ChemicalBook > CAS DataBase List > WYC-209
WYC-209
- Product Name
- WYC-209
- CAS No.
- 2131803-90-0
- Chemical Name
- WYC-209
- Synonyms
- WYC-209;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate , WYC-209;Apoptosis,WYC-209,WYC 209,Retinoid X receptors,Inhibitor,Retinoic acid receptors,Autophagy,RAR/RXR,inhibit;5-Pyrimidinecarboxylic acid, 2-[2-(3,4-dihydro-4,4-dimethyl-1-oxido-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester
- CBNumber
- CB44888914
- Molecular Formula
- C20H20N2O3S
- Formula Weight
- 368.45
- MOL File
- 2131803-90-0.mol
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WYC-209 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 83.33 mg/mL (226.16 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML2402
- Product name
- WYC-209
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $95
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML2402
- Product name
- WYC-209
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $227.5
- Updated
- 2025/07/31
ChemScene
- Product number
- CS-0084453
- Product name
- WYC-209
- Purity
- 99.64%
- Packaging
- 5mg
- Price
- $450
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- BRS0009231
- Product name
- WYC-209
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $455.27
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0084453
- Product name
- WYC-209
- Purity
- 99.64%
- Packaging
- 10mg
- Price
- $750
- Updated
- 2021/12/16
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WYC-209 Chemical Properties,Usage,Production
Uses
WYC-209 RAR Agonist is used in the preparation of the retinoid compounds and their application as anticancer agents.
Biological Activity
Synthetic retinoid with antiproliferative activity', 'WYC-209 is a synthetic retinoid with antiproliferative activity and better inhibition of cancer cell growth and proliferation than Tazarotene or ATRA (all-trans-retinoic acid). WYC-209 was shown to inhibit proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with an IC50 value of 190 nM and also inhibited proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.
in vivo
WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases[1].
| Animal Model: | Female immune-competent C57BL/6 mice[1] |
| Dosage: | 0.022, 0.22?mg/kg |
| Administration: | Intravenous injection; once every two days for 25 days |
| Result: | Four out of eight mice formed lung metastases at dose of 0.022?mg?/kg, only one out of eight mice formed lung metastases at dose of 0.22?mg/kg. |
WYC-209 Preparation Products And Raw materials
Raw materials
Preparation Products
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WYC-209 Suppliers
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- Fax
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- China
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