4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Property

Melting point:

234-235℃

storage temp. 

2-8°C

solubility 

H₂O: 7 mg/mL at <40 °C

form 

solid

color 

light tan

Water Solubility 

Soluble to 100 mM in water

Safety

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Chemical Properties,Usage,Production

Description

Immepip is a histamine H₃ receptor agonist (K_I = 0.4 nM in SK-N-MC cell membranes expressing the human receptor). It is selective for histamine H₃ over H₁ and H₂ receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (K_is = >16 μM for both) but also agonizes H₄ receptors (K_I = 9 nM in SK-N-MC cell membranes expressing the human receptor). Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats. It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.

Chemical Properties

Crystalline Solid

Uses

A selective nonchiral histamine H3 agonist.

Biological Activity

Potent histamine H 3 receptor agonist. Also binds to H 4 receptors (K i values are 0.4 and 9 nM at human recombinant H 3 and H 4 receptors respectively). Equipotent to or slightly more active than (R)- α -methylhistamine at H 3 receptors.

storage

Desiccate at RT