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FEN1-IN-1

Product Name
FEN1-IN-1
CAS No.
824983-91-7
Chemical Name
FEN1-IN-1
Synonyms
LNT 1;FEN1-IN-1;FEN1 inhibitor 1;EN1 Inhibitor C1;LNT 1 (FEN1-IN-1);FEN1-IN-1, 10 mM in DMSO;FEN1 IN 1,FEN-1-IN-1,inhibit,Inhibitor,FEN1IN1;1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione;1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione;Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-
CBNumber
CB44844767
Molecular Formula
C15H12N2O5S
Formula Weight
332.33
MOL File
824983-91-7.mol
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FEN1-IN-1 Property

Boiling point:
548.9±52.0 °C(Predicted)
Density 
1.583±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in DMSO (15 mg/ml)
pka
7.91±0.20(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris
Product number
6510
Product name
LNT1
Purity
≥98%(HPLC)
Packaging
5
Price
$197
Updated
2021/12/16
Axon Medchem
Product number
Axon3027
Product name
FEN1inhibitor1-LNT1
Purity
99%
Packaging
25mg
Price
$522.5
Updated
2021/12/16
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FEN1-IN-1 Chemical Properties,Usage,Production

Description

LNT 1 (824983-91-7) is a potent (IC50 = 11 nM) inhibitor of flap endonuclease 1 (FEN1).1 It showed similar potency in inhibiting exonuclease 1 (EXO1).2 Induces a DNA damage response and ultimately cell death. FEN1 inhibitors have therapeutic potential for the treatment of cancers that are defective for homologous repair and other DNA repair and DNA damage checkpoint pathways.4

storage

Store at -20°C

References

[1] L. NATHAN TUMEY. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2005, 15 2: Pages 277-281. DOI:10.1016/j.bmcl.2004.10.086
[2] JACK C EXELL. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site[J]. Nature chemical biology, 2016, 12 10: 815-821. DOI:10.1038/nchembio.2148
[3] THOMAS A WARD  Stephen T D  Peter J McHugh. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.[J]. PLoS ONE, 2017: e0179278. DOI:10.1371/journal.pone.0179278
[4] ELAINE GUO. FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2020: 19415-19424. DOI:10.1073/pnas.2009237117

FEN1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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FEN1-IN-1 Suppliers

China 36 United States 5 Global 41
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-846993838003-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
3249
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2391
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10083
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58

824983-91-7, FEN1-IN-1Related Search:

Tigecycline Levetiracetam AZ20 Dequalinium chloride

  • FEN1-IN-1
  • EN1 Inhibitor C1
  • 1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
  • LNT 1 (FEN1-IN-1)
  • LNT 1
  • Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione, 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-
  • 1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
  • FEN1 inhibitor 1
  • FEN1 IN 1,FEN-1-IN-1,inhibit,Inhibitor,FEN1IN1
  • 1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-3-hydroxy-1H,2H,3H,4H-thieno[3,2-d]pyrimidine-2,4-dione
  • FEN1-IN-1, 10 mM in DMSO
  • 824983-91-7