ChemicalBook > CAS DataBase List > AZ304

AZ304

Product Name: AZ304
CAS No.: 942507-42-8
Chemical Name: AZ304
Synonyms: AZ304;AZ304 ，S8755;AZ304;AZ-304;AZ 304;AZ304, 10 mM in DMSO;inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf;3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide;3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
CBNumber: CB44808617
Molecular Formula: C27H25N5O2
Formula Weight: 451.52
MOL File: 942507-42-8.mol

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AZ304 Property

Boiling point:: 582.6±50.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 12.87±0.70(Predicted)
color: White to off-white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0064828
Product name: AZ304
Purity: 99.39%
Packaging: 25mg
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: BISN0220
Product name: 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
Packaging: 5mg
Price: $160
Updated: 2021/12/16

ChemScene

Product number: CS-0064828
Product name: AZ304
Purity: 99.39%
Packaging: 50mg
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: BISN0220
Product name: 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
Packaging: 10mg
Price: $261
Updated: 2021/12/16

ChemScene

Product number: CS-0064828
Product name: AZ304
Purity: 99.39%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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AZ304 Chemical Properties,Usage,Production

Uses

AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.

Biological Activity

AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.

in vitro

AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.

in vivo

In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> BRAF(V600E)
(Cell-free assay) < /tr>

Target	Value
p38 (Cell-free assay)	6 nM
CSF1R (Cell-free assay)	35 nM
38 nM
CRAF (Cell-free assay )	68 nM
WT BRAF (Cell-free assay)	79 nM

IC 50

BRaf^V600E: 38 nM (IC₅₀); BRAF^WT: 79 nM (IC₅₀); CRAF: 68 nM (IC₅₀); p38: 6 nM (IC₅₀); CSF1R: 35 nM (IC₅₀); MAP3K7: 6400 nM (IC₅₀); CSK: 7050 nM (IC₅₀)

AZ304 Preparation Products And Raw materials

Raw materials

Preparation Products

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942507-42-8, AZ304Related Search:

AZ304;AZ-304;AZ 304

AZ304

Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-

3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide

3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide

inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf

AZ304, 10 mM in DMSO

AZ304 ，S8755

942507-42-8

API