ChemicalBook > CAS DataBase List > 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE

4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE

Product Name
4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE
CAS No.
164391-47-3
Chemical Name
4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE
Synonyms
Zinc00005777;Immepip hydrobromide;IMMEPIP DIHYDROBROMIDE;4-(1H-Imidazol-5-ylmethyl)piperidine hydrobromide;4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE;Piperidine,4-(1H-imidazol-4-ylmethyl)-,dihydrobromide
CBNumber
CB4459345
Molecular Formula
C9H17Br2N3
Formula Weight
327.06
MOL File
164391-47-3.mol
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4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Property

Melting point:
234-235℃
storage temp. 
2-8°C
solubility 
H2O: 7 mg/mL at <40 °C
form 
solid
color 
light tan
Water Solubility 
Soluble to 100 mM in water
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I4034
Product name
Immepip dihydrobromide
Purity
≥97% (HPLC), powder
Packaging
10mg
Price
$204
Updated
2024/03/01
Sigma-Aldrich
Product number
I4034
Product name
Immepip dihydrobromide
Purity
≥97% (HPLC), powder
Packaging
50mg
Price
$646
Updated
2024/03/01
Cayman Chemical
Product number
29518
Product name
Immepip (hydrobromide)
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
29518
Product name
Immepip (hydrobromide)
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
29518
Product name
Immepip (hydrobromide)
Packaging
10mg
Price
$160
Updated
2024/03/01
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4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Chemical Properties,Usage,Production

Description

Immepip is a histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor). It is selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor). Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats. It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.

Chemical Properties

Crystalline Solid

Uses

A selective nonchiral histamine H3 agonist.

Biological Activity

Potent histamine H 3 receptor agonist. Also binds to H 4 receptors (K i values are 0.4 and 9 nM at human recombinant H 3 and H 4 receptors respectively). Equipotent to or slightly more active than (R)- α -methylhistamine at H 3 receptors.

storage

Desiccate at RT

4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE Suppliers

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164391-47-3, 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDERelated Search:

4-(IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE

  • 4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE
  • IMMEPIP DIHYDROBROMIDE
  • Zinc00005777
  • 4-(1H-Imidazol-5-ylmethyl)piperidine hydrobromide
  • Immepip hydrobromide
  • Piperidine,4-(1H-imidazol-4-ylmethyl)-,dihydrobromide
  • 164391-47-3
  • C9H17Br2N3
  • C9H15N32HBr
  • 2BrHC9H15N3
  • Inhibitors
  • Histamine receptor