ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE
- Product Name
- ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE
- CAS No.
- 348-36-7
- Chemical Name
- ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE
- Synonyms
- 5-F-ICA-OEt;Ethyl 5-fluoroindole;2-CARBETHOXY-5-FLUOROINDOLE;2-ETHYLFORMATE-5-FLUOROINDOLE;Ethyl 5- fluoroindole -2- formate;ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE;ETHYL 5-FLUORO-1H-INDOLE-2-CARBOXYLATE;Ethyl 5-fluoroindole-2-carboxylate 96%;5-Fluoro-2-indolecarboxylic acid ethyl;5-Fluoroindole-2-carboxylic acid ethyl este
- CBNumber
- CB4481106
- Molecular Formula
- C11H10FNO2
- Formula Weight
- 207.2
- MOL File
- 348-36-7.mol
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE Property
- Melting point:
- 146-150 °C
- Boiling point:
- 345.9±22.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 14.17±0.30(Predicted)
- color
- White to Yellow to Orange
- λmax
- 281nm(EtOH)(lit.)
- BRN
- 170254
- InChIKey
- VIKOQTQMWBKMNA-UHFFFAOYSA-N
- CAS DataBase Reference
- 348-36-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 579858
- Product name
- Ethyl 5-fluoroindole-2-carboxylate
- Purity
- 96%
- Packaging
- 5g
- Price
- $88.3
- Updated
- 2025/07/31
- Product number
- E1035
- Product name
- Ethyl 5-Fluoroindole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $134
- Updated
- 2025/07/31
- Product number
- E1035
- Product name
- Ethyl 5-Fluoroindole-2-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $403
- Updated
- 2025/07/31
- Product number
- E918345
- Product name
- Ethyl5-Fluoro-1H-indole-2-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- V1767
- Product name
- Ethyl 5-Fluoroindole-2-carboxylate
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
light yellow powder
Uses
- Reactant for preparation of antitumor agents
- Reactant for preparation of antihyperlipidemic agents
- Reactant for preparation of factor Xa inhibitors
- Reactant for preparation of potential antiarrhythmic agents
- Reactant for preparation of inhibitors of the cytosolic phospholipase A2
- Reactant for preparation of thromboxane receptor antagonist and thromboxane synthase inhibitor via Mitsunobu reaction
Uses
Reactant for preparation of antitumor agents 1 Reactant for preparation of antihyperlipidemic agents 2 Reactant for preparation of factor Xa inhibitors 3 Reactant for preparation of potential antiarrhythmic agents 4 Reactant for preparation of inhibitors of the cytosolic phospholipase A2 5 Reactant for preparation of thromboxane receptor antagonist and thromboxane synthase inhibitor via Mitsunobu reaction 6
Synthesis
351-64-4
348-36-7
Phenylhydrazone 4-fluorophenylhydrazine pyruvate (65 g) was used as a raw material, which was added to a mixture of polyphosphoric acid (500 g) and phosphoric acid (250 g) that had been pre-mixed and heated to 75°C. The reaction was carried out by stirring for 1 hour. The reaction was stirred at a temperature range of 75-85°C for 1 hour to ensure complete reaction of the feedstock. Subsequently, the reaction was continued at the same temperature conditions for 20 minutes and the completion of the reaction was confirmed by monitoring. The reaction mixture was slowly poured into an ice-water mixture (1500 g) and cooled to room temperature. The resulting light yellow solid was separated and dried to give the final ethyl 5-fluoroindole-2-carboxylate (52.2 g) in 87% yield.
References
[1] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0040; 0042
[2] Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1954, vol. 297, p. 229,233
[3] Journal of the Chemical Society, 1955, p. 1283,1284
[4] Archiv der Pharmazie, 2008, vol. 341, # 5, p. 294 - 300
[5] European Journal of Medicinal Chemistry, 2013, vol. 69, p. 125 - 138
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE Suppliers
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- Switzerland
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View Lastest Price from ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE manufacturers
- Product
- ethyl 5-fluoroindole-2-carboxylate 348-36-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- ETHYL 5-FLUOROINDOLE-2-CARBOXYLATE 348-36-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11