5-FLUOROINDOLE-3-CARBOXALDEHYDE
- Product Name
- 5-FLUOROINDOLE-3-CARBOXALDEHYDE
- CAS No.
- 2338-71-8
- Chemical Name
- 5-FLUOROINDOLE-3-CARBOXALDEHYDE
- Synonyms
- 120351;AKOS JY2083653;TIMTEC-BB SBB002930;5-Fluoro-3-formylindole;5-FLUOROINDOLE-3-ALDEHYDE;5-Fluoro-3-formyl-1H-indole;5-FLUOROINDOLE-3-CARBALDEHYDE;5-Fluoro-3-indolecarboxaldehyde;5-FLUOROINDOLE-3-CARBOXALDEHYDE;5-FLUORO-1H-INDOLE-3-CARBALDEHYDE
- CBNumber
- CB9393765
- Molecular Formula
- C9H6FNO
- Formula Weight
- 163.15
- MOL File
- 2338-71-8.mol
5-FLUOROINDOLE-3-CARBOXALDEHYDE Property
- Melting point:
- 164°C
- Boiling point:
- 342.4±22.0 °C(Predicted)
- Density
- 1.385±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- crystalline
- pka
- 14.66±0.30(Predicted)
- color
- yellow to green
- Sensitive
- Air Sensitive
- BRN
- 1449216
- CAS DataBase Reference
- 2338-71-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F2001
- Product name
- 5-Fluoroindole-3-carboxaldehyde
- Purity
- ≥99%, crystalline
- Packaging
- 1g
- Price
- $423
- Updated
- 2023/06/20
- Product number
- F485795
- Product name
- 5-Fluoroindole-3-carboxaldehyde
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC9638
- Product name
- 5-Fluoro-1H-indole-3-carboxaldehyde
- Packaging
- 1g
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 4H15-3-Y4
- Product name
- 5-Fluoroindole-3-carboxaldehyde
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- PC9638
- Product name
- 5-Fluoro-1H-indole-3-carboxaldehyde
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
5-FLUOROINDOLE-3-CARBOXALDEHYDE Chemical Properties,Usage,Production
Uses
5-Fluoroindole-3-carboxaldehyde is used as a reagent in the synthetic preparation of compounds requiring an indole group or more specifically a fluoroindole group.
Synthesis
399-52-0
68-12-2
2338-71-8
GENERAL METHOD: Phosphoryl chloride (0.42 g, 2.74 mmol) was slowly added dropwise to a solution of N,N-dimethylformamide (0.84 g, 11.4 mmol) of 5-fluoroindole (0.30 g, 2.29 mmol) at 0 °C, the dropwise process lasted for 30 min. Subsequently, the reaction mixture was warmed up to 40 °C and kept for 1 hour. Upon completion of the reaction, ice was added to the reaction vessel followed by 2 M sodium hydroxide solution. The mixture was refluxed for 40 minutes. After the reaction solution was cooled to room temperature, it was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent being a mixed solvent of petroleum ether-ethyl acetate to give the target compound 5-fluoroindole-3-carboxaldehyde [19].
References
[1] Archiv der Pharmazie, 2017, vol. 350, # 1,
[2] Journal of the American Chemical Society, 2009, vol. 131, # 31, p. 10796 - 10797
[3] Marine Drugs, 2014, vol. 12, # 4, p. 1757 - 1772
[4] Patent: WO2015/90233, 2015, A1. Location in patent: Paragraph 00263
[5] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 344 - 367
5-FLUOROINDOLE-3-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-FLUOROINDOLE-3-CARBOXALDEHYDE manufacturers
- Product
- 5-Fluoroindole-3-carboxaldehyde in stock Factory 2338-71-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
- Product
- 5-Methoxyindole-3-cabroxaldehyde in stock Factory 2338-71-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- TOP 3 Factory in China
- Supply Ability
- Top 3 largest production capacity Factory
- Release date
- 2019-04-03
- Product
- 5-FLUOROINDOLE-3-CARBOXALDEHYDE 2338-71-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-01-08