1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile
- Product Name
- 1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile
- CAS No.
- 64169-67-1
- Chemical Name
- 1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile
- Synonyms
- LU 17-046;Citalopram Benzofuran analog;1-(4-Fluorophenyl)-5-cyanophthalan;1-(4-fluorophenyl)-5-phthalane Carbonitr;5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran;1-(4-Fluorophenyl)-1,3-dihydroisobenzofurane-5-cyano;5-Cyano-1- (4-fluorophenyl) -1,2-dihydroisobenzofuran;1-(4-Fluorophenyl)-1,3-dihyrosobenzofuran-5-carbonitrile;1-(4-FLUOROPHENYL)-1,3-DIHYDRO-5-ISOBENZOFURANCARBONITRILE;1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURAN-5-CARBONITRILE
- CBNumber
- CB4465759
- Molecular Formula
- C15H10FNO
- Formula Weight
- 239.24
- MOL File
- 64169-67-1.mol
1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile Property
- Melting point:
- 95-97°C
- Boiling point:
- 375°C
- Density
- 1.29
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Dichloromethane, Methanol (Slightly, Sonicated)
- form
- Solid
- color
- White to Light Yellow
- CAS DataBase Reference
- 64169-67-1(CAS DataBase Reference)
Safety
- HS Code
- 2932.99.7000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0879
- Product name
- 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $29
- Updated
- 2025/07/31
- Product number
- F595710
- Product name
- rac-1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- F595710
- Product name
- rac-1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
- Packaging
- 2g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 094336
- Product name
- 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- 094336
- Product name
- 1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
- Purity
- 95+%
- Packaging
- 5g
- Price
- $303
- Updated
- 2021/12/16
1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
An intermediate in the synthesis of Citalopram.
Synthesis
82104-74-3
7439-95-4
460-00-4
64169-67-1
GENERAL STEPS: A solution of 4-fluorophenylmagnesium bromide was prepared by reacting 153.33 g (0.876 mol) of 4-fluorobenzene bromide, 25.33 g (1.055 mol) of magnesium scrapings and 0.05 g of iodine in 300 mL of anhydrous tetrahydrofuran. This Grignard reagent solution was slowly added to a suspension of 100 g (0.628 mol) 5-cyanophthalide. The reaction was carried out in 1000 mL of dichloromethane and the temperature was maintained at -6 to -2°C. Upon completion of the reaction, post-processing was carried out as in Example 1 to give a thick semi-solid product. This semi-solid was ground with 500 mL of isopropanol (IPA) and cooled at 0-5 °C to give the solid product 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran (2b). The solid was collected by filtration and washed with cold 50 mL IPA. The yield of the product was 130-140 g and the HPLC purity was 99.32%.
References
[1] Patent: WO2004/20425, 2004, A1. Location in patent: Page 11
[2] Patent: WO2004/20425, 2004, A1. Location in patent: Page 13-14
1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile manufacturers
- Product
- 1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile 64169-67-1
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.0%(GC)
- Supply Ability
- 100kg
- Release date
- 2023-07-04
- Product
- 1-(4-Fluorophenyl)-1,3-dihydro isobenzofuran-5-carbonitile 64169-67-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-08-20