ChemicalBook > CAS DataBase List > Lidocaine hydrochloride

Lidocaine hydrochloride

Product Name
Lidocaine hydrochloride
CAS No.
6108-05-0
Chemical Name
Lidocaine hydrochloride
Synonyms
LINOCAINE HCL;Linocaine hydrochlor;Linocaine hydrochloride(lidocaine HCL);2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate;ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE;dolicaine;Lidocaine HC1;Lidocaine HCl USP;N-Oxide Lidocaine-d;LIDOCAINE HCL HYDRATE
CBNumber
CB4486868
Molecular Formula
C14H25ClN2O2
Formula Weight
288.82
MOL File
6108-05-0.mol
More
Less

Lidocaine hydrochloride Property

Melting point:
75-79℃
storage temp. 
2-8°C
solubility 
H2O: soluble
form 
solid
color 
white
Water Solubility 
Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
InChI
InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
InChIKey
YECIFGHRMFEPJK-UHFFFAOYSA-N
SMILES
C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl
LogP
2.359 (est)
CAS DataBase Reference
6108-05-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
AN7700000
TSCA 
Yes
HazardClass 
6.1
HS Code 
2924296000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L5647
Product name
Lidocaine hydrochloride monohydrate
Purity
solid
Packaging
15g
Price
$98.5
Updated
2024/03/01
Sigma-Aldrich
Product number
1366013
Product name
Lidocaine hydrochloride
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
150mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
BP214
Product name
Lidocaine hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$252
Updated
2023/06/20
Alfa Aesar
Product number
J63035
Product name
Lidocaine hydrochloride monohydrate, 98%
Packaging
5g
Price
$32.65
Updated
2024/03/01
Alfa Aesar
Product number
J63035
Product name
Lidocaine hydrochloride monohydrate, 98%
Packaging
25g
Price
$104
Updated
2024/03/01
More
Less

Lidocaine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.

Uses

Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Definition

ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

Application

Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

brand name

Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica); Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply).

Contact allergens

Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.

Synthesis

A method for preparing Lidocaine hydrochloride is described as follows. The method comprises the following steps: by taking 2,6-xylenol as a raw material, Pd/C as a primary catalyst and 2,6-dimethylcyclohexanone as a promoter, performing liquid phase amination with ammonia water at high temperature, thereby obtaining a midbody 2,6-dimethylaniline; enabling sodium methylate, 2,6-dimethylaniline and N,N-lignocaine methyl acetate as raw materials to react at 90-95 DEGC, distilling while reaction is performed to remove methanol till no methanol can be evaporated out, continuously reacting for 30 minutes, cooling to the room temperature, adding dichloroethane, washing with water, and leaving to stand to layer, thereby obtaining an organic layer, namely, a lidocaine based dichloroethane solution; further adding hydrochloric acid into the lidocaine based dichloroethane solution, adjusting the pH value to be 3.5-4 by using hydrogen chloride, adding activated carbon to reflux for 20-40 minutes, filtering, concentrating the filtrate, cooling, crystallizing, and dying, thereby obtaining Lidocaine hydrochloride.

Mode of action

Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

Lidocaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Lidocaine hydrochloride Suppliers

Hebei mo Jin biotechnology co., ltd
Tel
15097329902
Fax
18503279000
Email
sales@hebeimojin.com
Country
China
ProdList
1953
Advantage
58
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488 18007166089
Fax
027-81302088
Email
info@dkybpc.com
Country
China
ProdList
2024
Advantage
58
Changzhou josenchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
519-519-85286950 13338194135
Fax
0519-85286950
Email
info@josenchem.com
Country
China
ProdList
75
Advantage
58
CHANGZHOU FLUORIDE CHEMICAL CO.,LTD
Tel
0086-519-89892883 15995021858
Fax
0519-85227531
Email
info@fluoridechem.com
Country
China
ProdList
80
Advantage
58
ZEUS CHEM LTD
Tel
180-71545453 18071542427
Fax
1735832116
Email
tina@zeuschem.cn
Country
China
ProdList
354
Advantage
58
Zhejiang Synose Tech Co., Ltd.
Tel
0579-89172082 18720986928
Fax
0579-89172082
Email
191094223@qq.com
Country
China
ProdList
66
Advantage
58
xi'an renyang Biotechnology Co., Ltd.
Tel
13299086402
Email
renyangbiotech@163.com
Country
China
ProdList
80
Advantage
58
Wuhan Zenuo Biopharmaceutical Technology Co., Ltd
Tel
027-87781970 15172508891
Email
1505560767@qq.com
Country
China
ProdList
133
Advantage
58
Shandong Chenyi Environmental Protection Technology Co., Ltd
Tel
0531-83179999 13395316108
Email
cyhbkjyxgs@163.com
Country
China
ProdList
126
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
More
Less

View Lastest Price from Lidocaine hydrochloride manufacturers

Guangdong Junhua Chemical Co., Ltd
Product
Lidocaine hydrochloride 6108-05-0
Price
US $160.00-34.00/kg
Min. Order
1kg
Purity
99%pure
Supply Ability
20 tons
Release date
2024-12-11
Guangdong Junhua Chemical Co., Ltd
Product
Lidocaine hydrochloride 6108-05-0
Price
US $160.00-34.00/kg
Min. Order
1kg
Purity
99%pure
Supply Ability
20 tons
Release date
2024-12-17
Jinan Million Pharmaceutical Co., Ltd
Product
Lidocaine hydrochloride 6108-05-0
Price
US $1.00/kg
Min. Order
0.10000000kg
Purity
99%
Supply Ability
200KG
Release date
2024-07-23

6108-05-0, Lidocaine hydrochlorideRelated Search:


  • 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride
  • N1-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide hydrochloride hydrate
  • Linocaine hydrochloride(lidocaine HCL)
  • LIDOCAINE HCL BP (INJECTABLE GRADE)
  • Lignocaine monohydrate hydrochloride, Xylocaine monohydrate hydrochloride, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide monohydrate hydrochloride
  • 2-Dimethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride
  • Lidocaine Hydrochloride BP98 USP24
  • Lignocaine hydrochloride monohydrate
  • Xylocaine hydrochloride monohydrate
  • Lidocaine Hydrochloride hydrate
  • Diethylamino-2,6-dimethylacetanilide hydrochloride
  • Lidocaine hydrochloride monohydrate,2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
  • Linocaine hydrochlor
  • 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate
  • Linocaine hydrochloride hydrate
  • Linocaine hydrochloride monohydrate
  • Lidocaine HCl USP
  • LidocaineHclLidocaineHclBp
  • 2-diethylamino-n-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate
  • LIDOCAINEHYDROCHLORIDE,MONOHYDRATE,USP
  • lidocainemonohydratehydrochloride
  • 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
  • LINOCAINE HCL
  • LIDOCAINE HYDROCHLORIDE DAB, PH.EUR.
  • Lidocine hydrochloride pure
  • acetamide hydrochloride hydrate
  • -N-(2,6-dimethylphenyl)
  • 2-(DIETHYLAMINO)-N- (2,6-DIMETHYLPHENY ) ACETAMIDE HYDROCHLORIDE ( LIDOCAINE HCL )
  • ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE
  • LINOCAINE HYDROCHLORIDE
  • LIDOCAINE HCL HYDRATE
  • LIDOCAINE HYDROCHLORIDE, MONOHYDRATE
  • 2’,6’-acetoxylidide,2-(diethylamino)-,hydrochloride,hydrate
  • acetamide,2-(diethylamino)-n-(2,6-dimethylphenyl)-,monohydrochloride,monoh
  • diethylaminoacet-2,6-xylididehydrochloridemonohydrate
  • dolicaine
  • N-(2,6-dimethylphenyl)-N2,N2-diethylglycinamide perfluorooctanesulfonic acid
  • Linocaine hydrochloride USP/EP/BP
  • LIDOCAINE HYDROCHLORIDE,0.99
  • Lidocaine hydrochloride impurity890
  • Lidocaine Hydrochloride (1366013)
  • Lidocaine HC1
  • Lidocaine Hydrochloride (150 mg)
  • N-Oxide Lidocaine-d
  • LIDOCAINE HYDROCHLORIDE
  • C14629800 LidocainEhydrochloridEmonohydrate
  • Linocaine hydrochlorideEdit
  • 6108-05-0
  • 6108-5-0
  • C12H18N2OHClH2O
  • C14H22N2OHClH2O
  • C14H25ClN2O2
  • Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Voltage-gated Ion Channels
  • Sodium Channel Modulators