ChemicalBook > CAS DataBase List > GSK583

GSK583

Product Name
GSK583
CAS No.
1346547-00-9
Chemical Name
GSK583
Synonyms
SK583;GSK583;CS-2216;GSK583, >98%;GSK-583;GSK 583;GSK583 >=98% (HPLC);RIP2 kinase inhibitor 583;6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine;6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine;4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
CBNumber
CB63128826
Molecular Formula
C20H19FN4O2S
Formula Weight
398.45
MOL File
1346547-00-9.mol
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GSK583 Property

Boiling point:
652.9±55.0 °C(Predicted)
Density 
1.402±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in DMSO (up to at least 25 mg/ml).
pka
12.59±0.40(Predicted)
form 
solid
color 
Pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19739
Product name
GSK583
Purity
≥98%
Packaging
10mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
19739
Product name
GSK583
Purity
≥98%
Packaging
25mg
Price
$104
Updated
2024/03/01
Cayman Chemical
Product number
19739
Product name
GSK583
Purity
≥98%
Packaging
50mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
19739
Product name
GSK583
Purity
≥98%
Packaging
100mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
19739
Product name
GSK583
Purity
≥98%
Packaging
250mg
Price
$613
Updated
2021/12/16
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GSK583 Chemical Properties,Usage,Production

Description

GSK583 (1346547-00-9) is a highly selective and potent inhibitor of RIP2 kinase, IC50?= 5 nM human and IC50?= 2 nM rat.1?It also potently inhibits isolated RIP3 kinase (IC50?= 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2

Uses

GSK 583, is a selective inhibitor of RIP-like interacting CLARP kinase RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines.

storage

Store at +4°C

References

1) Haile?et al.?(2016),?The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine; J. Med. Chem.,?59?4867 2) Goncharov?et al.?(2018),?Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling; Mol. Cell,?69?551

GSK583 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK583 Suppliers

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View Lastest Price from GSK583 manufacturers

Career Henan Chemical Co
Product
GSK583 1346547-00-9
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

1346547-00-9, GSK583Related Search:

BAY 11-7082 Phytosphingosine Andrographolide Oxaprozin RET Kinase inhibitor 1 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide GSK484 GSK369796 GSK461364 GSK547 GSK-467 GSK481 GSK-3326595 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide

  • GSK583
  • SK583
  • 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine
  • RIP2 kinase inhibitor 583
  • CS-2216
  • GSK583, >98%
  • GSK-583;GSK 583
  • 4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-
  • GSK583 >=98% (HPLC)
  • 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
  • GSK-583,GSK583,RIPK,Inhibitor,Receptor-interacting protein kinases,RIP kinase,GSK 583,inhibit
  • 1346547-00-9