Linocaine hydrochloride
- Product Name
- Linocaine hydrochloride
- CAS No.
- 6108-05-0
- Chemical Name
- Linocaine hydrochloride
- Synonyms
- LINOCAINE HCL;Linocaine hydrochlor;Linocaine hydrochloride(lidocaine HCL);2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate;ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE;dolicaine;Lidocaine HC1;Lidocaine HCl USP;LIDOCAINE HCL HYDRATE;-N-(2,6-dimethylphenyl)
- CBNumber
- CB4486868
- Molecular Formula
- C14H25ClN2O2
- Formula Weight
- 288.82
- MOL File
- 6108-05-0.mol
Linocaine hydrochloride Property
- Melting point:
- 75-79℃
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- solid
- color
- white
- Water Solubility
- Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
- InChI
- InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
- InChIKey
- YECIFGHRMFEPJK-UHFFFAOYSA-N
- SMILES
- C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl
- LogP
- 2.359 (est)
- CAS DataBase Reference
- 6108-05-0(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- L5647
- Product name
- Lidocaine hydrochloride monohydrate
- Purity
- solid
- Packaging
- 15g
- Price
- $98.5
- Updated
- 2024/03/01
- Product number
- 1366013
- Product name
- Lidocaine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 150mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- BP214
- Product name
- Lidocaine hydrochloride
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 100MG
- Price
- $252
- Updated
- 2023/06/20
- Product number
- J63035
- Product name
- Lidocaine hydrochloride monohydrate, 98%
- Packaging
- 5g
- Price
- $32.65
- Updated
- 2024/03/01
- Product number
- J63035
- Product name
- Lidocaine hydrochloride monohydrate, 98%
- Packaging
- 25g
- Price
- $104
- Updated
- 2024/03/01
Linocaine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.
Uses
Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Definition
ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.
Application
Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.
brand name
Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica); Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply).
Contact allergens
Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.
Mode of action
Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.
Linocaine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Linocaine hydrochloride manufacturers
- Product
- Linocaine hydrochloride hydrate 6108-05-0
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2024-03-11
- Product
- Linocaine hydrochloride 6108-05-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2023-07-14
- Product
- Lidocaine hydrochloride 6108-05-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2023-09-05