CHRYSOERIOL Property

Melting point:

>300°C (dec.)

Boiling point:

574.3±50.0 °C(Predicted)

Density 

1.512±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly, Heated and Sonicated)

form 

Solid

pka

6.49±0.40(Predicted)

color 

Yellow to Very Dark Yellow

Stability:

Hygroscopic

LogP

2.229 (est)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

CHRYSOERIOL Chemical Properties,Usage,Production

Uses

Chrysoeriol is a methoxyflavonoid that selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. A metabolite of Luteolin (L475000).

Definition

ChEBI: The 3'-O-methyl derivative of luteolin.

target

ERK | p38 | Akt | PI3K | mTOR | p21 | AhR | P450 (e.g. CYP17) | NOS | NF-kB | AP-1 | ROS | Potassium Channel