ChemicalBook > CAS DataBase List > dBET6
dBET6
- Product Name
- dBET6
- CAS No.
- 1950634-92-0
- Chemical Name
- dBET6
- Synonyms
- dBET6;DBET6;DBET-6 ;DBET 6;dBET-6,Apoptosis,PROTACs,Inhibitor,inhibit,dBET6,Epigenetic Reader Domain,dBET 6;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide;(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-;2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02?]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]octyl]acetamide
- CBNumber
- CB44718444
- Molecular Formula
- C42H45ClN8O7S
- Formula Weight
- 841.37
- MOL File
- 1950634-92-0.mol
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dBET6 Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:60.0(Max Conc. mg/mL);71.32(Max Conc. mM)
Ethanol:35.0(Max Conc. mg/mL);41.6(Max Conc. mM) - form
- A solid
- pka
- 10.68±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0047679
- Product name
- dBET6
- Purity
- 99.40%
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0047679
- Product name
- dBET6
- Purity
- 99.40%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- BD177448
- Product name
- dBET6 NEW
- Packaging
- 25mg
- Price
- $292.5
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- BD177448
- Product name
- dBET6 NEW
- Packaging
- 50mg
- Price
- $390
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0047679
- Product name
- dBET6
- Purity
- 99.40%
- Packaging
- 25mg
- Price
- $420
- Updated
- 2021/12/16
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dBET6 Chemical Properties,Usage,Production
Description
dBET6 is a potent, selective, and cell-permeable PROTAC connected by ligands for Cereblon and BET and has antitumor activity.
Definition
ChEBI: DBET6 is an organic molecular entity.
Biological Activity
dBET6 is a BET bromodomains PROTAC degrader with good cell permeability, binding to BRD4 with an IC50 of 14 nM. It also induces down-regulation and apoptosis of c-MYC.
target
| Target | Value |
| BRD4 () | 14 nM |
storage
Store at -20°C
dBET6 Preparation Products And Raw materials
Raw materials
Preparation Products
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