IAXO-102
- Product Name
- IAXO-102
- CAS No.
- 1115270-63-7
- Chemical Name
- IAXO-102
- Synonyms
- IAXO-102;IAXO-102 (CD14/TLR4 Antagonist) (synthetic);Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside;α-D-Glucopyranoside, methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-;IAXO102,IAXO 102,Toll-like Receptor (TLR),Inhibitor,IAXO-102,inhibit
- CBNumber
- CB44927534
- Molecular Formula
- C35H71NO5
- Formula Weight
- 585.96
- MOL File
- 1115270-63-7.mol
IAXO-102 Property
- Boiling point:
- 650.2±55.0 °C(Predicted)
- Density
- 0.96±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Ethanol : 50 mg/mL (85.33 mM; Need ultrasonic)|DMSO : 5 mg/mL (8.53 mM; Need ultrasonic)
- form
- A solid
- pka
- 13.00±0.70(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- IAX-600-002-M001
- Product name
- IAXO-102(CD14/TLR4Antagonist)(synthetic)
- Purity
- ≥98%(TLC)
- Packaging
- 1mg
- Price
- $223
- Updated
- 2021/12/16
- Product number
- CS-0089755
- Product name
- IAXO-102
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0089755
- Product name
- IAXO-102
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0089755
- Product name
- IAXO-102
- Purity
- >98.0%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0089755
- Product name
- IAXO-102
- Purity
- >98.0%
- Packaging
- 100mg
- Price
- $2650
- Updated
- 2021/12/16
IAXO-102 Chemical Properties,Usage,Production
Biological Activity
IAXO-102 is a TLR4 antagonist targeting the MD-2 and CD14 co-receptors,which inhibits MAPK and p65 NF-κB phosphorylation and downregulates the expression of TLR4-dependent pro-inflammatory proteins. It inhibits the development of experimental abdominal aortic aneurysm (AAA).
in vitro
IAXO-102 (1-10 μM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells.
IAXO-102 (10 μM, for 17 hours) suppresses LPS induced proinflammatory proteins MCP-1 and IL-8 production in HUVEC.
Western Blot Analysis
| Cell Line: | Human umbilical vein endothelial (HUVEC) cells |
| Concentration: | 1-10 μM |
| Incubation Time: | Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour |
| Result: | Significantly inhibited LPS- stimulated MAPK/p65nF-ΚB phosphorylation. |
in vivo
IAXO-102 (3 mg/kg/day, sc for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice.
| Animal Model: < /td> | Six-monthold ApoE ?/? /C57Bl6 |
| Dosage: | 3 mg/kg/day |
| Administration: | SC for 28 days |
| Result: | Significantly retarded Angiotensin II -induced increase in aortic diameter. |
target
| Target | Value |
| TLR4 () | |
| MAPK () | |
| NF-κB () |
IAXO-102 Preparation Products And Raw materials
Raw materials
Preparation Products
IAXO-102 Suppliers
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