DBCO-PEG5-NHS ester
- Product Name
- DBCO-PEG5-NHS ester
- CAS No.
- 2144395-59-3
- Chemical Name
- DBCO-PEG5-NHS ester
- Synonyms
- 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB44849429
- Molecular Formula
- C36H43N3O11
- Formula Weight
- 693.74
- MOL File
- 2144395-59-3.mol
DBCO-PEG5-NHS ester Property
- solubility
- Soluble in DMSO, DCM, DMF
N-Bromosuccinimide Price
- Product number
- BP-24055
- Product name
- DBCO-PEG5-NHSester
- Purity
- 96%
- Packaging
- 25mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- BP-24055
- Product name
- DBCO-PEG5-NHSester
- Purity
- 96%
- Packaging
- 100mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- BP-24055
- Product name
- DBCO-PEG5-NHSester
- Purity
- 96%
- Packaging
- 500mg
- Price
- $1650
- Updated
- 2021/12/16
DBCO-PEG5-NHS ester Chemical Properties,Usage,Production
Description
DBCO-PEG5-NHS Ester is a DBCO-containing PEG linker containing NHS ester that can react specifically and efficiently with primary amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond. PEG5 spacer increases the water solubility of compounds in aqueous media. DBCO is commonly used for copper-free Click Chemistry reaction.
Biological Activity
DBCO-PEG5-NHS ester is a PROTAC linker, belonging to the PEG class and the Alkyl/ether class, for the synthesis of a series of PROTAC molecules. DBCO-PEG5-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| Alkyl/ether
| PEGs
|
DBCO-PEG5-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
DBCO-PEG5-NHS ester Suppliers
- Tel
- 021-58088081 Q3382968513
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 3151
- Advantage
- 55
- Tel
- 0431-80514535 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 4108
- Advantage
- 55
- Tel
- 027-65563561
- Fax
- 86-27-59218822
- sales@borenpharm.com
- Country
- China
- ProdList
- 1246
- Advantage
- 55
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12308
- Advantage
- 58
- Tel
- +86-156-80926068 +86-15680926068
- 1924344760@qq.com
- Country
- China
- ProdList
- 4824
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19892
- Advantage
- 58
- Tel
- 029-86217788 13892832556
- 2440688701@qq.com
- Country
- China
- ProdList
- 1992
- Advantage
- 58
- Tel
- +86-13759708231
- asherw9@hotmail.com
- Country
- China
- ProdList
- 2351
- Advantage
- 58
- Tel
- 4000-360-990 15268198094
- sales@torreybio.com
- Country
- China
- ProdList
- 2657
- Advantage
- 58
- Tel
- 13303867194
- 3001317055@qq.com
- Country
- China
- ProdList
- 9627
- Advantage
- 58
View Lastest Price from DBCO-PEG5-NHS ester manufacturers
- Product
- DBCO-PEG5-NHS ester 2144395-59-3
- Price
- US $0.00/mg
- Min. Order
- 50mg
- Purity
- >99.00%
- Supply Ability
- 250mg
- Release date
- 2024-03-20