Jingzhaotoxin III
- Product Name
- Jingzhaotoxin III
- CAS No.
- 925463-91-8
- Chemical Name
- Jingzhaotoxin III
- Synonyms
- Jingzhaotoxin III
- CBNumber
- CB44718626
- Molecular Formula
- C174H241N47O46S6
- Formula Weight
- 0
- MOL File
- Mol file
Jingzhaotoxin III Property
- storage temp.
- Store at -20°C
- form
- Powder
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- Asp-Gly-Glu-Cys-Gly-Gly-Phe-Trp-Trp-Lys-Cys-Gly-Arg-Gly-Lys-Pro-Pro-Cys-Cys-Lys-Gly-Tyr-Ala-Cys-Ser-Lys-Thr-Trp-Gly-Trp-Cys-Ala-Val-Glu-Ala-Pro (Disulfide bridge: Cys4-Cys19; Cys11-Cys24; Cys18-Cys31)
N-Bromosuccinimide Price
- Product number
- 4913
- Product name
- JingzhaotoxinIII
- Packaging
- 100U
- Price
- $367
- Updated
- 2021/12/16
- Product number
- 255552
- Product name
- Jingzhaotoxin III
- Packaging
- 100ug
- Price
- $644
- Updated
- 2021/12/16
- Product number
- B5763
- Product name
- JingzhaotoxinIII
- Packaging
- 100ug
- Price
- $543
- Updated
- 2021/12/16
Jingzhaotoxin III Chemical Properties,Usage,Production
Description
Selective blocker of NaV5 channels (IC50 = 348 nM); displays no effect on other isoforms, including NaV2, NaV4, NaV6 and NaV7. Thought to inhibit sodium channel activation by binding to the NaV5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons.
Uses
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype[1][2].
storage
Store at -20°C
References
[1] Rong M, et, al. Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5. FASEB J. 2011 Sep; 25(9): 3177-85. DOI:10.1096/fj.10-178848
[2] Xiao Y, et, al. Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem. 2004 Jun 18; 279(25): 26220-6. DOI:10.1074/jbc.M401387200
Jingzhaotoxin III Preparation Products And Raw materials
Raw materials
Preparation Products
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