Ethyl 6-fluoroindole-2-carboxylate
- Product Name
- Ethyl 6-fluoroindole-2-carboxylate
- CAS No.
- 348-37-8
- Chemical Name
- Ethyl 6-fluoroindole-2-carboxylate
- Synonyms
- Piperazine,4-(methylsulfonyl)-;ETHYL 6-FLUOROINDOLE-2-CARBOXYLATE;Ethyl 6-fluoro-1H-indol-2-carboxylate;2-(Ethoxycarbonyl)-6-fluoro-1H-indole;6-FLUOROINDOLE-2-CARBOXYLIC ACID ETHYL ESTER;1H-Indole-2-carboxylic acid, 6-fluoro-, ethyl ester;6-Fluoro-1H-indole-2-carboxylic acid ethyl ester, 98%;6-fluoro-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI);1H-Indole-2-carboxylic acid, 6-fluoro-, ethyl ester (9CI, ACI)
- CBNumber
- CB5769115
- Molecular Formula
- C11H10FNO2
- Formula Weight
- 207.2
- MOL File
- 348-37-8.mol
Ethyl 6-fluoroindole-2-carboxylate Property
- Melting point:
- 143 °C
- Boiling point:
- 345.9±22.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.41±0.30(Predicted)
- form
- solid
- color
- Light yellow
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 348-37-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- PHB00185
- Product name
- Ethyl 6-fluoro-1H-indole-2-carboxylate
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $87.5
- Updated
- 2025/07/31
- Product number
- E918358
- Product name
- Ethyl6-Fluoro-1H-indole-2-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC3029
- Product name
- Ethyl6-fluoro-1H-indole-2-carboxylate
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 4H23-3-X3
- Product name
- Ethyl 6-fluoroindole-2-carboxylate
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 210636
- Product name
- Ethyl6-fluoro-1H-indole-2-carboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $108
- Updated
- 2021/12/16
Ethyl 6-fluoroindole-2-carboxylate Chemical Properties,Usage,Production
Synthesis
346-43-0
348-37-8
(3-2) Ethyl 3-(4-fluoro-2-nitrophenyl)-2-oxopropanoate (5.51 g, 21.6 mmol) obtained in Reference Example (3-1) was dissolved in a mixed solvent of ethanol and acetic acid (1:1, 84 mL, by volume). Iron powder (10.9 g, 144 mmol) was added to this solution and the mixture was subsequently heated to reflux for 3.5 hours. Upon completion of the reaction, the reaction mixture was diluted with tetrahydrofuran and filtered through diatomaceous earth to remove insoluble material. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/acetone = 15:1) to afford ethyl 6-fluoro-1H-indole-2-carboxylate (3.62 g, 81% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 8.89 (1H, br.s), 7.61 (1H, dd, J=8.8,5.5 Hz), 7.20 (1H, m), 7.09 (1H, dd, J=9.4,2.0 Hz), 6.94 (1H, dd, J=9.4,8.8,2.0 Hz). 4.41 (2H, q, J=7.0 Hz), 1.42 (3H, t, J=7.0 Hz). (9-6) Ethyl 3-(4-fluoro-2-nitrophenyl)-2-oxopropanoate (5.51 g, 21.6 mmol) obtained in Reference Example (9-5) was dissolved in a mixed solvent of ethanol and acetic acid (1:1, 84 mL, by volume). Iron powder (10.9 g, 144 mmol) was added to this solution and the mixture was subsequently heated to reflux for 3.5 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and diluted with tetrahydrofuran. Insoluble material was removed by filtration through diatomaceous earth and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: dichloromethane/acetone=15:1) to afford ethyl 6-fluoro-1H-indole-2-carboxylate (3.62 g, 81% yield) as yellow crystalline. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 8.89 (1H, br.s), 7.61 (1H, dd, J=8.8,5.5 Hz), 7.20 (1H, m), 7.09 (1H, dd, J=9.4,2.0 Hz), 6.94 (1H, dd, J=9.4,8.8,2.0 Hz). 4.41 (2H, q, J=7.0Hz), 1.42 (3H, t, J=7.0Hz).
References
[1] Patent: EP1764075, 2007, A1. Location in patent: Page/Page column 81-82; 91
[2] Patent: WO2006/109633, 2006, A1. Location in patent: Page/Page column 138-139
Ethyl 6-fluoroindole-2-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from Ethyl 6-fluoroindole-2-carboxylate manufacturers
- Product
- Ethyl 6-fluoroindole-2-carboxylate 348-37-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-02