A-317491 DISODIUM SALT

Product Name: A-317491 DISODIUM SALT
CAS No.: 475205-49-3
Chemical Name: A-317491 DISODIUM SALT
Synonyms: ABT 202;A-317491 sodium;A-317491 ，S8519;A 317491;A317491;4-tricarboxylic acid;A-317491 DISODIUM SALT;A-317491, 10 mM in DMSO;A-317491;A 317491;A317491;(S)-5-((3-phenoxybenzyl)(1;4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1
CBNumber: CB4497848
Molecular Formula: C33H27NO8
Formula Weight: 565.57
MOL File: 475205-49-3.mol

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A-317491 DISODIUM SALT Property

Boiling point:: 840.4±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: H₂O: ~34 mg/mL
pka: 2.57±0.10(Predicted)
form: powder
color: white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19256
Product name: A-317491
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 19256
Product name: A-317491
Purity: ≥98%
Packaging: 5mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 19256
Product name: A-317491
Purity: ≥98%
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 19256
Product name: A-317491
Purity: ≥98%
Packaging: 25mg
Price: $299
Updated: 2024/03/01

TRC

Product number: A965315
Product name: A-317491
Packaging: 5mg
Price: $130
Updated: 2021/12/16

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A-317491 DISODIUM SALT Chemical Properties,Usage,Production

Uses

A-317491 is a P2X3 and P2X2/3 receptor antagonist.

in vivo

A-317491 (0.1-30 mg/kg; a single s.c.) dose-dependently reverses inflammatory mechanical hyperalgesia in rats^[2].
A-317491 (3-30 mg/kg; a single .v.) exhibits the plasma half-life (7.38 h), clearance rate (1.83 L/h/kg), and volume of distribution (0.17 L/kg)^[2].

Animal Model:	Male adult Sprague-Dawley rats received an intraplantar injection of Freund's complete adjuvant^[2]
Dosage:	0.1, 1, 3, 10, 30 mg/kg
Administration:	A single s.c.
Result:	Produced a dose-dependent reduction in mechanical hyperalgesia 1 h, 3 h and 5 h post-administration.

IC 50

P2X3 Receptor

A-317491 DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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A-317491 DISODIUM SALT Suppliers

China 53 India 1 Switzerland 1 United States 9 Global 64

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475205-49-3, A-317491 DISODIUM SALTRelated Search:

(S)-5-((3-phenoxybenzyl)(1

4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1

4-tricarboxylic acid

A 317491;A317491;(S)-5-((3-PHENOXYBENZYL)(1;2;3;4-TETRAHYDRONAPHTHALEN-1-YL)CARBAMOYL)BENZENE-1;2;4-TRICARBOXYLIC ACID; SODIUM SALT HYDRATE

A-317491 DISODIUM SALT

(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbaMoyl)benzene-1,2,4-tricarboxylic acid

5-[[(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid

A-317491 sodium

A-317491;A 317491;A317491

A 317491;A317491

ABT 202

1,2,4-Benzenetricarboxylic acid, 5-[[[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-

flux,calcium,P2X Receptor,A 317491,Inhibitor,neuropathic,inhibit,P2X2/3,A317491,P2X3,P2XRs,pain,A-317491,inflammatory

A-317491, 10 mM in DMSO

A-317491 ，S8519

475205-49-3