ChemicalBook > CAS DataBase List > WYC-209

WYC-209

Product Name
WYC-209
CAS No.
2131803-90-0
Chemical Name
WYC-209
Synonyms
WYC-209;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate , WYC-209;Apoptosis,WYC-209,WYC 209,Retinoid X receptors,Inhibitor,Retinoic acid receptors,Autophagy,RAR/RXR,inhibit;5-Pyrimidinecarboxylic acid, 2-[2-(3,4-dihydro-4,4-dimethyl-1-oxido-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester
CBNumber
CB44888914
Molecular Formula
C20H20N2O3S
Formula Weight
368.45
MOL File
2131803-90-0.mol
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WYC-209 Property

storage temp. 
Store at -20°C
solubility 
DMSO : 83.33 mg/mL (226.16 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2402
Product name
WYC-209
Purity
≥98% (HPLC)
Packaging
5MG
Price
$95
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2402
Product name
WYC-209
Purity
≥98% (HPLC)
Packaging
25MG
Price
$227.5
Updated
2025/07/31
ChemScene
Product number
CS-0084453
Product name
WYC-209
Purity
99.64%
Packaging
5mg
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0009231
Product name
WYC-209
Purity
95.00%
Packaging
5MG
Price
$455.27
Updated
2021/12/16
ChemScene
Product number
CS-0084453
Product name
WYC-209
Purity
99.64%
Packaging
10mg
Price
$750
Updated
2021/12/16
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WYC-209 Chemical Properties,Usage,Production

Uses

WYC-209 RAR Agonist is used in the preparation of the retinoid compounds and their application as anticancer agents.

Biological Activity

Synthetic retinoid with antiproliferative activity', 'WYC-209 is a synthetic retinoid with antiproliferative activity and better inhibition of cancer cell growth and proliferation than Tazarotene or ATRA (all-trans-retinoic acid). WYC-209 was shown to inhibit proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with an IC50 value of 190 nM and also inhibited proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.

in vivo

WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases[1].

Animal Model:Female immune-competent C57BL/6 mice[1]
Dosage:0.022, 0.22?mg/kg
Administration:Intravenous injection; once every two days for 25 days
Result:Four out of eight mice formed lung metastases at dose of 0.022?mg?/kg, only one out of eight mice formed lung metastases at dose of 0.22?mg/kg.

WYC-209 Preparation Products And Raw materials

Raw materials

Preparation Products

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WYC-209 Suppliers

China 34 United States 4 Global 38
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58

2131803-90-0, WYC-209Related Search:

WYC-210

  • WYC-209
  • 5-Pyrimidinecarboxylic acid, 2-[2-(3,4-dihydro-4,4-dimethyl-1-oxido-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester
  • Apoptosis,WYC-209,WYC 209,Retinoid X receptors,Inhibitor,Retinoic acid receptors,Autophagy,RAR/RXR,inhibit
  • Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate
  • Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate , WYC-209
  • 2131803-90-0