ChemicalBook > CAS DataBase List > CANDESARTAN-D4

CANDESARTAN-D4

Product Name
CANDESARTAN-D4
CAS No.
1346604-70-3
Chemical Name
CANDESARTAN-D4
Synonyms
CV-11974-d4;CANDESARTAN-D4;[2H4]-Candesartan;Candesartan M1-d4;Candesartan D4 (CV-11974 D4);2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1-(phenyl-d4)-1'-phenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid;1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid;1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid;2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)(2,3,5,6-2H?)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid;Candesartan D4Q: What is Candesartan D4 Q: What is the CAS Number of Candesartan D4 Q: What is the storage condition of Candesartan D4
CBNumber
CB4477701
Molecular Formula
C24H16D4N6O3
Formula Weight
444.48
MOL File
Mol file
More
Less

CANDESARTAN-D4 Property

Melting point:
151-157°C
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
color 
White to Off-White
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
25419
Product name
Candesartan-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
1mg
Price
$335
Updated
2024/03/01
Cayman Chemical
Product number
25419
Product name
Candesartan-d4
Purity
≥99% deuterated forms (d1-d4)
Packaging
5mg
Price
$669
Updated
2024/03/01
Usbiological
Product number
005550
Product name
Candesartan-d4
Packaging
1mg
Price
$531
Updated
2021/12/16
TRC
Product number
C175578
Product name
Candesartan-d4
Packaging
25mg
Price
$3630
Updated
2021/12/16
ChemScene
Product number
CS-4129
Product name
CandesartanD4
Purity
98.85%
Packaging
1mg
Price
$216
Updated
2021/12/16
More
Less

CANDESARTAN-D4 Chemical Properties,Usage,Production

Description

Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively) and an active metabolite of the prodrug candesartan cilexitil (Item No. 10489). It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg). Formulations containing candesartan have been used in the treatment of hypertension and heart failure.

Chemical Properties

CANDESARTAN-D4 is White to Off-White Solid

Uses

CANDESARTAN-D4 is an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

Uses

Labelled Candesartan, an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive.

References

[1] Y. INADA  S. C  T Nakane*. Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors[J]. Fundamental & Clinical Pharmacology, 2002, 16 4: 317-323. DOI: 10.1046/j.1472-8206.2002.00076.x
[2] Y SHIBOUTA. Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2’-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (+/-)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2’-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116).[J]. Journal of Pharmacology and Experimental Therapeutics, 1993, 266 1: 114-120.

CANDESARTAN-D4 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CANDESARTAN-D4 Suppliers

Canada 3 China 49 India 4 United States 9 Global 65
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Cato Research Chemicals Inc.
Tel
020-81960175
Fax
+1-541-2553641
Email
min.he@cato-chem.com
Country
China
ProdList
1955
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Artis Biotech Co. Ltd.
Tel
028-67271278 18628360895
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
1960
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-0755-28967200-8062 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9624
Advantage
60

1346604-70-3, CANDESARTAN-D4Related Search:

Octamethylcyclotetrasiloxane Candesartan

  • 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1-(phenyl-d4)-1'-phenyl]-4-yl]Methyl]-1H-benziMidazole-7-carboxylic Acid
  • Candesartan M1-d4
  • CV-11974-d4
  • CANDESARTAN-D4
  • [2H4]-Candesartan
  • Candesartan D4Q: What is Candesartan D4 Q: What is the CAS Number of Candesartan D4 Q: What is the storage condition of Candesartan D4
  • Candesartan D4 (CV-11974 D4)
  • 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
  • 2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)(2,3,5,6-2H?)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid
  • 1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid
  • 1346604-70-3
  • C24H16D4N6O3
  • Aromatics
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Isotope Labelled Compounds
  • Nucleotides
  • Pharmaceuticals