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2-Fluoro-4-(trifluoromethyl)aniline

Product Name
2-Fluoro-4-(trifluoromethyl)aniline
CAS No.
69409-98-9
Chemical Name
2-Fluoro-4-(trifluoromethyl)aniline
Synonyms
2-Fluoro-4-(trifluor;4-aMino-3-flurorbenzotrifluoride;4-AMINO-3-FLUOROBENZOTRIFLUORIDE;Aminofluorobenzotrifluoride 43---;2-fluoro-4-（trifluoromethyl）anline;2-FLUORO-4-(TRIFLUOROMETHYL)ANILINE;2-Fluoro-4-trifluoromethyl-phenylamine;BenzenaMine, 2-fluoro-4-(trifluoroMethyl)-;2-Fluoro-4-(trifluoromethyl)aniline, alpha,alpha,alpha,2-Tetrafluoro-p-toluidine
CBNumber
CB4475196
Molecular Formula
C7H5F4N
Formula Weight
179.11
MOL File
69409-98-9.mol
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2-Fluoro-4-(trifluoromethyl)aniline Property

Boiling point:
55 °C(Press: 0.3 Torr)
Density 
1.383±0.06 g/cm3(Predicted)
refractive index 
1.4650
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
liquid
pka
1.37±0.10(Predicted)
color 
Clear, faint yellow
CAS DataBase Reference
69409-98-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
RIDADR 
2810
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2921420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS003152
Product name
2-Fluoro-4-(trifluoromethyl)aniline
Purity
Aldrich<SUP>CPR</SUP>
Packaging
1 g
Price
$73.1
Updated
2025/07/31
TRC
Product number
B435265
Product name
2-Fluoro-4-(trifluoromethyl)aniline
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B435265
Product name
2-Fluoro-4-(trifluoromethyl)aniline
Packaging
100mg
Price
$60
Updated
2021/12/16
Oakwood
Product number
005809
Product name
2-Fluoro-4-(trifluoromethyl)aniline
Purity
99%
Packaging
250mg
Price
$19
Updated
2021/12/16
SynQuest Laboratories
Product number
3830-3-51
Product name
4-Amino-3-fluorobenzotrifluoride
Packaging
5G
Price
$32
Updated
2021/12/16
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2-Fluoro-4-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Synthesis

115029-24-8

69409-98-9

General procedure for the synthesis of 4-amino-3-fluorobenzotrifluoride from 2-fluoro-4-(trifluoromethyl)benzoic acid: 2-fluoro-4-(trifluoromethyl)benzoic acid (1 kg, 4.805 mol, 1.00 eq.) and CuCl (14.26 g, 0.144 mol, 0.03 eq.) were dissolved in 0-BuOH (11.7 L). Triethylamine (TEA, 533.8 g, 5.286 mol, 1.10 eq.) was added slowly and dropwise at room temperature. The reaction mixture was then heated to 50 °C and diphenylphosphoryl azide (DPPA, 1393 g, 5.045 mol, 1.05 eq.) was added slowly dropwise at 50-60 °C. The reaction mixture was heated at 80-85 °C overnight. After completion of the reaction, the solution was concentrated under reduced pressure. The residue was dissolved in water and filtered. The filtrate was extracted with ethyl acetate and the organic layer was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was dissolved in tert-butyl methyl ether (TBME) and HCl gas was passed into it for 2 hours. The filtrate was collected, dissolved in water and alkalized with 2M NaOH solution. The alkalized solution was extracted with TBME and the organic layer was dried and concentrated under reduced pressure to give 2-fluoro-4-(trifluoromethyl)aniline (498 g, 58% yield) as a red oil. The product was confirmed by 1H-NMR (300 MHz, CDCl3): δ 7.27 (m, 2H), 6.82 (m, 1H), 4.05 (bs, 2H); mass spectrum (MS): m/z = 180 [M + H]+.

References

[1] Patent: US2013/281710, 2013, A1. Location in patent: Paragraph 0268; 269; 270

2-Fluoro-4-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-(trifluoromethyl)aniline Suppliers

China 115 Europe 2 France 1 Germany 4 India 2 Italy 1 The Netherlands 1 United Kingdom 12 United States 24 Global 162
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
Email
jkinfo@jkchemical.com
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China
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96815
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Alfa Aesar
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400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
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China
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Ark Pharm, Inc.
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847-367-3680
Fax
847-367-3681
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sales@arkpharminc.com
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United States
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
Fax
86-027-87531808
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sales@chemwish.com
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China
ProdList
35896
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Capot Chemical Co., Ltd
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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18207
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Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
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+86-21-54098501
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+86-21-54096319
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sales@sinch.com.cn
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
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China
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11035
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Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
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View Lastest Price from 2-Fluoro-4-(trifluoromethyl)aniline manufacturers

Career Henan Chemical Co
Product
2-Fluoro-4-(trifluoromethyl)aniline 69409-98-9
Price
US $1.00/KG
Min. Order
100g
Purity
98%
Supply Ability
200KG
Release date
2019-12-17

69409-98-9, 2-Fluoro-4-(trifluoromethyl)anilineRelated Search:

2.3-DIFLUORO 4-TRIFLUOROMETHOXYANILINE 4-Amino-2,5-difluorobenzotrifluoride (6-CHLORO-2,3-DIFLUORO-4-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE 3-FLUORO-4-NITROBENZOTRIFLUORIDE 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE 2,3,5,6-TETRAFLUORO-4-AMINOBENZOTRIFLUORIDE 2-Fluoro-4-(trifluoromethyl)aniline 3-FLUORO-5-(TRIFLUOROMETHYL)ANILINE 5-FLUORO-2-(TRIFLUOROMETHYL)ANILINE 2-Amino-5-fluorobenzotrifluoride, 97% (4-Fluoro-2-(trifluoromethyl)aniline),4-FLUORO-2-(TRIFLUOROMETHYL)ANILINE 4-HYDROXY-8-BROMOQUINOLINE 2-BROMO-4-FLUORO-6-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-FLUORO-6-(TRIFLUOROMETHYL)ANILINE,4-Bromo-2-fluoro-6-(trifluoromethyl)aniline 99%,4-Bromo-2-fluoro-6-(trifluoromethyl)aniline99% 3,5-DIFLUORO-2-TRIFLUOROMETHYL-PHENYLAMINE 3-Amino-2-fluorobenzotrifluoride, 97% (2-Fluoro-3-(trifluoromethyl)aniline),2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE 98%,2-FLUORO-3-(TRIFLUOROMETHYL)ANILINE 3-FLUORO-4-(TRIFLUOROMETHYL)ANILINE 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE HYDROCHLORIDE 4-DIMETHYLAMINOHEPTAFLUOROTOLUENE

  • 2-FLUORO-4-(TRIFLUOROMETHYL)ANILINE
  • 4-AMINO-3-FLUOROBENZOTRIFLUORIDE
  • 2-fluoro-4-（trifluoromethyl）anline
  • Aminofluorobenzotrifluoride 43---
  • 2-Fluoro-4-(trifluor
  • BenzenaMine, 2-fluoro-4-(trifluoroMethyl)-
  • 4-aMino-3-flurorbenzotrifluoride
  • 2-Fluoro-4-(trifluoromethyl)aniline, alpha,alpha,alpha,2-Tetrafluoro-p-toluidine
  • 2-Fluoro-4-trifluoromethyl-phenylamine
  • 69409-98-9
  • 69409-98-8
  • Benzenes
  • Aromatic Halides (substituted)