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MERBARONE

Product Name
MERBARONE
CAS No.
97534-21-9
Chemical Name
MERBARONE
Synonyms
RLBN1001;RLBN-1001;MERBARONE;NSC-336628;Merbarone - CAS 97534-21-9 - Calbiochem;5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID;5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID;5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628;hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid;4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
CBNumber
CB4494665
Molecular Formula
C11H9N3O3S
Formula Weight
263.27
MOL File
97534-21-9.mol
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MERBARONE Property

Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >5mg/mL
form 
solid
pka
-2.16±0.20(Predicted)
color 
Pink to purple
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Safety

WGK Germany 
3
RTECS 
UV7714625
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M2070
Product name
Merbarone
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$166
Updated
2025/07/31
Sigma-Aldrich
Product number
445800
Product name
Merbarone
Packaging
25mg
Price
$148
Updated
2025/07/31
Usbiological
Product number
454363
Product name
Merbarone
Packaging
25mg
Price
$375
Updated
2021/12/16
TRC
Product number
M800603
Product name
Merbarone
Packaging
25mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0014735
Product name
Merbarone
Purity
≥99.0%
Packaging
5mg
Price
$90
Updated
2021/12/16
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MERBARONE Chemical Properties,Usage,Production

Uses

Merbarone has been used to study its effect on the occurrence of DNA lesions.

General Description

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC50 = 20 μM for purified mammalian topo II versus IC50 = ~ 200 μM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

Biochem/physiol Actions

Cell permeable: yes

in vivo

Merbarone (50 mg/kg; daily i.p. for 5 d) achieves a maximum increased life span (ILS) of 101% in P388 murine leukemia[2].
Merbarone (124 mg/kg; daily p.o. for 9 d) has anti-tumor activity in mice[2].

MERBARONE Preparation Products And Raw materials

Raw materials

Preparation Products

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MERBARONE Suppliers

China 31 Switzerland 1 United Kingdom 4 United States 9 Global 45
Sigma-Aldrich
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021-61415566 800-8193336
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Chunchuang (Wuhan) Technology Co., Ltd
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Bide Pharmatech Ltd.
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400-1647117 13681763483
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TargetMol Chemicals Inc.
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marketing@tsbiochem.com
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Shanghai Tachizaki Biomedical Research Center
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sales@chemlab-tachizaki.com
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Suzhou Haiben Pharmaceutical Co., Ltd
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RD International Technology Co., Limited
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028-81700200 13308200041
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Merck Millipore
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Merck KGaA
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Selleck Chemicals
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Santa Cruz Biotechnology Inc
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Dongguan Biaobiao Experimental Equipment Technology Co., Ltd.
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97534-21-9, MERBARONERelated Search:

MERBARONE

  • 4,6-dioxo-N-phenyl-2-sulfanylidene-1,3-diazinane-5-carboxamide
  • Merbarone - CAS 97534-21-9 - Calbiochem
  • 5-(N-PHENYLCARBAMOYL)-2-THIOBARBITURIC ACID
  • 5-(N-PHENYLCARBOXAMIDO)-2-THIOBARBITURIC ACID
  • NSC-336628
  • hexahydro-4,6-dioxo-n-phenyl-2-thioxo-5-pyrimidinecarboxamid
  • 5-(N-Phenylcarbamoyl)-2-thiobarbituric acid, NSC-336628
  • MERBARONE
  • 5-Pyrimidinecarboxamide, hexahydro-4,6-dioxo-N-phenyl-2-thioxo-
  • RLBN1001
  • RLBN-1001
  • 4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide , Merbarone
  • 4,6-Dioxo-N-phenyl-2-thioxohexahydropyrimidine-5-carboxamide
  • 97534-21-9
  • Reagents
  • Tools for Gene Regulation Research
  • Gene Regulation and Expression
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical