4-ethyl-4,10-dihydroxy-, (4S)-

(4S)-4,9-Dihydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

(S)-10-HYDROXYCAMPTOTHECIN

SN38

10-Hydroxycamptothecin, 98%, from Taxus chinensis (Pilg.) Rehder

10-HCPT

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4,9-dihydroxy-, (4S)-

(S)-10-Hydroxycamptothecin (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Irinotecan USP RC A

Irinotecan Impurity 12

CAMPTOTHECIN, 10-HYDROXY-

CAMPTOTHECIN, 10-HYDROXY-, CAMPTOTHECA ACUMINATA

HCPT

HYDROXYCAMPTOTHECIN

HYDROXYCAMPTOTHECIN, 10-

(20S)-10-HYDROXYCAMPTOTHECIN (20S)-7-ETHYL-10-HYDROXYCAMPTOTHECIN (S)-10-HYDROXYCAMPTOTHECIN

CaMptothecin IMpurity

CaMptothecin 10-Hydroxy IMpurity

10-HydroxycaMptothecin, froM Taxus chinensis

Irinotecan EP Impurity B

10-Hydroxycamptothecin 19685-09-7

(S)-4-ethyl-4,9-dihydroxy-1H-pyrano

10-HYDROXY CAMPTOTHECIN (IRINOTECAN EP IMPURITY B)

Fructus Camptothecae

(s)-10-hydroxycamptothecinhydrate

4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-1h-pyrano(3

4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4,9-dihydroxy-,hydrate,(s)-1h-pyrano(3

(4S)-4α-Ethyl-4,9-dihydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione

(4S)-9-Hydroxy-4-hydroxy-4-ethyl-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

10-Hydroxycamptothecin

10-Hydroxycamptothecine

HYDROXYCAMPTOTHECIN, 10-(RG)

10-hydroxycamptothecin,HCPT

(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione

Irinotecan Related CoMpound A

(+/-)-4-ethyl-4,9-dihydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

Irinotecan Related Compound A (10 mg) ((S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

10-HydroxycaMptothecin, HydroxycaMptothecine

Hydroxycamptothecin 80-98%

(S)-10-Hydroxycamptothecin,>98%

(20S)-10-Hydroxycamptothecine

Camptotheca acuminata fruit extract

(19S)-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione