6-FLUOROINDOLE-3-CARBOXALDEHYDE
- Product Name
- 6-FLUOROINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 2795-41-7
- Chemical Name
- 6-FLUOROINDOLE-3-CARBOXALDEHYDE
- Synonyms
- 6-FLUOROINDOLE-3-ALDEHYDE;6-Fluoro-3-formyl-1H-indole;1H6-FLUOROINDOLE-3-ALDEHYDE;6-FLUOROINDOLE-3-CARBALDEHYDE;6-FLUOROINDOLE-3-CARBOXALDEHYDE;6-fluoro-1H-indole-3-carbaldehyde;1H-6-FLUOROINDOLE-3-CARBOXALDEHYDE;6-Fluoro-1H-indole-3-carboxaldehyde;6-Fluoroindole-3-carboxaldehyde,98%;6-Fluoroindole-3-carboxaldehyde ,97%
- CBNumber
- CB9305232
- Molecular Formula
- C9H6FNO
- Formula Weight
- 163.15
- MOL File
- 2795-41-7.mol
6-FLUOROINDOLE-3-CARBOXALDEHYDE Property
- Melting point:
- 174-178°C
- Boiling point:
- 342.4±22.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in methanol.
- form
- crystalline
- pka
- 14.90±0.30(Predicted)
- color
- yellow
- CAS DataBase Reference
- 2795-41-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F592298
- Product name
- 6-Fluoroindole-3-carboxaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H15-3-63
- Product name
- 1H-6-Fluoroindole-3-carboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- JK366453
- Product name
- 6-Fluoroindole-3-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- 075226
- Product name
- 6-Fluoroindole-3-carboxaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 4H15-3-63
- Product name
- 1H-6-Fluoroindole-3-carboxaldehyde
- Purity
- 98%
- Packaging
- 5G
- Price
- $95
- Updated
- 2021/12/16
6-FLUOROINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Yellow crystal
Uses
6-Fluoroindole-3-carboxaldehyde is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.
Synthesis
399-51-9
68-12-2
2795-41-7
GENERAL STEPS: Oxalyl chloride (0.3 mL) was slowly added dropwise to cooled (ice bath) N,N-dimethylformamide (3 mL) under stirring conditions. The reaction mixture was stirred continuously at 0 °C for 1 hour. Subsequently, 6-fluoroindole (4 mmol) was dissolved in N,N-dimethylformamide (1.5 mL) and the resulting solution was added slowly dropwise to the above reaction mixture. The reaction system was stirred at room temperature for 5 hours. Upon completion of the reaction, 2 N sodium hydroxide solution (2 mL) was added and the mixture was heated to 100 °C and held for 10 minutes. The reaction solution was cooled and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with water and saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography with the eluent of ethyl acetate/petroleum ether (3:1, v/v) to obtain pure 6-fluoroindole-3-carbaldehyde.
References
[1] Journal of the American Chemical Society, 2009, vol. 131, # 31, p. 10796 - 10797
[2] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 158 - 167
[3] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 10, p. 3307 - 3312
[4] Journal of Enzyme Inhibition and Medicinal Chemistry, 2011, vol. 26, # 2, p. 261 - 269
[5] Patent: CN103664895, 2018, B. Location in patent: Paragraph 0124-0126
6-FLUOROINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-FLUOROINDOLE-3-CARBOXALDEHYDE manufacturers
- Product
- 6-Fluoroindole-3-carboxaldehyde in stock Factory 2795-41-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
- Product
- 6-FLUOROINDOLE-3-CARBOXALDEHYDE 2795-41-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-07