GSK583

Product Name: GSK583
CAS No.: 1346547-00-9
Chemical Name: GSK583
Synonyms: SK583;GSK583;CS-2216;GSK583, >98%;GSK583 ，S8261;GSK-583;GSK 583;GSK583 >=98% (HPLC);GSK583, 10 mM in DMSO;RIP2 kinase inhibitor 583;6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
CBNumber: CB63128826
Molecular Formula: C20H19FN4O2S
Formula Weight: 398.45
MOL File: 1346547-00-9.mol

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GSK583 Property

Boiling point:: 652.9±55.0 °C(Predicted)
Density: 1.402±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in DMSO (up to at least 25 mg/ml).
pka: 12.59±0.40(Predicted)
form: solid
color: Pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI: InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
InChIKey: XLOGLWKOHPIJLV-UHFFFAOYSA-N
SMILES: N1C2C(=CC(S(C(C)(C)C)(=O)=O)=CC=2)C(NC2C3=C(NN=2)C=CC(F)=C3)=CC=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1960
Product name: GSK583
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1960
Product name: GSK583
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $436
Updated: 2025/07/31

Cayman Chemical

Product number: 19739
Product name: GSK583
Purity: ≥98%
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19739
Product name: GSK583
Purity: ≥98%
Packaging: 25mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 19739
Product name: GSK583
Purity: ≥98%
Packaging: 50mg
Price: $183
Updated: 2024/03/01

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GSK583 Chemical Properties,Usage,Production

Description

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50?= 5 nM human and IC50?= 2 nM rat.1?It also potently inhibits isolated RIP3 kinase (IC50?= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2

Uses

GSK 583, is a selective inhibitor of RIP-like interacting CLARP kinase RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.

in vivo

GSK583 (0.1, 1, and 10 mg/kg, p.o.) inhibits serum KC (the rodent orthologue of IL-8) levels in rats in a dose-dependent manner, with an IC₅₀ derived from rat blood concentrations of 50 nM (or 20 ng/mL). Similarly, GSK583 inhibits serum KC levels and recruitment of neutrophils into the peritoneal cavity in mice in a dose-dependent manner, with an IC₅₀ of 37 nM (15 ng/mL) derived from mouse blood concentration^[1].

storage

Store at +4°C

References

[1] PAMELA A. HAILE. The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase[J]. Journal of Medicinal Chemistry, 2016, 59 10: 4867-4880. DOI:10.1021/acs.jmedchem.6b00211
[2] TATIANA GONCHAROV. Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.[J]. Molecular Cell, 2018, 69 4: 551-565.e7. DOI:10.1016/j.molcel.2018.01.016

GSK583 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK583 Suppliers

China 83 India 1 United Kingdom 1 United States 10 Global 95

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
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Suzhou Ran enzyme Biotechnology Co., Ltd.

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Fax: 0512-62793604
Email: 116667374@qq.com
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Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
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Shanghai Boyle Chemical Co., Ltd.

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Fax: 86-21-57758967
Email: sales@boylechem.com
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Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
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Shanghai Topbiochem Technology Co., Ltd

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Email: info@topbiochem.com
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Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
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Email: 3008007409@qq.com
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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View Lastest Price from GSK583 manufacturers

Career Henan Chemical Co

Product: GSK583 1346547-00-9
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

1346547-00-9, GSK583Related Search:

BAY 11-7082 Phytosphingosine Andrographolide Oxaprozin RET Kinase inhibitor 1 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK484 GSK369796 GSK461364 GSK547 GSK-467 GSK481 GSK-3326595 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

GSK583

SK583

6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine

RIP2 kinase inhibitor 583

CS-2216

GSK583, >98%

GSK-583;GSK 583

4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-

GSK583 >=98% (HPLC)

6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine

GSK-583,GSK583,RIPK,Inhibitor,Receptor-interacting protein kinases,RIP kinase,GSK 583,inhibit

GSK583, 10 mM in DMSO

GSK583 ，S8261

1346547-00-9