6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID

Product Name: 6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID
CAS No.: 23077-44-3
Chemical Name: 6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID
Synonyms: OTAVA-BB 1149596;RARECHEM AL BE 0955;UKRORGSYN-BB BBV-5127372;6-Fluoro-indole-3-carboxylic acid;Indole-3-carboxylic acid, 6-fluoro-;6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylic acid, 6-fluoro-
CBNumber: CB5197848
Molecular Formula: C9H6FNO2
Formula Weight: 179.15
MOL File: 23077-44-3.mol

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6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID Property

Melting point:: 242-244 °C (decomp)
Boiling point:: 422.2±25.0 °C(Predicted)
Density: 1.510±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 3.73±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

RIDADR: UN2811
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F600538
Product name: 6-Fluoro-1H-indole-3-carboxylicacid
Packaging: 25mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 7848AD
Product name: 6-Fluoroindole-3-carboxylicacid
Packaging: 100mg
Price: $122
Updated: 2021/12/16

Apolloscientific

Product number: PC906871
Product name: 6-Fluoro-1H-indole-3-carboxylicacid
Purity: 98%
Packaging: 250mg
Price: $143
Updated: 2021/12/16

Matrix Scientific

Product number: 089646
Product name: 6-Fluoroindole-3-carboxylic acid
Packaging: 250mg
Price: $158
Updated: 2021/12/16

Matrix Scientific

Product number: 089646
Product name: 6-Fluoroindole-3-carboxylic acid
Packaging: 1g
Price: $395
Updated: 2021/12/16

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6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Synthesis

399-51-9

407-25-0

23077-44-3

Trifluoroacetic anhydride (9.009 mL, 64.8 mmol, 2.2 eq.) was added slowly and dropwise to a stirred solution of 6-fluoroindole (4.000 g, 29.6 mmol, 1.0 eq.) dissolved in DMF (25 mL) at 0 °C (temperature controlled using an external ice bath). After the reaction mixture was kept in the ice bath for 3 h, the reaction was quenched with 40 mL of 2N sodium carbonate solution. The precipitate was collected by filtration and washed with distilled water. The resulting solid was dissolved in 4 M NaOH solution (50 mL) and refluxed for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and poured into 50 mL of distilled water. The mixture was cooled again in an ice bath and the pH was adjusted slowly by adding 6N HCl to 3. The precipitate precipitated was collected by filtration, washed with distilled water and dried under vacuum to give the off-white solid product 6-fluoro-1H-indole-3-carboxylic acid (3.5 g, 66% yield).

References

[1] Patent: WO2017/197177, 2017, A1. Location in patent: Paragraph 0219-0221
[2] ChemMedChem, 2012, vol. 7, # 11, p. 1915 - 1920

6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID Suppliers

China 59 Germany 1 India 2 United Kingdom 1 United States 7 Global 70

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View Lastest Price from 6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID 23077-44-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

23077-44-3, 6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACIDRelated Search:

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6-FLUORO-1H-INDOLE-3-CARBOXYLIC ACID

RARECHEM AL BE 0955

Indole-3-carboxylic acid, 6-fluoro-

OTAVA-BB 1149596

UKRORGSYN-BB BBV-5127372

6-Fluoro-indole-3-carboxylic acid

1H-Indole-3-carboxylic acid, 6-fluoro-

23077-44-3

pharmacetical