AZ304
- Product Name
- AZ304
- CAS No.
- 942507-42-8
- Chemical Name
- AZ304
- Synonyms
- AZ304;AZ304;AZ-304;AZ 304;inhibit,AZ 304,Raf kinases,Autophagy,AZ304,Inhibitor,AZ-304,Raf;3-(2-Cyano-2-propanyl)-N-{3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl}benzamide;3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(7-methoxy-4-quinazolinyl)amino]-4-methylphenyl]-
- CBNumber
- CB44808617
- Molecular Formula
- C27H25N5O2
- Formula Weight
- 451.52
- MOL File
- 942507-42-8.mol
AZ304 Property
- Boiling point:
- 582.6±50.0 °C(Predicted)
- Density
- 1.270±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 12.87±0.70(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0064828
- Product name
- AZ304
- Purity
- 99.39%
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- BISN0220
- Product name
- 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
- Packaging
- 5mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CS-0064828
- Product name
- AZ304
- Purity
- 99.39%
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- BISN0220
- Product name
- 3-(2-Cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide
- Packaging
- 10mg
- Price
- $261
- Updated
- 2021/12/16
- Product number
- CS-0064828
- Product name
- AZ304
- Purity
- 99.39%
- Packaging
- 100mg
- Price
- $450
- Updated
- 2021/12/16
AZ304 Chemical Properties,Usage,Production
Uses
AZ304 is potent dual BRAF inhibitor. Is a combination of MEK and B-raf inhibitors for treatment of cancer.
Biological Activity
AZ304 is a synthetic inhibitor targeting wild-type and V600E mutant BRAF with IC50 of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R with IC50 below 100 nM.
in vitro
AZ304 inhibited wild-type BRAF and CRAF, BRAF in vitro.
in vivo
In both RKO and Caco-2 tumor models, administration of AZ304 alone or in combination with Cetuximab resulted in antitumor activity without apparent toxic effects (regardless of BRAF mutation).
target
| Target | Value |
| p38 (Cell-free assay) | 6 nM |
| CSF1R (Cell-free assay) | 35 nM |
| 38 nM | |
| CRAF (Cell-free assay ) | 68 nM |
| WT BRAF (Cell-free assay) | 79 nM | < /tr>