3-MORPHOLIN-4-YL-PROPIONIC ACID
- Product Name
- 3-MORPHOLIN-4-YL-PROPIONIC ACID
- CAS No.
- 4497-04-5
- Chemical Name
- 3-MORPHOLIN-4-YL-PROPIONIC ACID
- Synonyms
- AKOS BB-5602;AKOS BBS-00002594;BUTTPARK 145\04-88;CHEMBRDG-BB 4010141;RARECHEM AL BO 1512;TIMTEC-BB SBB010411;4-MORPHOLINEPROPIONIC ACID;4-MORPHOLINEPROPANOIC ACID;3-Morpholin-4-yl-propionicaci;3-MORPHOLIN-4-YLPROPANOIC ACID
- CBNumber
- CB4483539
- Molecular Formula
- C7H13NO3
- Formula Weight
- 159.18
- MOL File
- 4497-04-5.mol
3-MORPHOLIN-4-YL-PROPIONIC ACID Property
- Melting point:
- 74-76 °C
- Boiling point:
- 174-176 °C(Press: 2 Torr)
- Density
- 1.159±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 3.74±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H13NO3/c9-7(10)1-2-8-3-5-11-6-4-8/h1-6H2,(H,9,10)
- InChIKey
- YUYHRSGXZZVNMS-UHFFFAOYSA-N
- SMILES
- N1(CCC(O)=O)CCOCC1
- CAS DataBase Reference
- 4497-04-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- X3841
- Product name
- 3-Morpholin-4-ylpropanoicacid
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- 4H21-9-32
- Product name
- 3-Morpholinopropanoic acid hydrobromide
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 019572
- Product name
- 3-Morpholin-4-yl-propionic acid
- Packaging
- 500mg
- Price
- $182
- Updated
- 2021/12/16
- Product number
- CHM0023908
- Product name
- 3-MORPHOLINOPROPANOIC ACID
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $770
- Updated
- 2021/12/16
- Product number
- CHM0023908
- Product name
- 3-MORPHOLINOPROPANOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $866.25
- Updated
- 2021/12/16
3-MORPHOLIN-4-YL-PROPIONIC ACID Chemical Properties,Usage,Production
Synthesis
33611-43-7
4497-04-5
The general procedure for the synthesis of 3-(4-morpholino)propionic acid from methyl 3-morpholino propionate was as follows: potassium hydroxide (485 mg, 8.6 mmol) was added to a solution of methyl 3-morpholino propionate (1 g, 5.7 mmol) in ethanol (20 mL) and the mixture was stirred for 2 hr at 80°C. The reaction was carried out using the same method as that used for the synthesis of methyl 3-morpholino propionate. Upon completion of the reaction, the solution was allowed to cool to room temperature and the pH was adjusted to 1 with 6 M hydrochloric acid. insoluble material was removed by filtration, and the volatiles in the filtrate were subsequently removed by evaporation. The resulting oil was ground with ether, the solid product was collected by filtration, washed with dichloromethane and dried under vacuum to give 3-morpholino propionic acid (993 mg, 89% yield) as a white solid. The structure of the product was confirmed by 1H NMR spectroscopy (DMSO-d6; CF3COOD): δ 2.83 (t, 2H), 3.13 (t, 2H), 3.36 (t, 2H), 3.46 (d, 2H), 3.73 (t, 2H), 3.97 (d, 2H). Mass spectrometry analysis (MS-ESI) showed a molecular ion peak of 159 [MH]+.
References
[1] Patent: US6184225, 2001, B2
[2] Journal of Medicinal Chemistry, 1993, vol. 36, # 3, p. 320 - 330
[3] Patent: US2008/9491, 2008, A1. Location in patent: Page/Page column 15
[4] RSC Advances, 2017, vol. 7, # 75, p. 47297 - 47308
3-MORPHOLIN-4-YL-PROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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