dBET6

ChemicalBook > CAS DataBase List > dBET6

Product Name: dBET6
CAS No.: 1950634-92-0
Chemical Name: dBET6
Synonyms: dBET6;DBET6;DBET-6 ;DBET 6;dBET-6,Apoptosis,PROTACs,Inhibitor,inhibit,dBET6,Epigenetic Reader Domain,dBET 6;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide;(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-;2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02?]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]octyl]acetamide
CBNumber: CB44718444
Molecular Formula: C42H45ClN8O7S
Formula Weight: 841.37
MOL File: 1950634-92-0.mol

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dBET6 Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);71.32(Max Conc. mM)
Ethanol:35.0(Max Conc. mg/mL);41.6(Max Conc. mM)
form: A solid
pka: 10.68±0.40(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0047679
Product name: dBET6
Purity: 99.40%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0047679
Product name: dBET6
Purity: 99.40%
Packaging: 10mg
Price: $210
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BD177448
Product name: dBET6 NEW
Packaging: 25mg
Price: $292.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BD177448
Product name: dBET6 NEW
Packaging: 50mg
Price: $390
Updated: 2021/12/16

ChemScene

Product number: CS-0047679
Product name: dBET6
Purity: 99.40%
Packaging: 25mg
Price: $420
Updated: 2021/12/16

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dBET6 Chemical Properties,Usage,Production

Description

dBET6 is a potent, selective, and cell-permeable PROTAC connected by ligands for Cereblon and BET and has antitumor activity.

Definition

ChEBI: DBET6 is an organic molecular entity.

Biological Activity

dBET6 is a BET bromodomains PROTAC degrader with good cell permeability, binding to BRD4 with an IC50 of 14 nM. It also induces down-regulation and apoptosis of c-MYC.

target

Target	Value
BRD4 ()	14 nM

storage

Store at -20°C

dBET6 Preparation Products And Raw materials

Raw materials

Preparation Products

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dBET6 Suppliers

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1950634-92-0, dBET6Related Search:

dBET6

DBET6;DBET-6 ;DBET 6

(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-

2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide

dBET-6,Apoptosis,PROTACs,Inhibitor,inhibit,dBET6,Epigenetic Reader Domain,dBET 6

2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02?]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]octyl]acetamide

1950634-92-0

C42H45ClN8O7S