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DBCO-PEG5-NHS ester

Product Name
DBCO-PEG5-NHS ester
CAS No.
2144395-59-3
Chemical Name
DBCO-PEG5-NHS ester
Synonyms
4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber
CB44849429
Molecular Formula
C36H43N3O11
Formula Weight
693.74
MOL File
2144395-59-3.mol
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DBCO-PEG5-NHS ester Property

solubility 
Soluble in DMSO, DCM, DMF
form 
Oil
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-24055
Product name
DBCO-PEG5-NHSester
Purity
96%
Packaging
25mg
Price
$170
Updated
2021/12/16
BroadPharm
Product number
BP-24055
Product name
DBCO-PEG5-NHSester
Purity
96%
Packaging
100mg
Price
$480
Updated
2021/12/16
BroadPharm
Product number
BP-24055
Product name
DBCO-PEG5-NHSester
Purity
96%
Packaging
500mg
Price
$1650
Updated
2021/12/16
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DBCO-PEG5-NHS ester Chemical Properties,Usage,Production

Description

DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.

Biological Activity

DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

Alkyl/ether

PEGs

DBCO-PEG5-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-PEG5-NHS ester Suppliers

Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
021-58088081 Q3382968513
Fax
QQ3382968513
Email
hailey@shsendpharm.com
Country
China
ProdList
3129
Advantage
55
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-0431-80514535 19917294565
Email
et@chemextension.com
Country
China
ProdList
3987
Advantage
55
Borenpharm Co., Ltd
Tel
027-65563561
Fax
86-27-59218822
Email
sales@borenpharm.com
Country
China
ProdList
1245
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4824
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
Tel
029-86217788 13892832556
Email
2440688701@qq.com
Country
China
ProdList
1991
Advantage
58
Shaanxi borno biotechnology co., LTD
Tel
+86-13759708231
Email
asherw9@hotmail.com
Country
China
ProdList
2350
Advantage
58
Hangzhou Taorui Biotechnology Co., Ltd
Tel
4000-360-990 15268198094
Email
sales@torreybio.com
Country
China
ProdList
2862
Advantage
58
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View Lastest Price from DBCO-PEG5-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-PEG5-NHS ester 2144395-59-3
Price
US $0.00/mg
Min. Order
50mg
Purity
>99.00%
Supply Ability
250mg
Release date
2024-03-20

2144395-59-3, DBCO-PEG5-NHS esterRelated Search:


  • 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • 2144395-59-3
  • C36H43N3O11