ChemicalBook > CAS DataBase List > 2-Fluoro-4-(trifluoromethyl)aniline
2-Fluoro-4-(trifluoromethyl)aniline
- Product Name
- 2-Fluoro-4-(trifluoromethyl)aniline
- CAS No.
- 69409-98-9
- Chemical Name
- 2-Fluoro-4-(trifluoromethyl)aniline
- Synonyms
- 2-Fluoro-4-(trifluor;4-aMino-3-flurorbenzotrifluoride;4-AMINO-3-FLUOROBENZOTRIFLUORIDE;Aminofluorobenzotrifluoride 43---;2-fluoro-4-（trifluoromethyl）anline;2-FLUORO-4-(TRIFLUOROMETHYL)ANILINE;2-Fluoro-4-trifluoromethyl-phenylamine;BenzenaMine, 2-fluoro-4-(trifluoroMethyl)-;2-Fluoro-4-(trifluoromethyl)aniline, alpha,alpha,alpha,2-Tetrafluoro-p-toluidine
- CBNumber
- CB4475196
- Molecular Formula
- C7H5F4N
- Formula Weight
- 179.11
- MOL File
- 69409-98-9.mol
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2-Fluoro-4-(trifluoromethyl)aniline Property
- Boiling point:
- 55 °C(Press: 0.3 Torr)
- Density
- 1.383±0.06 g/cm3(Predicted)
- refractive index
- 1.4650
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- liquid
- pka
- 1.37±0.10(Predicted)
- color
- Clear, faint yellow
- CAS DataBase Reference
- 69409-98-9(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 2810
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2921420090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- CDS003152
- Product name
- 2-Fluoro-4-(trifluoromethyl)aniline
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $73.1
- Updated
- 2025/07/31
TRC
- Product number
- B435265
- Product name
- 2-Fluoro-4-(trifluoromethyl)aniline
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- B435265
- Product name
- 2-Fluoro-4-(trifluoromethyl)aniline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Oakwood
- Product number
- 005809
- Product name
- 2-Fluoro-4-(trifluoromethyl)aniline
- Purity
- 99%
- Packaging
- 250mg
- Price
- $19
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3830-3-51
- Product name
- 4-Amino-3-fluorobenzotrifluoride
- Packaging
- 5G
- Price
- $32
- Updated
- 2021/12/16
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2-Fluoro-4-(trifluoromethyl)aniline Chemical Properties,Usage,Production
Synthesis
115029-24-8
69409-98-9
General procedure for the synthesis of 4-amino-3-fluorobenzotrifluoride from 2-fluoro-4-(trifluoromethyl)benzoic acid: 2-fluoro-4-(trifluoromethyl)benzoic acid (1 kg, 4.805 mol, 1.00 eq.) and CuCl (14.26 g, 0.144 mol, 0.03 eq.) were dissolved in 0-BuOH (11.7 L). Triethylamine (TEA, 533.8 g, 5.286 mol, 1.10 eq.) was added slowly and dropwise at room temperature. The reaction mixture was then heated to 50 °C and diphenylphosphoryl azide (DPPA, 1393 g, 5.045 mol, 1.05 eq.) was added slowly dropwise at 50-60 °C. The reaction mixture was heated at 80-85 °C overnight. After completion of the reaction, the solution was concentrated under reduced pressure. The residue was dissolved in water and filtered. The filtrate was extracted with ethyl acetate and the organic layer was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was dissolved in tert-butyl methyl ether (TBME) and HCl gas was passed into it for 2 hours. The filtrate was collected, dissolved in water and alkalized with 2M NaOH solution. The alkalized solution was extracted with TBME and the organic layer was dried and concentrated under reduced pressure to give 2-fluoro-4-(trifluoromethyl)aniline (498 g, 58% yield) as a red oil. The product was confirmed by 1H-NMR (300 MHz, CDCl3): δ 7.27 (m, 2H), 6.82 (m, 1H), 4.05 (bs, 2H); mass spectrum (MS): m/z = 180 [M + H]+.
References
[1] Patent: US2013/281710, 2013, A1. Location in patent: Paragraph 0268; 269; 270
2-Fluoro-4-(trifluoromethyl)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-(trifluoromethyl)aniline manufacturers
Career Henan Chemical Co
- Product
- 2-Fluoro-4-(trifluoromethyl)aniline 69409-98-9
- Price
- US $1.00/KG
- Min. Order
- 100g
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2019-12-17
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