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Remibrutinib

Product Name
Remibrutinib
CAS No.
1787294-07-8
Chemical Name
Remibrutinib
Synonyms
LOU064;LOU-064;REMIBRUTINIB;Lou064/Remibrutinib;Remibrutinib (LOU064);Remibrutinib, 10 mM in DMSO;Remibrutinib (LOU064) ，S9660;Btk,Inhibitor,inhibit,Remibrutinib,Bruton tyrosine kinase;N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide;N-(3-{5-[2-(Acryloyl-methyl-amino)-ethoxy]-6-amino-pyrimidin-4-yl}-5-fluoro-2-methyl-phenyl)-4-cyclopropyl-2-fluoro-benzamide
CBNumber
CB44675356
Molecular Formula
C27H27F2N5O3
Formula Weight
507.53
MOL File
1787294-07-8.mol
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Remibrutinib Property

Boiling point:
634.8±55.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 125 mg/mL (246.29 mM)
form 
Solid
pka
11.67±0.70(Predicted)
color 
White to off-white
InChIKey
CUABMPOJOBCXJI-UHFFFAOYSA-N
SMILES
C(NC1=CC(F)=CC(C2C(OCCN(C)C(=O)C=C)=C(N)N=CN=2)=C1C)(=O)C1=CC=C(C2CC2)C=C1F
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0103905
Product name
Remibrutinib
Purity
99.26%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0103905
Product name
Remibrutinib
Purity
99.26%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0103905
Product name
Remibrutinib
Purity
99.26%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0103905
Product name
Remibrutinib
Purity
99.26%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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Remibrutinib Chemical Properties,Usage,Production

Description

Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib has the potential for Chronic urticaria (CU) treatment.

Chemical Properties

White to off-white Solid

Uses

Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood[1]. Remibrutinib has the potential for Chronic urticaria (CU) treatment[2].

References

[1] Daniela Angst, et al. Novel amino pyrimidine derivatives. Patent WO2015079417A1.
[2] Kolkhir P, et al. New treatments for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23. DOI:10.1016/j.anai.2019.08.014

Remibrutinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Remibrutinib Suppliers

China 71 India 2 United States 3 Global 76
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
Shanghai XingMo Biotechnology Co., Ltd.
Tel
+86 13524779951; 13524779951
Fax
QQ: 2075692521
Email
2075692521@qq.com
Country
China
ProdList
298
Advantage
55
Bayee Biotech (Anqing) Co., Ltd.
Tel
0556-5032306 18917961636
Email
wtx@bayeebio.com
Country
China
ProdList
239
Advantage
61
Jinan XinKe Pharmaceutical Technology Co., Ltd.
Tel
18660188356
Fax
0531-88259693
Email
2820602043@qq.com
Country
China
ProdList
110
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2267
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
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View Lastest Price from Remibrutinib manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Remibrutinib 1787294-07-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-11-12
Zison Pharmaceutical (Shandong) Co., Ltd.
Product
Remibrutinib 1787294-07-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
＞98% by HPLC
Supply Ability
200kg/month
Release date
2025-10-10
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Remibrutinib 1787294-07-8
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2025-09-10

1787294-07-8, RemibrutinibRelated Search:


  • LOU064
  • LOU-064
  • REMIBRUTINIB
  • N-(3-{5-[2-(Acryloyl-methyl-amino)-ethoxy]-6-amino-pyrimidin-4-yl}-5-fluoro-2-methyl-phenyl)-4-cyclopropyl-2-fluoro-benzamide
  • Benzamide, N-[3-[6-amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluoro-
  • Remibrutinib (LOU064)
  • N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide
  • Btk,Inhibitor,inhibit,Remibrutinib,Bruton tyrosine kinase
  • N-[3-[6-Amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluorobenzamide
  • Remibrutinib, 10 mM in DMSO
  • Lou064/Remibrutinib
  • Remibrutinib (LOU064) ，S9660
  • 1787294-07-8
  • C27H27F2N5O3
  • chemical