GSK-467

Product Name: GSK-467
CAS No.: 1628332-52-4
Chemical Name: GSK-467
Synonyms: GSK-467;cGAS inhibitor 467;GSK467, 10 mM in DMSO;2-((1-Benzyl-1H-pyrazol-4-yl)oxy)pyrido[3,4-d]pyrimidin-4(3H)-one;Pyrido[3,4-d]pyrimidin-4(3H)-one, 2-[[1-(phenylmethyl)-1H-pyrazol-4-yl]oxy]-;HCC,inhibit,GSK 467,GSK467,Histone Demethylase,GSK-467,human multiple myeloma tumor,anticancer,PLU1,Inhibitor,JARID1B
CBNumber: CB44667988
Molecular Formula: C17H13N5O2
Formula Weight: 319.32
MOL File: 1628332-52-4.mol

More

Less

GSK-467 Property

Boiling point:: 560.6±60.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 20.83 mg/mL (65.23 mM);Water : < 0.1 mg/mL (insoluble)
pka: 2.27±0.20(Predicted)
form: Solid
color: White to off-white

More

Less

Safety

HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0066471
Product name: GSK467
Purity: 99.20%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: 3238EM
Product name: 2-[(1-Benzyl-1h-Pyrazol-4-Yl)oxy]pyrido[3,4-D]pyrimidin-4(3h)-One
Packaging: 10mg
Price: $258
Updated: 2021/12/16

ChemScene

Product number: CS-0066471
Product name: GSK467
Purity: 99.20%
Packaging: 10mg
Price: $320
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009828
Product name: 2-[(1-BENZYL-1H-PYRAZOL-4-YL)OXY]-PYRIDO-[3,4-D]PYRIMIDIN-4(3H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $459.16
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573464
Product name: GSK467
Purity: >98%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

More

Less

GSK-467 Chemical Properties,Usage,Production

Uses

GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1][2].

in vivo

GSK-467 can inhibit the proliferation and growth of HCC tumor cells by promoting the expression of miR-448 and inhibiting the YTHDF3/ITGA6 pathway in female BALB/c nude mice^[3].

IC 50

KDM5: 10 nM (Ki); KDM5: 26 nM (IC₅₀)

References

[1] Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45. DOI:10.1038/nchembio.2087
[2] Fu YD, et al. Targeting histone demethylase KDM5B for cancer treatment. Eur J Med Chem. 2020 Dec 15;208:112760. DOI:10.1016/j.ejmech.2020.112760
[3] Guo JC, et al. KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis. J Cell Mol Med. 2021 Apr 7;25(13):5949–62. DOI:10.1111/jcmm.16342

GSK-467 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GSK-467 Suppliers

China 34 United States 2 Global 36

Ningbo Chaoming Biotechnology Co., Ltd

Tel: 13301662590
Email: mandy@atkchemical.com
Country: China
ProdList: 9343
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6312
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1168
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

1628332-52-4, GSK-467Related Search:

RET Kinase inhibitor 1 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK484 GSK583 GSK369796 GSK461364 GSK547 GSK481 GSK-3326595 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

cGAS inhibitor 467

GSK-467

2-((1-Benzyl-1H-pyrazol-4-yl)oxy)pyrido[3,4-d]pyrimidin-4(3H)-one

HCC,inhibit,GSK 467,GSK467,Histone Demethylase,GSK-467,human multiple myeloma tumor,anticancer,PLU1,Inhibitor,JARID1B

Pyrido[3,4-d]pyrimidin-4(3H)-one, 2-[[1-(phenylmethyl)-1H-pyrazol-4-yl]oxy]-

GSK467, 10 mM in DMSO

1628332-52-4