3',4'-DIHYDROXYPROPIOPHENONE
- Product Name
- 3',4'-DIHYDROXYPROPIOPHENONE
- CAS No.
- 7451-98-1
- Chemical Name
- 3',4'-DIHYDROXYPROPIOPHENONE
- Synonyms
- Dopamine Impurity;Erlotinib Impurity 124;3,4-DIHYDROXYPROPIOPHENONE;3',4'-DIHYDROXYPROPIOPHENONE;3’,4’-dihydroxy-propiophenon;3',4'-DIHYDROXYPROPIOPHENONE;3',4'-Dihydroxypropiophenone,98%;1-(3,4-dihydroxyphenyl)-1-propanon;1-(3,4-Dihydroxyphenyl)-1-propanone;1-(3,4-dihydroxyphenyl)propan-1-one
- CBNumber
- CB4453934
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 7451-98-1.mol
3',4'-DIHYDROXYPROPIOPHENONE Property
- Melting point:
- 145-146°C
- Boiling point:
- 375.1±27.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- pka
- 8.75±0.31(Predicted)
- CAS DataBase Reference
- 7451-98-1(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A13444
- Product name
- 3',4'-Dihydroxypropiophenone, 98%
- Packaging
- 1g
- Price
- $40.65
- Updated
- 2024/03/01
- Product number
- A13444
- Product name
- 3',4'-Dihydroxypropiophenone, 98%
- Packaging
- 5g
- Price
- $144.65
- Updated
- 2024/03/01
- Product number
- D493333
- Product name
- 3'',4''-Dihydroxypropiophenone
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FD71269
- Product name
- 3',4'-Dihydroxypropiophenone
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD71269
- Product name
- 3',4'-Dihydroxypropiophenone
- Packaging
- 10g
- Price
- $50
- Updated
- 2021/12/16
3',4'-DIHYDROXYPROPIOPHENONE Chemical Properties,Usage,Production
Uses
It is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Preparation
Obtained by Fries rearrangement of pyrocatechol dipropio-nate with aluminium chloride in chlorobenzene at 80° for 2 h (84%) or in nitrobenzene at 100° for 15 min;
Obtained by Fries rearrangement of pyrocatechol dipropionate with aluminium chloride in the presence of pyrocatechol, in nitrobenzene at 80° for 1 h (37%) or in nitromethane at r.t. for 72 h (76%)
Also obtained by Fries rearrangement of o-methoxyphenyl propionate (1 mol) by aluminium chloride (2 mol) without solvent at 140° for 2 h (51–55%) or in nitrobenzene at 80° for 30–60 min. A demethylation occurs during the reaction.
Also obtained by acylation of pyrocatechol with propionic acid
in the presence of boron trifluoride, at 150° for 2 h in a sealed tube ? (36%)
in the presence of polyphosphoric acid for 15 min in a boiling water bath ? (12%)
Preparation by demethylation of 4-hydroxy-3-methoxypropiophenone with refluxing pyridinium chloride for 10 min (80%)
Also obtained when propiovanillone was heated with an alkali sulfide under conditions used in the kraft cooking process.
3',4'-DIHYDROXYPROPIOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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